Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ETV1 (P50549) - Overview - Molecular Target Synopsis

Protein


ETV1, ETS translocation variant 1
UniProt P50549

Also Known as ETV1_HUMAN, ETV1, ER81

Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.

5ILS
AUTOINHIBITED ETV1
RCSB/PDB
Inspect Structure
See all 3D Structures for ETV1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ETV1 is active in the following subcellular-locations: nucleus.
GO terms: ETV1 is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ETV1 has gain in 16 cell-lines, loss in 3 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H460, M14, SF_295

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SW 900, HCC12, MKN-45

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: hMSC-AT, SK-N-SH_RA, SK-N-SH

(see details)

3D Structures


For ETV1 there are:
3 structures (6 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ETV1 has been screened with 1 compounds (1 bioactivities). (see details)