Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SERPINH1 (P50454) - Overview - Molecular Target Synopsis

Protein


SERPINH1, Serpin H1
UniProt P50454

Also Known as SERPH_HUMAN, SERPINH1, CBP1, CBP2, HSP47, SERPINH2

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SERPINH1 is active in the following subcellular-locations: endoplasmic reticulum lumen.
GO terms: SERPINH1 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum-Golgi intermediate compartment, extracellular exosome, membrane raft.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SERPINH1 has gain in 7 cell-lines, loss in 0 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, SNB_75, SF_539

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G59, G96, Hs 578T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: IMR-90, BJ, SK-N-SH

(see details)

RNA Interference


SERPINH1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


At greater than 90% identity similarity to SERPINH1 there are:
4 structures (23 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SERPINH1 has been screened with 4 compounds (4 bioactivities). (see details)