Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HNMT (P50135) - Overview - Molecular Target Synopsis

Protein


HNMT, Histamine N-methyltransferase
Enzyme Classification 2.1.1.8
UniProt P50135

Also Known as HNMT_HUMAN, HNMT

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. Monomer.

2AOU
HISTAMINE METHYLTRANSFERASE COMPLEXED WITH THE ANTIMALARIAL DRUG AMODIAQUINE
RCSB/PDB
Inspect Structure
See all 3D Structures for HNMT

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: HNMT is active in the following subcellular-locations: cytoplasm.
GO terms: HNMT is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome, neuron projection.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HNMT has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: U251, SK_MEL_2, HOP_92

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hep G2, NCI-H727, C3A

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, HSMM

(see details)

3D Structures


For HNMT there are:
7 structures (14 chains) solved
7 are solved in complex with at least one small molecule ligand
5 are solved with an approved drug

HNMT is solved in complex with the approved drug(s):

2PM/DIPHENHYDRAMINE (2AOT_A, 2AOT_B),
HSM/HISTAMINE (1JQD_A, 1JQD_B),
THA/TACRINE (2AOW_A, 2AOW_B, 2AOX_A, 2AOX_B),
CQA/AMODIAQUINE (2AOU_A, 2AOU_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HNMT has been screened with 9 compounds (13 bioactivities), 4 compounds have bioactivities that show binding affinity of <= 500nM (5 bioactivities). (see details)