Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RBP2 (P50120) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed88
Chains with at least one site assessed as druggable using the strict criteria60
Chains with at least one site assessed as druggable using the relaxed criteria88


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5DG4_D Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 89.7 18.2 Yes Yes
2 empty 2.46 64.7 18.1 No No
3 empty 2.39 67.2 12.3 No No
4 empty 2.27 63.3 12.5 No No
5 empty 2.46 65.7 12.1 No No
6 empty 2.66 61.3 13.3 No No
7 empty 2.13 61.4 7.5 No No
8 empty 2.34 69.8 6.6 No No
9 empty 2.54 56.9 7.8 No No
10 empty 2.15 71.7 7.1 No No
5FAZ_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 87.5 24.3 Yes Yes
2 empty 2.32 69.4 16.6 No No
3 empty 1.96 65.5 12.4 No No
4 empty 2.01 62.4 12.9 No No
5 empty 1.94 59 11.8 No No
6 empty 2.47 71.3 11.2 No No
7 empty 2.95 71.4 7.1 No No
8 empty 2.43 62.1 7.9 No No
9 empty 2.38 63.6 8.5 No No
10 empty 1.93 70.7 6.5 No No
4ZGU_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 68.5 17.5 No No
2 bound 1.66 95.3 0 Yes Yes
3 empty 2.36 59.7 12.3 No No
4 empty 1.88 68.4 11.6 No No
5 empty 2.14 64.8 10.2 No No
6 empty 2.8 65.8 6.3 No No
7 bound 1.2 96.5 0 Yes No
8 empty 2.26 63.6 8 No No
9 empty 2.44 59.2 12.1 No No
10 empty 2.62 65.5 11.6 No No
4QYP_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.45 98.6 0 Yes Yes
2 empty 2.27 67.9 11.4 No No
3 empty 2.38 64.9 13.2 No No
4 empty 2.11 65.2 8.7 No No
5 empty 2.41 69.5 9.4 No No
6 empty 2.19 60.5 9.8 No No
7 empty 2.02 69.2 7 No No
8 empty 2.1 63.4 8.9 No No
9 empty 2.53 63.7 8.6 No No
10 empty 2.67 63.4 6 No No
4ZJ0_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 86.3 24.7 Yes Yes
2 empty 2.48 68.8 18.5 No No
3 empty 2.21 64.6 11.8 No No
4 empty 2.52 62.3 14.6 No No
5 empty 2.4 64.1 10.9 No No
6 empty 2.11 67 8.9 No No
7 empty 2.38 63.4 10.9 No No
8 empty 2.08 72.8 6 No No
9 empty 2.68 65.5 7 No No
10 empty 2.35 66.7 8.2 No No
4EXZ_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.5 99 0 Yes Yes
2 empty 2.13 65.6 14.2 No No
3 empty 2.31 67.6 9.4 No No
4 empty 2.54 61.9 14.8 No No
5 empty 1.77 59.8 10.7 No No
6 empty 2.63 61.9 15.5 No No
7 empty 2.16 68.1 9.7 No No
8 empty 2.08 67.6 6.8 No No
9 empty 2.73 72.9 8.9 No No
10 empty 2.32 56.7 12.8 No No
6E5S_C Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 61.7 28.3 Yes No
2 empty 2.18 56.9 26.7 No No
3 empty 2.68 61.8 21.1 No No
4 empty 2.37 62.3 17.1 No No
5 empty 1.81 58.8 21 No No
6 empty 2.2 71.1 12.3 No No
7 empty 3.07 57.8 15.4 No No
8 empty 1.78 59.4 13.2 No No
9 empty 2.51 64.8 9.8 No No
10 empty 1.11 19.4 9.1 No No
5F58_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 85 25.2 Yes Yes
2 empty 2.26 66.7 16.8 No No
3 empty 2.09 62.8 14.8 No No
4 empty 1.59 64.2 9.6 No No
5 empty 2.34 62.8 8.5 No No
6 empty 2.27 59.1 11.3 No No
7 bound 2.44 61.7 8.9 No No
8 empty 2.59 69.1 9.6 No No
9 empty 2.94 70 11.2 No No
10 empty 1.88 69.7 6.1 No No
4QYN_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 98.6 0 Yes Yes
2 empty 2.31 68.7 13.5 No No
3 empty 2.21 60 16.3 No No
4 empty 2.46 66.4 12.1 No No
5 empty 2.36 64 10.3 No No
6 empty 1.99 73.7 6.5 No No
7 empty 2.43 59.7 9 No No
8 empty 1.72 52.2 8.3 No No
9 empty 2.55 75.3 6.8 No No
10 empty 2.7 61.5 7.9 No No
5DPQ_B Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 59.2 43.7 Yes No
2 empty 1.93 57.9 26.2 No No
3 empty 1.97 62.9 21.8 No No
4 empty 2.15 65.4 19 No No
5 empty 2.07 66.2 12.1 No No
6 empty 3.28 67.1 6.1 No No
7 empty 2.36 62.2 10.1 No No
8 empty 2.24 62.6 8.3 No No
9 empty 3.24 56.7 10.6 No No
10 empty 2.57 63.1 7.4 No No
5F6B_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 82 22.8 Yes Yes
2 empty 2.44 68.3 17.8 No No
3 empty 2.51 65.6 17 No No
4 empty 2.32 63.4 13.8 No No
5 empty 2.7 60.5 15.8 No No
6 empty 2.22 76.7 6.6 No No
7 empty 1.86 68.5 8.6 No No
8 empty 2.19 60.2 7.6 No No
9 empty 2.5 57.9 7.1 No No
10 bound 1.46 100 0 Yes No
4ZGU_C Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 81.7 19.8 Yes Yes
2 empty 2.44 64.8 16.7 No No
3 empty 2.57 66.1 10.6 No No
4 empty 2.55 67.5 11.5 No No
5 empty 2.31 56.7 14.4 No No
6 empty 2.31 67.8 9.6 No No
7 empty 2.24 62.4 8.4 No No
8 empty 2.41 67.1 6.6 No No
9 empty 3 55.8 9.1 No No
10 empty 2.75 50.8 7 No No
4EDE_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 93.6 19.9 Yes Yes
2 empty 2.39 66.9 18.9 No No
3 empty 1.86 65.9 10.6 No No
4 empty 2.39 66.7 18.2 No No
5 empty 2.36 67.2 10.7 No No
6 empty 2.58 63.2 14.7 No No
7 empty 2.94 64.7 6.8 No No
8 empty 2.1 66.1 7.3 No No
9 empty 2.58 61.2 7 No No
10 empty 2.57 54.7 7.1 No No
6E5S_E Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 63.7 30 Yes No
2 empty 1.77 57.9 27.1 No No
3 empty 2.16 60.1 20.4 No No
4 empty 2.23 68.5 14.5 No No
5 empty 2.36 60.1 16.4 No No
6 empty 2.48 50.9 13.4 No No
7 empty 2.28 60.7 15.7 No No
8 empty 3.07 60.3 15.1 No No
9 empty 1.79 29.7 13.7 No No
10 empty 2.51 69.1 8.4 No No
6E5S_H Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 62.5 31.6 Yes No
2 empty 2.64 54.9 31.4 No No
3 empty 2.17 57.1 26.4 No No
4 empty 2.09 55.5 20.7 No No
5 empty 2.26 69.6 11.3 No No
6 empty 2.16 70.4 8.6 No No
7 empty 2.82 59.8 11.2 No No
8 empty 2.84 75 8.5 No No
9 empty 1.4 64.4 6.7 No No
10 empty 2.62 60.8 8.9 No No
5FEN_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.3 98.7 0 Yes Yes
2 empty 2.19 64.5 16.7 No No
3 empty 1.99 62.3 16.8 No No
4 empty 2.49 62.1 12.7 No No
5 empty 2.15 68.1 11.5 No No
6 empty 2.5 72.1 8.5 No No
7 empty 2.34 69.4 9.9 No No
8 empty 2.4 69.6 6.6 No No
9 empty 1.99 73.4 5.8 No No
10 empty 2.25 60.6 8 No No
5FFH_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 88.9 22.1 Yes Yes
2 empty 2.52 66 19 No No
3 empty 2.11 63 15.1 No No
4 empty 1.98 69 10.4 No No
5 empty 2.51 69.4 8.2 No No
6 empty 2.58 61 11.3 No No
7 empty 2.27 68.9 6.9 No No
8 empty 2.58 63.2 8.5 No No
9 empty 2.39 63.6 5.8 No No
10 empty 1.95 66.3 8.8 No No
4QZU_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 98.3 0 Yes Yes
2 empty 2.41 61.6 23.3 No No
3 empty 1.78 60.9 13.1 No No
4 empty 2.53 65.3 12.4 No No
5 empty 2.95 61.6 12.8 No No
6 empty 2.31 67.4 11.6 No No
7 empty 2.55 64.3 7.7 No No
8 empty 2.53 64.2 8.6 No No
9 empty 2.29 63.7 9.4 No No
10 empty 2.06 62.3 7.8 No No
6E5S_D Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.57 63.4 28.6 Yes No
2 empty 1.74 55.5 26.3 No No
3 empty 2.48 53.6 25.3 No No
4 empty 2.46 65.6 20.4 No No
5 empty 2 54.7 19.1 No No
6 empty 2.16 65.9 11.9 No No
7 empty 2.3 63.4 12.8 No No
8 empty 3.2 60.5 15.3 No No
9 empty 2 60.8 11.8 No No
10 empty 2.37 55.5 12.5 No No
6E5S_J Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 62.3 28.6 Yes No
2 empty 2.21 55.7 27 No No
3 empty 1.99 58.9 25.6 No No
4 empty 2.44 65.9 16 No No
5 empty 2.58 60 17.8 No No
6 empty 2.58 67.4 10.7 No No
7 empty 1.4 35.4 12 No No
8 empty 2.07 59.4 13.2 No No
9 empty 2.96 61.4 10.9 No No
10 empty 2.2 68.1 9.1 No No
5U6G_H Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 64.8 30.3 Yes No
2 empty 2.53 57.9 22 No No
3 empty 1.92 52.9 25.8 No No
4 empty 2.43 64.7 14.5 No No
5 empty 1.57 57.7 15.4 No No
6 empty 2.28 65.6 11 No No
7 empty 3.11 64.2 13.9 No No
8 empty 2.05 65 9.6 No No
9 empty 1.68 74.8 8.8 No No
10 empty 2.42 56 10 No No
4QZT_D Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.51 98.3 0 Yes Yes
2 empty 2.24 69.6 16.1 No No
3 empty 2.41 65.4 13.6 No No
4 empty 2.29 66.2 11.3 No No
5 empty 2.19 61.3 13.8 No No
6 empty 1.83 66.7 9.3 No No
7 empty 2.28 63.2 6.6 No No
8 empty 1.64 54.5 10.2 No No
9 empty 2.16 73.6 5.6 No No
10 empty 2.86 59.9 8.6 No No
5U6G_F Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 64.3 30.7 Yes No
2 empty 1.95 55.8 26.3 No No
3 empty 2.36 58.1 24.2 No No
4 empty 1.9 65.2 13.8 No No
5 empty 1.96 55.6 16.1 No No
6 empty 2.57 63.5 8.9 No No
7 empty 1.94 61.2 16.7 No No
8 empty 1.67 38.8 11 No No
9 empty 2.94 58.2 10.7 No No
10 empty 1.83 60.7 12.1 No No
6E5S_F Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 65.2 29.9 Yes No
2 empty 1.94 55.8 26.7 No No
3 empty 2.39 53.4 27.2 No No
4 empty 1.9 58.4 19.8 No No
5 empty 2.25 69.5 14.7 No No
6 empty 2.32 69.9 9.7 No No
7 empty 2.11 69.6 9.9 No No
8 empty 2.96 59.2 15.5 No No
9 empty 1.83 59.2 14.4 No No
10 empty 2.46 66.2 9.7 No No
5U6G_K Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 62.5 28.3 Yes No
2 empty 2.23 55.1 27.7 No No
3 empty 2.59 56.7 19.2 No No
4 empty 2.15 64.6 16.9 No No
5 empty 1.72 39.1 14.4 No No
6 empty 1.96 58.5 15.7 No No
7 empty 2.24 70.1 11.9 No No
8 empty 2.18 54 9.5 No No
9 empty 2.92 56.9 11 No No
10 empty 2.42 75.3 8.3 No No
4ZR2_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 67.9 31.5 Yes Yes
2 empty 2.29 64.1 28.1 No No
3 empty 2.01 56.2 26.2 No No
4 empty 2.22 67.6 18.3 No No
5 empty 1.81 57 19.7 No No
6 bound 2.1 64.9 16.2 No No
7 empty 2.27 63.7 8.2 No No
8 empty 3.2 60.5 10.6 No No
9 empty 3.09 59.6 11.7 No No
10 empty 3.43 72.1 8.8 No No
5U6G_D Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 63.2 29.4 Yes No
2 empty 2.23 56.3 27.1 No No
3 empty 2.09 63.7 16.4 No No
4 empty 2.73 57.8 18.1 No No
5 empty 2.47 53.1 17.4 No No
6 empty 1.84 47.9 17.6 No No
7 empty 2.53 65.3 14.3 No No
8 empty 1.69 33.4 13.6 No No
9 empty 1.72 59 8.3 No No
10 empty 1.06 71 8.7 No No
4QYP_C Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 98.1 0 Yes Yes
2 empty 1.79 63.4 10.5 No No
3 empty 2.39 68.1 17.5 No No
4 empty 2.54 68.3 9.8 No No
5 empty 2.44 69.2 11.7 No No
6 empty 2.43 55.1 14.3 No No
7 empty 2.3 71.1 7.2 No No
8 empty 2.21 59.5 9.2 No No
9 empty 2.81 63 5.6 No No
10 empty 2.16 71.3 6.1 No No
4QZU_D Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.67 98 0 Yes Yes
2 empty 2.12 67.8 16.9 No No
3 empty 2.11 69.1 10.8 No No
4 empty 2.14 61.1 12.1 No No
5 empty 2.4 63.6 13.1 No No
6 empty 2.75 64.2 8.9 No No
7 empty 2.22 68.8 8 No No
8 bound 2.45 71.7 0 No No
9 empty 2.51 68.7 10.1 No No
10 empty 2.73 57.6 9.9 No No
2RCQ_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.55 97.7 0 Yes Yes
2 empty 2.33 57.2 18.2 No No
3 empty 2.23 63.1 13.2 No No
4 empty 2.33 52 13.6 No No
5 empty 2 67 11.2 No No
6 bound 2.58 68 9.9 No No
7 empty 2.48 69.3 10.4 No No
8 empty 2.08 52.7 11 No No
9 bound 2.69 64.6 8.6 No No
10 empty 1.8 66.5 7.9 No No
4EEJ_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.14 97.7 0 Yes Yes
2 empty 2.16 66.8 18.3 No No
3 empty 2.17 64.5 16.8 No No
4 empty 1.8 66 9.2 No No
5 empty 2.16 63.8 13.1 No No
6 empty 2.32 69.9 9.7 No No
7 empty 1.89 73.8 7 No No
8 empty 2.39 68.4 11.3 No No
9 empty 2.52 62.7 8.6 No No
10 empty 2.4 57.5 12.4 No No
6E5S_K Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 60.7 35.1 Yes No
2 empty 2.11 58.5 27.4 No No
3 empty 2.39 60.3 19.4 No No
4 empty 2.34 62.2 13.3 No No
5 empty 1.75 50.9 12.2 No No
6 empty 2.18 65.5 12.3 No No
7 empty 2.21 74.4 6.7 No No
8 empty 2.18 53.6 11.3 No No
9 empty 3.07 57.8 15.2 No No
10 empty 2.15 68.5 7.8 No No
4ZH6_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 66.4 31.6 Yes Yes
2 empty 2.13 58.7 17.3 No No
3 empty 1.95 58 25.3 No No
4 empty 2.46 57.7 23.6 No No
5 empty 2.06 62.3 19.8 No No
6 empty 2.22 65.7 14.6 No No
7 empty 1.62 26.2 10.2 No No
8 empty 1.83 64.6 5.7 No No
9 empty 1.69 77.6 6 No No
10 empty 3.35 75.8 3.4 No No
5DG4_C Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 85.1 21.2 Yes Yes
2 empty 2.32 67.8 19.3 No No
3 empty 2.39 63.4 19.5 No No
4 empty 2.81 62.5 13.4 No No
5 empty 2.18 60.7 8.8 No No
6 empty 1.97 69.4 8.1 No No
7 empty 2.05 71 6.5 No No
8 empty 2.52 58.9 8.7 No No
9 empty 2.72 63.2 12.1 No No
10 empty 2.38 68.1 5.3 No No
5U6G_J Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.66 63.9 29.4 Yes No
2 empty 1.99 57.2 26.5 No No
3 empty 2.32 65 14.5 No No
4 empty 2.14 56.2 17.8 No No
5 empty 2.3 63.7 17.8 No No
6 empty 1.81 34.2 14.5 No No
7 empty 2.2 58.7 15.4 No No
8 empty 2.55 61.9 11 No No
9 empty 2.48 65.1 9.4 No No
10 empty 1.74 66.9 8.2 No No
2RCT_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.42 99.5 0 Yes Yes
2 empty 2.58 67.5 20.8 No No
3 empty 2.25 61 14.4 No No
4 bound 2.41 70.2 16.4 No No
5 empty 2.68 57.8 16.8 No No
6 empty 2.33 68.5 10.2 No No
7 empty 2.53 66.5 9.2 No No
8 empty 2.13 59.2 10.8 No No
9 empty 2.62 59.4 16.4 No No
10 empty 1.84 63.4 7.2 No No
4GKC_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.2 99.8 0 Yes Yes
2 empty 2.39 66.9 20.3 No No
3 empty 1.98 64.6 13.2 No No
4 empty 2.3 65.5 13.8 No No
5 empty 2.2 61.9 15.8 No No
6 empty 2.37 69 9.8 No No
7 empty 2.6 65.2 8.9 No No
8 empty 2.49 57.6 10.2 No No
9 empty 2.49 76.4 6.9 No No
10 empty 2.47 53.1 7.7 No No
4ZGU_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 87 20.2 Yes Yes
2 empty 2.29 67.2 15.4 No No
3 empty 2.78 64.7 10.8 No No
4 empty 2.32 68.7 11.1 No No
5 empty 2.51 66.3 11.7 No No
6 empty 2.07 61 9.3 No No
7 empty 2.72 65.7 8.3 No No
8 empty 2.55 58 10 No No
9 empty 2.7 70.6 5.7 No No
10 empty 2.49 64.1 8.5 No No
4EFG_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.5 84.3 25.1 Yes Yes
2 empty 2.21 66.8 18.5 No No
3 empty 2.33 69.4 11.8 No No
4 empty 2.5 68.4 15.2 No No
5 empty 2.66 64.8 11.4 No No
6 empty 1.85 63.4 11.2 No No
7 empty 2.56 65.7 7.4 No No
8 empty 2.48 57.3 11.6 No No
9 empty 2.5 64.1 8.4 No No
10 empty 2.32 50 7.9 No No
4ZCB_A Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 63.9 29.4 Yes No
2 empty 2.11 57.6 28.8 No No
3 empty 2.31 62.9 16.5 No No
4 empty 2.5 60.4 18.4 No No
5 empty 1.96 69 10.4 No No
6 empty 1.84 63 14.5 No No
7 empty 3.08 64.9 14.7 No No
8 empty 1.39 20.6 10.5 No No
9 empty 1.9 69.9 7.7 No No
10 empty 2.58 62 9.3 No No
5DG4_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 86.8 21.6 Yes Yes
2 empty 2.35 62.3 21.1 No No
3 empty 2.08 68 16.1 No No
4 empty 2.98 60.2 11.6 No No
5 empty 2.6 65.3 13.4 No No
6 empty 2.54 62.6 10.8 No No
7 empty 2.12 61.4 10.2 No No
8 empty 2.2 68.6 7.7 No No
9 empty 2.02 73.3 6.6 No No
10 empty 2.77 60.5 11.5 No No
4RUU_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.32 99.4 0 Yes Yes
2 empty 2.38 65.5 17.2 No No
3 empty 2.19 63.3 11 No No
4 empty 2.16 62.1 11.1 No No
5 empty 2.27 65.8 10.9 No No
6 empty 2.76 61.8 9.4 No No
7 empty 2.77 67.9 11.5 No No
8 empty 2.21 62.3 7.7 No No
9 empty 2.32 70.6 6.8 No No
10 empty 2.74 63.8 9.8 No No
5U6G_B Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 63.9 30.2 Yes No
2 empty 2.51 62.3 26.1 No No
3 empty 2.3 55 26.5 No No
4 empty 1.92 57.4 15 No No
5 empty 2.18 70.8 9.9 No No
6 empty 3.08 61.8 15.2 No No
7 empty 1.97 62.8 8.7 No No
8 empty 1.83 60.6 9.5 No No
9 empty 2.9 57.5 9.5 No No
10 empty 1.42 15.9 9.4 No No
6E5S_A Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.63 64.2 28.2 Yes No
2 empty 1.8 55.6 26.3 No No
3 empty 2.59 58 22.6 No No
4 empty 2.47 68.5 18.1 No No
5 empty 1.76 63.9 12.9 No No
6 empty 1.91 63.2 13.7 No No
7 empty 2.13 60.3 10.2 No No
8 empty 2.98 56.7 11.1 No No
9 empty 1.62 22.6 13.6 No No
10 empty 2.53 71.3 8.2 No No
6BTH_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 99.2 0 Yes Yes
2 empty 2.02 58.2 17.6 No No
3 empty 1.78 53 13.4 No No
4 empty 2.4 72.2 10.1 No No
5 empty 2.23 55.3 11.3 No No
6 empty 2.09 58.9 12.5 No No
7 empty 2.34 68.5 8.2 No No
8 empty 2.53 65.2 12 No No
9 empty 2.43 71.1 8.8 No No
10 empty 2.02 71.7 6.2 No No
4ZH9_A Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 62.1 30.7 Yes No
2 empty 1.97 56.5 18.1 No No
3 empty 2.26 65 19.3 No No
4 empty 2.39 55.3 20.7 No No
5 empty 2.21 60.9 14.7 No No
6 empty 1.83 63.7 14.2 No No
7 empty 3.07 67.5 15.4 No No
8 empty 1.5 17.4 10.3 No No
9 empty 1.99 50 9.7 No No
10 empty 1.83 64.4 7.7 No No
5F58_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 88.1 23.5 Yes Yes
2 empty 2.33 64.1 16.6 No No
3 empty 2.09 70.5 8 No No
4 empty 2.52 62.7 13.7 No No
5 empty 2.9 59.1 11.4 No No
6 empty 2.29 63.6 8.9 No No
7 empty 2.28 61.7 7.8 No No
8 empty 2.67 60.3 11.7 No No
9 empty 2.04 68.1 7.6 No No
10 empty 2.17 58.9 7.7 No No
4QYP_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 99.2 0 Yes Yes
2 empty 2.31 65.8 18 No No
3 empty 2.25 69.5 11.3 No No
4 empty 2.18 61.8 8.8 No No
5 empty 2.78 58.1 12.2 No No
6 empty 2.26 67.7 11.3 No No
7 empty 2.55 66.9 8.3 No No
8 empty 2.45 59.6 11.1 No No
9 bound 2.64 69.8 11.3 No No
10 bound 2.58 67 10.3 No No
5FEN_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.26 90.2 22.4 Yes Yes
2 empty 2.35 64.8 18 No No
3 empty 2.19 68.1 10.5 No No
4 empty 2.66 65.9 13.8 No No
5 empty 2.14 66.8 9.8 No No
6 empty 2.61 64.7 9.8 No No
7 empty 2.28 57.3 10.6 No No
8 empty 2.55 66.3 6.3 No No
9 empty 2.05 71.2 6.2 No No
10 empty 2.58 73.2 5.9 No No
5F7G_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.34 81.6 25.3 Yes Yes
2 empty 2.24 64.4 19.1 No No
3 empty 2.16 56.1 13.1 No No
4 empty 2.36 64.2 13.3 No No
5 empty 2.5 65.9 9.5 No No
6 empty 2.56 71.8 9 No No
7 empty 2.37 67.7 7.6 No No
8 empty 2.64 61.7 9.1 No No
9 empty 2.52 60.2 11.1 No No
10 empty 1.87 70.2 8 No No
6E5S_I Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 62.3 31.8 Yes No
2 empty 2.73 55.1 35.3 No No
3 empty 1.96 57.6 27 No No
4 empty 1.86 57.3 20.7 No No
5 empty 2.26 69.2 13.1 No No
6 empty 2.32 63.2 12.2 No No
7 empty 1.91 57.7 13.9 No No
8 empty 2.46 68.9 7.9 No No
9 empty 3.38 62.4 9 No No
10 empty 2.74 76.6 7.2 No No
6E5S_L Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 62.3 29 Yes No
2 empty 2.18 59.6 27.3 No No
3 empty 2.52 57.4 22.6 No No
4 empty 2.07 62.3 21 No No
5 empty 2.35 65.7 16 No No
6 empty 2.29 72.4 8.9 No No
7 empty 1.82 38.9 12.5 No No
8 empty 3.05 60.5 10.4 No No
9 empty 2.3 68.2 9.4 No No
10 empty 1.76 53 7 No No
4EEJ_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.19 99.6 0 Yes Yes
2 empty 2.23 63.7 17.2 No No
3 empty 1.87 62.6 18.5 No No
4 empty 2.1 68.1 13 No No
5 empty 2.04 60.2 13.7 No No
6 empty 2.34 70.7 10 No No
7 empty 2.45 65.8 8.6 No No
8 empty 2.08 74.7 5.7 No No
9 empty 2.53 59.8 10.4 No No
10 empty 2.66 65.1 6.9 No No
6C7Z_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 88 23 Yes Yes
2 empty 2.42 64.3 19 No No
3 empty 1.91 70.3 8.9 No No
4 empty 2.62 63 13.7 No No
5 empty 2.56 67.8 9.7 No No
6 empty 2.17 67.1 7.8 No No
7 empty 2.4 54.4 13.5 No No
8 empty 2.67 61 11.1 No No
9 empty 2.43 64.5 6.8 No No
10 empty 2.41 63.8 8.1 No No
5FFH_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 83 24.3 Yes Yes
2 empty 2.11 64.3 17.3 No No
3 empty 2.33 65.6 13.2 No No
4 empty 2.54 70.9 8.4 No No
5 empty 2.31 62.2 10.7 No No
6 empty 2.07 64.9 7.5 No No
7 empty 2.87 64.1 8.5 No No
8 empty 2.11 74.4 6.4 No No
9 empty 2.5 54.2 7.1 No No
10 empty 2.93 56 7.6 No No
4RUU_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 91.6 23.3 Yes Yes
2 empty 2.13 67.8 16.3 No No
3 empty 2.08 68.7 13.8 No No
4 empty 2.23 63.1 12.2 No No
5 empty 2.4 70.6 10 No No
6 empty 2.17 69.3 8.1 No No
7 empty 2.55 58.6 6.8 No No
8 empty 2.33 63.8 8.4 No No
9 empty 2.68 66.2 8.7 No No
10 empty 2.9 61.1 6.3 No No
6BTH_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.36 98.4 0 Yes Yes
2 empty 2.4 67.4 22.2 No No
3 bound 2.28 62.6 17.3 No No
4 bound 2.16 65.2 14.4 No No
5 empty 2.49 57.8 15.4 No No
6 empty 2.35 62.2 13.8 No No
7 empty 2.54 59.9 13.7 No No
8 empty 2.02 66.9 9.5 No No
9 empty 2.36 66.5 9.6 No No
10 empty 2.25 46.4 15.7 No No
4QZT_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 98.8 0 Yes Yes
2 empty 2.5 66.7 19.2 No No
3 empty 2.42 67.7 10.6 No No
4 empty 2.18 61.7 12.8 No No
5 empty 2.44 62.6 12.1 No No
6 empty 2.63 61.6 11.5 No No
7 empty 2.55 60.8 14.5 No No
8 empty 2.14 70.8 7 No No
9 empty 2.19 66.7 10 No No
10 empty 2.02 69.4 8.9 No No
5U6G_I Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 63.4 29.6 Yes No
2 empty 2.04 54.9 28.4 No No
3 empty 2.45 65.3 15.8 No No
4 empty 2.15 55.9 17.6 No No
5 empty 2.56 51.2 18.7 No No
6 empty 2.29 69.9 9.9 No No
7 empty 2.1 66.5 8.5 No No
8 empty 1.54 28.3 9.7 No No
9 empty 2.37 52 9.4 No No
10 empty 1.59 64.1 9.5 No No
6BTI_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.37 98.1 0 Yes Yes
2 empty 2.12 61.7 20.2 No No
3 empty 2.38 67.7 12.6 No No
4 bound 2.26 61.4 17.3 No No
5 bound 2.08 63.2 18.7 No No
6 empty 2.2 62.6 11.4 No No
7 empty 2.33 60.9 14.7 No No
8 empty 2.21 59.2 11.4 No No
9 empty 2.4 64.2 12.7 No No
10 empty 2.45 61.2 13.7 No No
4EDE_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.23 99.2 0 Yes Yes
2 empty 2.39 68.5 15 No No
3 empty 2.18 69.8 10 No No
4 empty 2.35 63.1 15.3 No No
5 empty 2.06 62.4 14.1 No No
6 empty 2.48 73 8.6 No No
7 empty 1.81 60.1 9.7 No No
8 empty 2.37 62.5 8.9 No No
9 empty 2.38 68.7 7.9 No No
10 empty 2.36 73.8 6.5 No No
5DPQ_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 68 30 Yes Yes
2 empty 1.93 58.1 26.8 No No
3 empty 2.13 57.7 15 No No
4 empty 2.46 61 22.5 No No
5 empty 2.11 64 23.9 No No
6 empty 2.24 56.7 20.8 No No
7 empty 3.15 65.4 15.2 No No
8 empty 1.56 20 13 No No
9 empty 2.48 56.3 11.7 No No
10 empty 1.95 68.9 7.8 No No
4QYN_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 98.6 0 Yes Yes
2 empty 2.09 64.5 16.8 No No
3 empty 2.26 68.6 16.1 No No
4 empty 2.52 60.7 11.6 No No
5 empty 2.44 60.1 11.3 No No
6 empty 2.1 61.8 9.1 No No
7 empty 2.21 67.5 7.9 No No
8 empty 2.5 68.3 10.4 No No
9 empty 2.18 65.9 10.7 No No
10 empty 2.64 58.3 7.9 No No
5U6G_G Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 63.6 29.8 Yes No
2 empty 2.13 58.1 26.2 No No
3 empty 2.46 63.9 18.5 No No
4 empty 2.28 71.3 12.2 No No
5 empty 2.43 58 15.7 No No
6 empty 2.36 66.2 13.1 No No
7 empty 2.13 57.5 16.1 No No
8 empty 1.41 26.2 12.4 No No
9 empty 1.75 65.2 11.5 No No
10 empty 3.19 62.6 14.2 No No
4QZU_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.45 99.4 0 Yes Yes
2 empty 2.2 68.5 17.6 No No
3 empty 2.56 69.4 8.7 No No
4 bound 2.55 63 14.7 No No
5 empty 2.3 60.9 10.2 No No
6 empty 2.75 59.1 10.2 No No
7 empty 2.06 69.2 6.9 No No
8 empty 2.7 62 14.4 No No
9 empty 2.21 68.9 9.4 No No
10 empty 2.21 69 6.2 No No
5U6G_L Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 65.2 29.5 Yes No
2 empty 2.12 56.8 27.1 No No
3 empty 2.47 55 15.6 No No
4 empty 2.68 61.9 24 No No
5 empty 2.17 71.9 9.5 No No
6 empty 2.14 33 14.4 No No
7 empty 2 59.6 16.7 No No
8 empty 2.27 64.6 16.8 No No
9 empty 2.2 66.7 9.6 No No
10 empty 3.2 65.2 11.3 No No
5DG4_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.61 89.6 19.4 Yes Yes
2 empty 2.42 65.2 18.5 No No
3 empty 2.29 66.8 13.3 No No
4 empty 2.16 65 12.6 No No
5 empty 2.49 66.2 12.2 No No
6 empty 2.14 68.9 6.4 No No
7 empty 2.35 60.9 13.7 No No
8 empty 2.98 67.9 10 No No
9 empty 2.1 67.9 9.6 No No
10 empty 2.19 71.1 6.2 No No
4QZU_C Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 99 0 Yes Yes
2 empty 2.24 60.8 15.2 No No
3 empty 1.7 63.3 12.4 No No
4 empty 2.62 67.1 9.3 No No
5 empty 2.85 59.6 17.2 No No
6 empty 2.06 63.1 8.2 No No
7 empty 2.45 65.4 13.1 No No
8 empty 2.6 60.2 15 No No
9 empty 2.33 68.9 11.7 No No
10 empty 2.07 72.8 6.6 No No
4QZT_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 98.4 0 Yes Yes
2 empty 2.39 64 18.5 No No
3 empty 1.84 59.4 15.6 No No
4 empty 2.57 64.8 13.2 No No
5 empty 2.45 63.3 13.6 No No
6 empty 2.69 62 7.3 No No
7 empty 2.21 53.8 11.9 No No
8 empty 2.29 69.1 8.5 No No
9 empty 2.31 65.8 7.5 No No
10 empty 1.92 61.9 7.8 No No
5FAZ_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 98 0 Yes Yes
2 empty 2.37 68.2 16 No No
3 empty 2.23 73.2 16.8 No No
4 empty 2.36 62.7 13.7 No No
5 empty 2.11 62.8 8.4 No No
6 empty 2.15 72.5 7.8 No No
7 empty 2.72 63.2 11 No No
8 empty 2.27 57.1 10.8 No No
9 empty 2.22 69.3 6.2 No No
10 empty 2.47 64.7 9 No No
4ZGU_D Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 90.8 20.3 Yes Yes
2 empty 2.07 82.7 17.2 Yes Yes
3 empty 2.26 68.6 16.5 No No
4 empty 2.66 60.2 13.6 No No
5 empty 2.24 61.9 8.7 No No
6 empty 2.24 57.6 9.9 No No
7 empty 2.25 60.1 10.4 No No
8 empty 2.65 63.6 9.3 No No
9 empty 2.29 63 6.2 No No
10 empty 2.66 63.1 10.5 No No
6C7Z_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.44 86.3 24.7 Yes Yes
2 empty 2.41 68.3 17.2 No No
3 empty 1.88 62.1 14 No No
4 empty 2.31 67.5 14.1 No No
5 empty 2.23 59.2 10.8 No No
6 empty 2.58 68.1 8.9 No No
7 empty 2.83 65.8 9 No No
8 empty 2.63 57.7 11.8 No No
9 empty 2.15 73.7 5.8 No No
10 empty 1.62 48.4 8.1 No No
4EXZ_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 99.4 0 Yes Yes
2 empty 2.13 67.4 14.5 No No
3 empty 1.88 64.1 15.6 No No
4 empty 1.58 65.5 12.8 No No
5 empty 2.4 66.2 11.5 No No
6 empty 2.45 66.8 9.7 No No
7 empty 2.45 59.8 10.7 No No
8 empty 2.78 61.5 14.1 No No
9 empty 2.3 64.9 7.4 No No
10 empty 2.35 61.4 10.7 No No
5U6G_A Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 63.9 28 Yes No
2 empty 2.43 54.3 36.7 No No
3 empty 1.79 58 19.6 No No
4 empty 2.28 66.4 19.7 No No
5 empty 1.99 56.9 17.1 No No
6 empty 2.22 53.9 14.6 No No
7 empty 3.03 56 15.9 No No
8 empty 2.4 67.3 10.4 No No
9 empty 2.02 67.8 6.7 No No
10 empty 1.33 73.4 6.1 No No
6E5S_G Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.45 62.5 32.9 Yes No
2 empty 2.01 57.4 26.3 No No
3 empty 2.28 51.3 28.2 No No
4 empty 1.91 56.9 25.8 No No
5 empty 2.17 66.5 9.8 No No
6 empty 3 58.2 16.2 No No
7 empty 2.35 70.5 7.9 No No
8 empty 2.1 65.2 8.8 No No
9 empty 2.59 64.3 5.9 No No
10 empty 2.67 67.7 7.6 No No
4ZR2_A Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 59.1 36.6 Yes No
2 empty 2.12 54.5 26.2 No No
3 empty 2.3 64.3 14.9 No No
4 empty 2.07 67.1 15.3 No No
5 empty 2.02 57.7 23.5 No No
6 empty 1.99 47.2 14.2 No No
7 empty 3.15 61.1 14.8 No No
8 empty 2.17 55.7 9.3 No No
9 empty 2.33 61.5 6.2 No No
10 empty 2.7 61.8 6.5 No No
4EFG_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 94.6 17 Yes Yes
2 empty 2.41 68.1 21.9 No No
3 empty 1.86 66.9 9.7 No No
4 empty 2.29 66.1 13.2 No No
5 empty 2.25 68.6 9.7 No No
6 empty 2.42 69.5 7.6 No No
7 empty 2.52 61.1 14.2 No No
8 empty 1.93 67.9 9.2 No No
9 empty 2.13 75.4 5.9 No No
10 empty 2.49 71.8 7.1 No No
4QZT_C Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 98.3 0 Yes Yes
2 empty 2.12 63.3 15.6 No No
3 empty 1.95 64.2 12.6 No No
4 empty 2.47 67 10 No No
5 empty 2.25 62.6 9.9 No No
6 empty 2.27 65.4 13.8 No No
7 empty 2.87 59.7 13.1 No No
8 empty 2.25 71.1 10.2 No No
9 empty 2.47 67.4 7.7 No No
10 empty 2.65 65.9 8.9 No No
4ZJ0_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.38 99.3 0 Yes Yes
2 empty 2.5 69.4 17.2 No No
3 empty 2.12 61.8 15.7 No No
4 empty 2.64 59.4 13.6 No No
5 empty 2.26 63.6 10.8 No No
6 empty 2.35 66.9 7.1 No No
7 empty 2.3 62.4 9 No No
8 empty 2.04 74.2 6.1 No No
9 empty 2.36 73.7 9.2 No No
10 empty 2.97 65.9 8.8 No No
5F6B_A Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 82 24.9 Yes Yes
2 empty 2.17 66.9 18 No No
3 empty 2.5 63.3 17 No No
4 empty 2.05 62.6 10.9 No No
5 empty 2.3 64.6 11.9 No No
6 empty 2.45 69.1 8.8 No No
7 empty 2.42 69.5 7.9 No No
8 empty 2.33 61.5 10.3 No No
9 empty 2.68 65 14.5 No No
10 empty 2.31 56.9 10.3 No No
6BTI_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.35 98.8 0 Yes Yes
2 empty 2.09 59.3 16.4 No No
3 empty 1.79 54.2 13.3 No No
4 empty 2.44 70.3 10.9 No No
5 empty 2.33 58.2 10 No No
6 empty 2.25 69.5 9.5 No No
7 empty 2.46 64.7 14.1 No No
8 empty 2.04 55.7 11.7 No No
9 empty 2.27 64.3 12.6 No No
10 empty 2.41 61.9 12.3 No No
4QYP_D Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.42 86 21.1 Yes Yes
2 empty 2.32 69 19.1 No No
3 empty 2.04 66.8 8.7 No No
4 empty 2.58 73.5 9.8 No No
5 empty 2.35 63.5 14.6 No No
6 empty 2.74 59.1 11.7 No No
7 empty 2.58 60.2 15.9 No No
8 empty 2.19 64.6 9.4 No No
9 empty 2.83 57.7 10 No No
10 empty 1.99 62 7.2 No No
4GKC_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.11 99.5 0 Yes Yes
2 empty 2 66.1 12.1 No No
3 empty 2.13 63.7 15.6 No No
4 empty 2.15 71.4 12.6 No No
5 empty 2.16 64.7 10.4 No No
6 empty 2.39 59.9 9.6 No No
7 empty 2.4 69.4 13.5 No No
8 empty 2.6 65.5 9.4 No No
9 empty 2.45 56.6 12.5 No No
10 empty 2.04 60.4 12.1 No No
5F7G_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 86.3 22.2 Yes Yes
2 empty 2.08 68.8 11.6 No No
3 empty 1.88 67.6 10.9 No No
4 empty 2.18 65.1 12 No No
5 empty 2.54 61.5 11.9 No No
6 empty 2.9 57.3 17.9 No No
7 empty 1.98 57.1 10.6 No No
8 empty 2.01 53 8.8 No No
9 empty 2.95 62.9 11.3 No No
10 empty 2.51 67.9 7.6 No No
6E5S_B Retinol-binding protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 69.3 30 Yes Yes
2 empty 2.06 57.9 26.3 No No
3 empty 2.44 65.1 19 No No
4 empty 1.84 59.4 21.1 No No
5 empty 2.5 56.3 17 No No
6 empty 2.25 63.8 12.6 No No
7 empty 1.94 57.6 10 No No
8 empty 1.8 23.4 14.6 No No
9 empty 3.07 61.8 11.2 No No
10 empty 2.18 70.3 11 No No
5U6G_C Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.65 64.2 30.7 Yes No
2 empty 2.76 61.5 30.7 No No
3 empty 1.71 55.5 26.1 No No
4 empty 2.3 67.4 20.7 No No
5 empty 1.45 58.6 15.3 No No
6 empty 2.93 61.5 11.1 No No
7 empty 1.47 21.1 11.2 No No
8 empty 1.66 58.9 10.2 No No
9 empty 2.04 62.7 8.3 No No
10 empty 2.71 60.8 8.5 No No
5U6G_E Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 64.7 29.3 Yes No
2 empty 2.18 55.2 26.1 No No
3 empty 2.8 55.2 21.7 No No
4 empty 2.07 56.4 18.4 No No
5 empty 2.32 64.2 16 No No
6 empty 1.79 37 16.4 No No
7 empty 1.85 57.3 12.7 No No
8 empty 2.09 66.5 9.9 No No
9 empty 2.17 65.9 9.5 No No
10 empty 2.48 53.3 10.1 No No
4ZCB_B Retinol-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 63.3 31.7 Yes No
2 empty 2 58.1 26.7 No No
3 empty 2.07 59.6 24 No No
4 empty 2.27 70.9 17.2 No No
5 empty 2.6 57.8 8.5 No No
6 empty 3.11 72.3 6.6 No No
7 empty 3.02 59.4 12 No No
8 empty 3.35 71.1 5.6 No No
9 empty 3.24 63.5 7.8 No No
10 empty 2.81 54.5 8.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria2
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2RCQ_A (3200468) Retinol-binding protein 2 Lipocalins, Lipocalins, Fatty acid binding protein-like 1.2Å Yes Yes
2RCT_A (3200469) Retinol-binding protein 2 Lipocalins, Lipocalins, Fatty acid binding protein-like 1.2Å Yes Yes
Ligand-based Druggability Score: -0.65
Ligand-based Druggability Score Percentile: 72%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


RBP2 is involved in 4 interactions in the network.


Druggability
Overall Druggability Percentile: 58.70
Druggability for Cancer Therapeutics: 66.80
Druggability for Other Therapeutics: 50.17
Cancer-Associated
Cancer-associated percentile : 47.97
Network Articulation Point
Is RBP2 critical for communication in the network?


Detailed Graph Legend:Help