Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RBP2 (P50120) - Overview - Molecular Target Synopsis

Protein


RBP2, Retinol-binding protein 2
UniProt P50120

Also Known as RET2_HUMAN, RBP2, CRBP2

Intracellular transport of retinol.

6BTI
CRYSTAL STRUCTURE OF HUMAN CELLULAR RETINOL BINDING PROTEIN 2 (CRBP2) IN COMPLEX WITH N-ARACHIDONOYLETHANOLAMINE (AEA)
RCSB/PDB
Inspect Structure
See all 3D Structures for RBP2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RBP2 is active in the following subcellular-locations: cytoplasm.
GO terms: RBP2 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RBP2 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, HCC_2998, HCT_116

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C2BBe1, OVSAHO, SNU-C1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For RBP2 there are:
30 structures (76 chains) solved
24 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

RBP2 is solved in complex with the approved drug(s):

RTL/RETINOL (2RCT_A, 4QYN_A, 4QYN_B, 4QZT_A, 4QZT_C, 4QZU_A, 4QZU_B, 4QZU_C).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RBP2 has been screened with compounds ( bioactivities). (see details)