Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

CLK3 (P49761) - Overview - Molecular Target Synopsis


CLK3, Dual specificity protein kinase CLK3
Enzyme Classification
UniProt P49761

Also Known as CLK3_HUMAN, CLK3

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

X-RAY STRUCTURE OF CLK3-KD(GP-[275-632], NON-PHOS.)/CX-4945 AT 2.29A
Inspect Structure
See all 3D Structures for CLK3

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: CLK3 is active in the following subcellular-locations: acrosome, cytoplasm, cytoplasmic vesicle, nucleus, nucleus speckle, secretory vesicle.
GO terms: CLK3 is active in the following subcellular-locations: acrosomal vesicle, intermediate filament cytoskeleton, membrane, nuclear speck, nucleoplasm, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project CLK3 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: KM12, HCC_2998, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-C1, OCUM-1, SUM 1315M02

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, GM12878

(see details)

RNA Interference

CLK3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HOSMNNG, BT20. (see details)

3D Structures

For CLK3 there are:
8 structures (10 chains) solved
6 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

CLK3 has been screened with 806 compounds (1481 bioactivities), 12 compounds have bioactivities that show binding affinity of <= 500nM (12 bioactivities). (see details)