Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CLK3 (P49761) - Overview - Molecular Target Synopsis

Protein


CLK3, Dual specificity protein kinase CLK3
Enzyme Classification 2.7.12.1
UniProt P49761

Also Known as CLK3_HUMAN, CLK3

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

6KHF
CRYSTAL STRUCTURE OF CLK3 IN COMPLEX WITH CX-4945
RCSB/PDB
Inspect Structure
See all 3D Structures for CLK3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CLK3 is active in the following subcellular-locations: acrosome, cytoplasm, cytoplasmic vesicle, nucleus, nucleus speckle, secretory vesicle.
GO terms: CLK3 is active in the following subcellular-locations: acrosomal vesicle, intermediate filament cytoskeleton, membrane, nuclear speck, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CLK3 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, HCC_2998, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-C1, OCUM-1, SUM 1315M02

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, GM12878

(see details)

RNA Interference


CLK3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HOSMNNG, BT20. (see details)

3D Structures


For CLK3 there are:
10 structures (13 chains) solved
8 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CLK3 has been screened with 943 compounds (1662 bioactivities), 17 compounds have bioactivities that show binding affinity of <= 500nM (20 bioactivities). (see details)