Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL4D (P49703) - Overview - Molecular Target Synopsis

Protein


ARL4D, ADP-ribosylation factor-like protein 4D
UniProt P49703

Also Known as ARL4D_HUMAN, ARL4D, ARF4L

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. Interacts with CYTH2; the interaction is direct and ARL4D GTP-dependent. Does not interact with ARL4D.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
225ENSG00000175906ENST00000320033ENSP00000322628

Sub-cellular localization


UniProt: ARL4D is active in the following subcellular-locations: cell membrane, cytoplasm, nucleolus, nucleus.
GO terms: ARL4D is active in the following subcellular-locations: cytoplasm, nucleolus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL4D has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H460, NCI_ADR_RES, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COV434, NCI-H82, G112

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, HMEC

(see details)

3D Structures


At greater than 35% identity similarity to ARL4D there are:
83 structures (169 chains) solved
72 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL4D has been screened with compounds ( bioactivities). (see details)