CSNK1E (P49674) - Overview - Molecular Target Synopsis
CSNK1E, Casein kinase I isoform epsilon
Enzyme Classification 188.8.131.52
Also Known as KC1E_HUMAN, CSNK1E
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. Monomer (PubMed:23106386). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (By similarity). Interacts with PER1 (PubMed:10790862). Interacts with ANKRD6 (By similarity). Interacts with DBNDD2 (PubMed:16618118). Interacts with LRP5 and LRP6 (PubMed:16513652). Interacts with SOCS3 (PubMed:15070676). Interacts with SNAI1 (via zinc fingers) (PubMed:20305697). Interacts with DDX3X; the interaction greatly improves CSNK1E affinity for ATP and enhances DVL2 phosphorylation (PubMed:23413191).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|416||ENSG00000213923||ENST00000359867, ENST00000403904, ENST00000400206, ENST00000396832||ENSP00000352929, ENSP00000384074, ENSP00000383067, ENSP00000380044||P49674-1|
UniProt: CSNK1E is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: CSNK1E is active in the following subcellular-locations: cytoplasm, cytosol, nucleoplasm, nucleus.