Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
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Gene Copy Number Variation
RNAi
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Germline Genetics

CDK8 (P49336) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3PXR_A 38.27 9.0E-50 2Å - 2011-02-16
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 1OIT_A 38.27 8.0E-50 1.6Å HDT 2003-09-04
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q4B_A 38.27 9.0E-50 1.12Å HHN 2019-03-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4EOR_C 38.27 9.0E-50 2.2Å 4SP 2013-02-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1OIU_C 38.27 9.0E-50 2Å N76 2004-07-13
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4CFN_A 38.27 9.0E-50 2.2Å JYM 2013-12-18
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3ROY_A 38.27 9.0E-50 1.75Å 22Z 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 5OSJ_A 38.27 8.0E-50 1.83Å AAK 2018-03-14
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4EOM_A 38.27 1.0E-49 2.1Å ATP 2013-02-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2WXV_C 38.27 1.0E-49 2.6Å WXV 2010-02-23
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1OIY_C 38.27 9.0E-50 2.4Å N41 2004-07-13
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4CFW_A 38.27 8.0E-50 2.45Å SQ9 2013-12-18
Protein kinase domain (99%) (view alignment) CDK1 (P06493) CKS1B (P61024) HUMAN 4YC6_A 37.46 3.0E-50 2.6Å - 2015-05-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 5IF1_C 38.27 1.0E-49 2.61Å - 2016-04-27
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4EOM_C 38.27 1.0E-49 2.1Å ATP 2013-02-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q48_A 38.27 9.0E-50 1.03Å HHQ 2019-03-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R7U_A 38.27 9.0E-50 1.75Å X96 2012-08-08
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 4F6U_A 100 0 2.1Å 0SR 2013-05-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) 2WMB_C 38.27 8.0E-50 2.5Å - 2010-09-01
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 4CRL_A 100 0 2.4Å C1I 2015-09-23
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 4F7J_A 100 0 2.6Å 0SU 2013-05-01
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5HBJ_A 100 0 3Å 5Y8 2016-02-03
Protein kinase domain (99%) (view alignment) CDK1 (P06493) CKS2 (P33552), CCNB1 (P14635) HUMAN 4YC3_A 37.46 3.0E-50 2.7Å - 2016-04-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QX2_A 38.27 9.0E-50 1.75Å X63 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2WIH_C 38.27 1.0E-49 2.5Å P48 2009-07-28
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CDKN1B (P46527), CCNA2 (P20248) HUMAN 1H27_A 38.27 8.0E-50 2.2Å - 2003-02-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R9H_A 38.27 9.0E-50 2.1Å Z67 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3SQQ_A 38.27 9.0E-50 1.85Å 99Z 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q4F_A 38.27 9.0E-50 1.21Å 26D OCS 2019-03-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QWJ_A 38.27 9.0E-50 1.75Å X6A 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P30274) HUMAN 6GUC_A 38.27 9.0E-50 2Å SU9 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QXP_A 38.27 9.0E-50 1.75Å X64 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 4EZ7_A 38.27 9.0E-50 2.49Å STU 2AN 2012-08-22
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2IW8_A 38.27 6.0E-50 2.3Å 4SP 2006-09-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R7E_A 38.27 9.0E-50 1.9Å X88 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) Ccna2 (P51943) HUMAN 4I3Z_C 38.27 9.0E-50 2.05Å ADP 2012-12-26
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QXO_A 38.27 9.0E-50 1.75Å X65 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QTZ_A 38.27 9.0E-50 2Å X42 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2WIP_C 38.27 1.0E-49 2.8Å P49 2009-07-28
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P30274) HUMAN 4BCQ_A 38.27 9.0E-50 2.19Å TJF 2013-01-09
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) 2WMA_C 38.27 8.0E-50 2.8Å - 2010-09-01
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5IDN_A 100 0 2.26Å 6A7 2016-12-21
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3PXQ_A 38.27 9.0E-50 1.9Å 2AN 2011-02-16
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1H1S_C 38.27 8.0E-50 2Å 4SP 2002-09-19
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4EOS_A 38.27 9.0E-50 2.57Å 1RO 2013-02-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P30274) HUMAN 4BCQ_C 38.27 9.0E-50 2.19Å TJF 2013-01-09
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q4H_A 38.27 9.0E-50 1Å HGH 2019-03-20
Protein kinase domain (99%) (view alignment) CDK1 (P06493) CKS2 (P33552), CCNB1 (P14635) HUMAN 4Y72_A 37.46 3.0E-50 2.3Å LZ9 2015-08-12
Protein kinase domain (99%) (view alignment) CDK1 (P06493) CCNB1 (P14635), (K9J4F7) HUMAN 6GU4_A 37.46 3.0E-50 2.73Å FC8 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q3F_A 38.27 9.0E-50 1.18Å HEW OCS 2019-03-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RAH_A 38.27 9.0E-50 1.75Å O1Z 2012-10-31
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 4F7L_A 100 0 2.9Å 0SO 2013-05-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2IW8_C 38.27 6.0E-50 2.3Å 4SP 2006-09-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QQG_A 38.27 9.0E-50 1.9Å X06 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R71_A 38.27 9.0E-50 1.75Å X86 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) E2F1 (Q01094), CCNA2 (P20248) HUMAN 1H24_C 38.27 8.0E-50 2.5Å - 2003-02-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) TP53 (P04637), CCNA2 (P20248) HUMAN 1H26_C 38.27 8.0E-50 2.24Å - 2003-02-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1OGU_A 38.27 9.0E-50 2.6Å ST8 2003-09-02
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QRT_A 38.27 9.0E-50 1.75Å X14 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QTW_A 38.27 9.0E-50 1.85Å X3A 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P30274) HUMAN 6GUF_A 38.27 9.0E-50 2.65Å 23D 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3PXZ_A 38.27 9.0E-50 1.7Å JWS 2AN 2011-02-16
Protein kinase domain (99%) (view alignment) CDK1 (P06493) CKS1B (P61024) HUMAN 4YC6_G 37.46 3.0E-50 2.6Å - 2015-05-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q4K_A 38.27 9.0E-50 1.06Å HHW 2019-03-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RM6_A 38.27 9.0E-50 1.6Å 18Z 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4EOO_C 38.27 1.0E-49 2.1Å ATP 2013-02-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4EOP_C 38.27 9.0E-50 1.99Å 1RO 2013-02-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1H1P_C 38.27 8.0E-50 2.1Å CMG 2002-09-19
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2WPA_C 38.27 1.0E-49 2.5Å 889 2010-02-23
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6GUK_A 38.27 9.0E-50 1.3Å FC8 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QU0_A 38.27 9.0E-50 1.95Å X40 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QZI_A 38.27 9.0E-50 1.75Å X72 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1E9H_A 38.27 9.0E-50 2.5Å INR 2001-10-11
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RAK_A 38.27 9.0E-50 1.75Å 03Z 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QTX_A 38.27 9.0E-50 1.95Å X43 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QWK_A 38.27 9.0E-50 1.85Å X62 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4CFW_C 38.27 8.0E-50 2.45Å SQ9 2013-12-18
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P30274) HUMAN 6GUE_C 38.27 9.0E-50 1.99Å FB8 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R73_A 38.27 9.0E-50 1.7Å X87 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2WPA_A 38.27 1.0E-49 2.5Å 889 2010-02-23
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RMF_A 38.27 9.0E-50 1.75Å 20Z 2012-10-31
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5IDP_A 100 0 2.65Å 6A6 2016-12-21
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R8L_A 38.27 9.0E-50 1.9Å Z30 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R9N_A 38.27 9.0E-50 1.75Å Z68 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) TP53 (P04637), CCNA2 (P20248) HUMAN 1H26_A 38.27 8.0E-50 2.24Å - 2003-02-01
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5HNB_A 100 0 2.35Å 62M 2016-04-27
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 5JQ8_A 38.27 1.0E-49 1.94Å I73 2017-02-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R7V_A 38.27 9.0E-50 1.95Å Z02 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) RBL1 (P28749), CCNA2 (P20248) HUMAN 1H28_C 38.27 8.0E-50 2.8Å - 2003-02-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3S1H_A 38.27 9.0E-50 1.75Å 56Z 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1H1S_A 38.27 8.0E-50 2Å 4SP 2002-09-19
Protein kinase domain (99%) (view alignment) CDK1 (P06493) (K9J4F7) HUMAN 6GU7_G 37.46 3.0E-50 2.75Å - 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QQL_A 38.27 9.0E-50 1.85Å X03 2012-08-08
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5ICP_A 100 0 2.18Å 69Z 2016-12-21
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5FGK_A 100 0 2.36Å 5XG 2016-02-03
Protein kinase domain (99%) (view alignment) CDK2 (P24941) Ccna2 (P51943) HUMAN 4I3Z_A 38.27 9.0E-50 2.05Å ADP 2012-12-26
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 5NEV_A 38.27 8.0E-50 2.97Å 72L 2017-03-29
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4CFN_C 38.27 9.0E-50 2.2Å JYM 2013-12-18
Protein kinase domain (99%) (view alignment) CDK1 (P06493) (K9J4F7) HUMAN 6GU7_E 37.46 3.0E-50 2.75Å - 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R28_A 38.27 9.0E-50 1.75Å XA0 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RNI_A 38.27 9.0E-50 1.95Å 21Z 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2BPM_C 38.27 1.0E-49 2.4Å 529 2005-12-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1PKD_A 38.27 9.0E-50 2.3Å UCN 2003-06-24
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1E9H_C 38.27 9.0E-50 2.5Å INR 2001-10-11
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q3C_A 38.27 9.0E-50 1.29Å OCS 2019-03-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QZF_A 38.27 9.0E-50 2Å X66 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3PXF_A 38.27 9.0E-50 1.8Å 2AN 2011-02-16
Protein kinase domain (99%) (view alignment) CDK1 (P06493) CKS2 (P33552), CCNB1 (P14635) HUMAN 5LQF_A 37.46 3.0E-50 2.06Å 4SP 2017-01-11
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 4ERW_A 38.27 9.0E-50 2Å STU OCS 2012-08-22
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1H1P_A 38.27 8.0E-50 2.1Å CMG 2002-09-19
Protein kinase domain (99%) (view alignment) CDK1 (P06493) CCNB1 (P14635), (K9J4F7) HUMAN 6GU3_A 37.46 3.0E-50 2.65Å FB8 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) RBL1 (P28749), CCNA2 (P20248) HUMAN 1H28_A 38.27 8.0E-50 2.8Å - 2003-02-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QZH_A 38.27 9.0E-50 1.95Å X69 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 5IEY_A 38.27 1.0E-49 1.66Å 6AE 2016-04-27
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R83_A 38.27 9.0E-50 1.75Å Z14 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R9D_A 38.27 9.0E-50 1.95Å X6B 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R7Y_A 38.27 9.0E-50 1.9Å Z04 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4EOP_A 38.27 9.0E-50 1.99Å 1RO 2013-02-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RPV_A 38.27 9.0E-50 1.8Å 26Z 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P30274) HUMAN 6GUF_C 38.27 9.0E-50 2.65Å 23D 2018-12-05
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 4F6W_A 100 0 2.39Å 0SS 2013-05-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QX4_A 38.27 9.0E-50 1.92Å X4B 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1OI9_A 38.27 9.0E-50 2.1Å N20 2004-07-13
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QTU_A 38.27 9.0E-50 1.82Å X44 2012-10-31
Protein kinase domain (99%) (view alignment) CDK1 (P06493) (K9J4F7) HUMAN 6GU6_A 37.46 3.0E-50 2.33Å 1QK 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P30274) HUMAN 6GUE_A 38.27 1.0E-49 1.99Å FB8 2018-12-05
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 4G6L_A 100 0 2.7Å - 2013-05-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q4J_A 38.27 9.0E-50 1.05Å HHB 2019-03-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4EOQ_A 38.27 9.0E-50 2.15Å ATP 2013-02-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P30274) HUMAN 6GUB_A 38.27 9.0E-50 2.52Å F9Z 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QQH_A 38.27 9.0E-50 1.87Å X0A 2012-08-08
Protein kinase domain (99%) (view alignment) CDK1 (P06493) CKS2 (P33552), CCNB1 (P14635) HUMAN 5LQF_D 37.46 3.0E-50 2.06Å 4SP 2017-01-11
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R9O_A 38.27 9.0E-50 1.9Å Z71 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 5CYI_C 38.27 8.0E-50 2Å 55S 2015-09-16
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5HBE_A 100 0 2.38Å 5Y6 2016-02-03
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 5NEV_C 38.27 8.0E-50 2.97Å 72L 2017-03-29
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4CFV_C 38.27 8.0E-50 2Å 75X 2014-12-10
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QQF_A 38.27 9.0E-50 1.75Å X07 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2BPM_A 38.27 1.0E-49 2.4Å 529 2005-12-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R8V_A 38.27 9.0E-50 1.9Å Z62 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1H1R_C 38.27 8.0E-50 2Å 6CP 2002-09-19
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3S0O_A 38.27 9.0E-50 2Å 50Z 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) RB1 (P06400), CCNA2 (P20248) HUMAN 1H25_C 38.27 8.0E-50 2.5Å - 2003-02-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q4C_A 38.27 9.0E-50 1.73Å HH8 2019-03-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R8M_A 38.27 9.0E-50 1.8Å Z19 2012-08-08
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 3RGF_A 100 0 2.2Å BAX 2011-08-10
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4CFX_A 38.27 8.0E-50 2.95Å G6T 2014-12-10
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4CFM_A 38.27 8.0E-50 2.85Å 4QE 2014-12-10
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 4F7S_A 100 0 2.2Å 0SW 2013-05-01
Protein kinase domain (99%) (view alignment) CDK1 (P06493) CKS1B (P61024) HUMAN 4YC6_E 37.46 3.0E-50 2.6Å - 2015-05-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RZB_A 38.27 9.0E-50 1.9Å 02Z 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QRU_A 38.27 9.0E-50 1.95Å X19 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QTQ_A 38.27 9.0E-50 1.8Å X35 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4CFX_C 38.27 8.0E-50 2.95Å G6T 2014-12-10
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 4GCJ_A 38.27 9.0E-50 1.4Å X64 2012-10-31
Protein kinase domain (99%) (view alignment) CDK1 (P06493) (K9J4F7) HUMAN 6GU7_A 37.46 3.0E-50 2.75Å FB8 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R8P_A 38.27 9.0E-50 1.8Å Z46 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3S00_A 38.27 9.0E-50 1.8Å Z60 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R6X_A 38.27 9.0E-50 1.75Å X84 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RK7_A 38.27 9.0E-50 1.8Å 08Z 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QQJ_A 38.27 9.0E-50 1.7Å X11 2012-08-08
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 4F70_A 100 0 3Å 0ST 2013-05-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3PY1_A 38.27 9.0E-50 2.05Å 2AN SU9 2011-02-16
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 5IEV_A 38.27 1.0E-49 2.03Å R0N 2016-04-27
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5BNJ_A 100 0 2.64Å 4TV 2015-10-14
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RJC_A 38.27 9.0E-50 1.85Å 06Z 2012-10-31
Protein kinase domain (99%) (view alignment) CDK1 (P06493) CKS2 (P33552), CCNB1 (P14635) HUMAN 5HQ0_A 37.46 3.0E-50 2.3Å LZ9 2016-03-02
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q4D_A 38.27 9.0E-50 1.07Å HHT 2019-03-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RK9_A 38.27 9.0E-50 1.85Å 09Z 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4BCM_C 38.27 9.0E-50 2.39Å T7Z 2013-03-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2BKZ_C 38.27 1.0E-49 2.6Å SBC 2006-03-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R7I_A 38.27 9.0E-50 1.85Å X9I 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNE1 (P24864) HUMAN 1W98_A 38.27 9.0E-50 2.13Å - 2005-02-02
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4EOO_A 38.27 1.0E-49 2.1Å ATP 2013-02-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1PKD_C 38.27 9.0E-50 2.3Å UCN 2003-06-24
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5HVY_A 100 0 2.39Å 66X 2016-04-20
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5I5Z_A 100 0 2.6Å 68U 2016-04-13
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1OIU_A 38.27 9.0E-50 2Å N76 2004-07-13
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4EOR_A 38.27 9.0E-50 2.2Å 4SP 2013-02-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RPO_A 38.27 9.0E-50 1.75Å 24Z 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 4EZ3_A 38.27 9.0E-50 2Å 0S0 2012-08-22
Protein kinase domain (99%) (view alignment) CDK1 (P06493) CCNB1 (P14635), (K9J4F7) HUMAN 6GU2_A 37.46 3.0E-50 2Å F9Z 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1OIY_A 38.27 9.0E-50 2.4Å N41 2004-07-13
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4BCM_A 38.27 9.0E-50 2.39Å T7Z 2013-03-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QL8_A 38.27 9.0E-50 1.86Å X01 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 5IEX_A 38.27 1.0E-49 2.03Å 6AF 2016-04-27
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5XQX_A 100 0 2.3Å 8CC 2017-08-09
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R1S_A 38.27 9.0E-50 1.8Å X73 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 5CYI_A 38.27 8.0E-50 2Å 55S 2015-09-16
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3PXY_A 38.27 9.0E-50 1.8Å JWS 2011-02-16
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RPY_A 38.27 9.0E-50 1.9Å 27Z 2012-10-31
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5XS2_A 100 0 2.04Å 8D6 2017-08-09
Protein kinase domain (99%) (view alignment) CDK2 (P24941) E2F1 (Q01094), CCNA2 (P20248) HUMAN 1H24_A 38.27 8.0E-50 2.5Å - 2003-02-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1VYW_A 38.27 1.0E-49 2.3Å 292 2004-06-10
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1H1Q_C 38.27 8.0E-50 2.5Å 2A6 2002-09-19
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RKB_A 38.27 9.0E-50 2Å 12Z 2012-10-31
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 4F6S_A 100 0 2.6Å 0SQ 2013-05-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R8Z_A 38.27 9.0E-50 1.85Å Z63 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 5MHQ_A 38.27 9.0E-50 1.3Å 8QT 2017-12-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RK5_A 38.27 9.0E-50 2Å 07Z 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6GUH_A 38.27 9.0E-50 1.5Å FB8 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q49_A 38.27 9.0E-50 1Å HGQ 2019-03-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4CFV_A 38.27 8.0E-50 2Å 75X 2014-12-10
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P30274) HUMAN 6GUB_C 38.27 9.0E-50 2.52Å F9Z 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QZG_A 38.27 9.0E-50 1.75Å X67 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R1Y_A 38.27 9.0E-50 1.8Å X76 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3PY0_A 38.27 9.0E-50 1.75Å SU9 2011-02-16
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QTS_A 38.27 9.0E-50 1.9Å X46 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CDKN1B (P46527), CCNA2 (P20248) HUMAN 1H27_C 38.27 8.0E-50 2.2Å - 2003-02-01
Protein kinase domain (99%) (view alignment) CDK1 (P06493) CKS1B (P61024) HUMAN 4YC6_C 37.46 3.0E-50 2.6Å - 2015-05-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2WXV_A 38.27 1.0E-49 2.6Å WXV 2010-02-23
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1H1R_A 38.27 8.0E-50 2Å 6CP 2002-09-19
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P30274) HUMAN 6GUC_C 38.27 9.0E-50 2Å SU9 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 5LMK_C 38.27 9.0E-50 2.4Å 6ZK 2017-01-25
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q4A_A 38.27 9.0E-50 1.13Å HGW 2019-03-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1OI9_C 38.27 9.0E-50 2.1Å N20 2004-07-13
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2C4G_C 38.27 1.0E-49 2.7Å 514 2005-11-23
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q3B_A 38.27 9.0E-50 1.11Å - 2019-03-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) RB1 (P06400), CCNA2 (P20248) HUMAN 1H25_A 38.27 8.0E-50 2.5Å - 2003-02-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 5IF1_A 38.27 1.0E-49 2.61Å - 2016-04-27
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R8U_A 38.27 9.0E-50 2Å Z31 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1OGU_C 38.27 9.0E-50 2.6Å ST8 2003-09-02
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4EOS_C 38.27 9.0E-50 2.57Å 1RO 2013-02-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q4E_A 38.27 9.0E-50 1.06Å HH5 2019-03-20
Protein kinase domain (99%) (view alignment) CDK1 (P06493) (K9J4F7) HUMAN 6GU7_C 37.46 3.0E-50 2.75Å - 2018-12-05
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) 2WMB_A 38.27 8.0E-50 2.5Å - 2010-09-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2WIP_A 38.27 1.0E-49 2.8Å P49 2009-07-28
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) 2WMA_A 38.27 8.0E-50 2.8Å - 2010-09-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 5JQ5_A 38.27 1.0E-49 1.94Å I74 2017-02-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QQK_A 38.27 9.0E-50 1.85Å X02 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3QTR_A 38.27 9.0E-50 1.85Å X36 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RPR_A 38.27 9.0E-50 1.7Å 25Z 2012-10-31
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5CEI_A 100 0 2.24Å 50R 2016-02-10
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RAL_A 38.27 9.0E-50 1.75Å 04Z 2012-10-31
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2BKZ_A 38.27 1.0E-49 2.6Å SBC 2006-03-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RM7_A 38.27 9.0E-50 1.8Å 19Z 2012-08-08
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 4F7N_A 100 0 2.65Å 0SV 2013-05-01
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1H1Q_A 38.27 8.0E-50 2.5Å 2A6 2002-09-19
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2C4G_A 38.27 1.0E-49 2.7Å 514 2005-11-23
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4EOQ_C 38.27 9.0E-50 2.15Å ATP 2013-02-06
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3R1Q_A 38.27 9.0E-50 1.85Å X75 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 1VYW_C 38.27 1.0E-49 2.3Å 292 2004-06-10
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 3RAI_A 38.27 9.0E-50 1.7Å X85 2012-08-08
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4CFU_A 38.27 8.0E-50 2.2Å 2WC 2014-12-10
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 6Q4G_A 38.27 9.0E-50 0.98Å HJK 2019-03-20
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4CFU_C 38.27 8.0E-50 2.2Å 2WC 2014-12-10
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 2WIH_A 38.27 1.0E-49 2.5Å P48 2009-07-28
Protein kinase domain (99%) (view alignment) CDK2 (P24941) - HUMAN 5OO0_A 38.27 8.0E-50 1.6Å 9YZ 2018-03-14
Protein kinase domain (99%) (view alignment) CDK2 (P24941) CCNA2 (P20248) HUMAN 4CFM_C 38.27 8.0E-50 2.85Å 4QE 2014-12-10
Protein kinase domain (100%) (view alignment) CDK8 (P49336) CCNC (P24863) HUMAN 5HBH_A 100 0 2.5Å 5Y7 2016-02-03