Molecular Target Synopsis
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CDK8 (P49336) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed25
Chains with at least one site assessed as druggable using the strict criteria24
Chains with at least one site assessed as druggable using the relaxed criteria25


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4CRL_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 71.3 38.2 Yes Yes
2 empty 1.74 67.6 23.7 No No
3 empty 2.24 57.4 24.1 No No
4 empty 2.19 55 21.3 No No
5 bound 2.02 70.1 16.3 No No
6 empty 1.63 66.3 18.6 No No
7 empty 1.99 56.9 22.3 No No
8 empty 1.85 65.6 15.3 No No
9 empty 1.63 65.3 14.3 No No
10 bound 2.04 69.3 10.6 No No
4F6U_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 68.6 27 Yes Yes
2 empty 2.05 61.5 26.2 No No
3 empty 1.8 65.8 19.5 No No
4 empty 1.88 63.6 22.7 No No
5 bound 1.76 75.7 19.7 No No
6 empty 2.08 66.2 15.1 No No
7 empty 2.08 69.7 15.1 No No
8 empty 2.01 64.5 13.3 No No
9 bound 2.47 61 15.7 No No
10 empty 2.27 61.1 20.9 No No
4F7J_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 75.3 40.9 Yes Yes
2 bound 2.3 66.2 42.9 No No
3 empty 2.03 63 29.4 No No
4 empty 2.21 65.6 23.4 No No
5 empty 1.91 69.4 20.4 No No
6 empty 2.01 65.6 19.8 No No
7 empty 2.32 68 22.8 No No
8 empty 1.79 69.6 15 No No
9 empty 2.48 65.7 11.4 No No
10 empty 2.37 69.2 10.2 No No
5HBJ_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 76.3 39.1 Yes Yes
2 empty 2.32 66.5 29.8 No No
3 empty 1.92 62.2 28.7 No No
4 empty 2.34 67.4 25.1 No No
5 empty 2.34 64.7 24.9 No No
6 empty 1.76 69.8 20.2 No No
7 bound 1.77 66.8 26.9 No No
8 empty 1.94 62.6 19.7 No No
9 empty 2.03 57.5 16.7 No No
10 empty 2.57 68.5 13.3 No No
5IDN_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 70.2 47.4 Yes Yes
2 empty 2.03 61.6 26.6 No No
3 empty 1.8 68.2 16.6 No No
4 bound 2.33 59.4 20.1 No No
5 empty 2.25 58.4 24.1 No No
6 empty 2.11 66.8 17.6 No No
7 empty 1.89 60 15.4 No No
8 empty 1.93 45.6 15 No No
9 bound 1.78 67.8 13.1 No No
10 empty 2.21 57.9 14.4 No No
4F7L_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 75.9 42.7 Yes Yes
2 empty 2.58 64.9 41.8 No No
3 empty 2.26 67.8 25.1 No No
4 empty 2.17 66.9 29.8 No No
5 empty 1.74 69.2 22.5 No No
6 empty 2.04 63.5 18.2 No No
7 empty 2.5 67.1 14.6 No No
8 empty 1.55 69.3 18.5 No No
9 empty 2.54 70.1 12.5 No No
10 empty 2.26 74.7 9.4 No No
5IDP_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 69.7 42.4 Yes Yes
2 empty 2.19 64 35 No No
3 empty 1.88 62.3 22.1 No No
4 empty 2.15 65.1 20 No No
5 empty 2.2 64.1 20 No No
6 empty 1.78 64.3 20.8 No No
7 empty 2.23 69.6 14.6 No No
8 bound 2.37 59.9 18.3 No No
9 empty 1.86 59.5 15.3 No No
10 empty 2.51 64.7 11 No No
5HNB_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 75.2 33.3 Yes Yes
2 bound 2.24 59.7 34.7 No No
3 empty 2.19 59.2 25 No No
4 empty 2.02 65.7 23.7 No No
5 empty 2.29 64.7 22.9 No No
6 bound 2.29 58.8 28.2 No No
7 empty 1.86 67.5 16.9 No No
8 empty 1.79 61.9 16 No No
9 empty 1.58 58.2 11.6 No No
10 empty 2.39 61.7 11.7 No No
5ICP_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 71.9 39.9 Yes Yes
2 empty 2.01 65.6 26.6 No No
3 empty 1.92 64.7 21.8 No No
4 empty 1.99 62 27.1 No No
5 bound 2.29 56.9 26.8 No No
6 empty 2.11 68.5 17.7 No No
7 empty 2.21 49.8 18.2 No No
8 empty 2.03 46.6 16.9 No No
9 empty 1.84 57.7 16.2 No No
10 empty 1.85 57.5 15.6 No No
5FGK_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 72.1 36.1 Yes Yes
2 empty 2.09 62.9 22.6 No No
3 empty 2.09 60.6 27.8 No No
4 empty 1.87 65.8 24.6 No No
5 empty 2.1 66.6 16.9 No No
6 empty 2.23 76.4 15.4 No No
7 empty 2.45 60.2 16.7 No No
8 bound 2.08 61.1 17.9 No No
9 bound 1.63 61.4 21.7 No No
10 bound 2.32 60.8 14.4 No No
4F6W_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 71.1 39.6 Yes Yes
2 empty 1.8 62.3 23.9 No No
3 bound 1.98 76.1 20.4 No No
4 empty 1.89 64.1 25 No No
5 bound 2.26 57 27.7 No No
6 empty 2.23 54.1 20.6 No No
7 empty 2.12 66.5 17.1 No No
8 empty 1.83 65.8 15 No No
9 bound 1.88 63.5 22.9 No No
10 empty 2 56.2 15 No No
4G6L_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 75.5 35.4 Yes Yes
2 empty 2.33 64.3 31.4 No No
3 empty 1.71 67.1 33.5 No No
4 empty 2.26 69.2 25.7 No No
5 empty 1.83 70.7 22.5 No No
6 empty 2.39 64 23.8 No No
7 empty 2.19 62.8 16.4 No No
8 empty 1.95 67.1 15.6 No No
9 empty 1.71 69.1 20.1 No No
10 empty 1.87 76.8 11 No No
5HBE_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 75.4 34.9 Yes Yes
2 bound 2.26 63.6 28.7 No No
3 empty 1.89 62.9 27.8 No No
4 empty 1.77 67.5 16.7 No No
5 empty 2.06 67.6 19.5 No No
6 bound 2.27 61.7 24.3 No No
7 empty 2.25 53.6 20.2 No No
8 empty 1.83 65.3 15.7 No No
9 empty 2.16 61.1 12.8 No No
10 empty 1.89 56.1 15.9 No No
3RGF_A Cyclin-dependent kinase 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 64.8 36 Yes No
2 empty 1.92 62 24.3 No No
3 empty 2.05 58.3 19.9 No No
4 bound 2.34 56.3 26.3 No No
5 bound 1.98 70.4 17.2 No No
6 bound 2.08 65.5 14.2 No No
7 bound 1.72 65.6 14.4 No No
8 empty 2.24 70.8 13.2 No No
9 empty 2.09 62.9 15.2 No No
10 empty 2.39 58.1 12.6 No No
4F7S_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 73 40.7 Yes Yes
2 bound 2.14 64.3 28.9 No No
3 empty 2.03 61.5 27.6 No No
4 empty 1.93 66.8 19.5 No No
5 bound 2.39 57.4 27.4 No No
6 empty 2.49 72.9 15.3 No No
7 empty 2.15 55.8 19.8 No No
8 empty 1.88 61.9 18.5 No No
9 empty 2.23 56 12.6 No No
10 empty 1.96 63.4 14.3 No No
4F70_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 78.1 38.2 Yes Yes
2 empty 2 62.4 36.1 No No
3 empty 2.26 66.5 23.9 No No
4 empty 2.32 68.8 21 No No
5 empty 2.27 60.6 27.8 No No
6 empty 1.87 70.1 16.3 No No
7 empty 1.93 66.2 17.8 No No
8 empty 2.16 60.4 14.9 No No
9 empty 2.68 60.8 15.8 No No
10 empty 1.32 74.3 11.8 No No
5BNJ_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 78 33.8 Yes Yes
2 empty 1.75 65.2 34.9 No No
3 empty 2.28 67.4 23 No No
4 empty 2.24 74.5 27.3 No No
5 empty 1.84 60.3 32.3 No No
6 empty 1.97 69 23 No No
7 empty 2.2 68.7 22.4 No No
8 empty 2.13 60.2 22 No No
9 empty 2.17 66.5 10.7 No No
10 empty 2.59 69.2 21.8 No No
5HVY_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 71.8 45.4 Yes Yes
2 empty 2.12 64 33.8 No No
3 empty 2.28 66.4 22.3 No No
4 empty 1.92 70 21.8 No No
5 empty 2.17 66.6 26.9 No No
6 empty 1.33 68 18.4 No No
7 empty 1.89 66.8 14.1 No No
8 empty 1.9 98.6 0 Yes No
9 empty 1.58 72 9.8 No No
10 empty 2.16 74.7 10.1 No No
5I5Z_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 75.4 26.9 Yes Yes
2 empty 2.01 67 27.9 No No
3 bound 2.18 61.4 27.1 No No
4 empty 1.89 61.7 29.5 No No
5 empty 2.13 59.6 19.9 No No
6 empty 1.66 67.9 23 No No
7 empty 2.16 68.9 15.7 No No
8 empty 1.85 62.1 15.4 No No
9 empty 2.55 50.9 12.7 No No
10 empty 2.37 63.3 12.7 No No
5XQX_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 71.2 51.5 Yes Yes
2 empty 2.39 66.6 30 No No
3 empty 2.3 63.4 33.7 No No
4 empty 2.4 69.2 22.6 No No
5 empty 2.45 62.1 17.8 No No
6 bound 2.18 64.4 20.6 No No
7 empty 2.26 65.4 18 No No
8 empty 1.33 70.2 16.9 No No
9 empty 2.22 62.9 14.7 No No
10 empty 2.09 74.5 12.7 No No
5XS2_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 72.3 30.4 Yes Yes
2 empty 1.76 66.8 24.2 No No
3 empty 1.98 74.1 20.6 No No
4 empty 1.87 60.6 20.4 No No
5 empty 2.12 67.9 16.2 No No
6 empty 1.99 67.7 20.3 No No
7 empty 1.48 57.1 29.3 No No
8 empty 2.06 63.3 14.5 No No
9 empty 2.2 59.1 15.6 No No
10 empty 2.32 54.5 14.2 No No
4F6S_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 73.6 23.4 Yes Yes
2 bound 1.96 77.3 23 No No
3 empty 1.84 59.8 24 No No
4 empty 1.88 65.8 22 No No
5 empty 1.75 67.1 23.8 No No
6 empty 2.17 59.8 20.2 No No
7 empty 2.27 70.2 18.7 No No
8 bound 2.49 61.6 16.6 No No
9 empty 2.3 61.8 14.3 No No
10 empty 2.3 54.2 13.4 No No
5CEI_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 72.4 36.5 Yes Yes
2 bound 2.24 60.7 29.3 No No
3 empty 1.9 66.4 24.9 No No
4 bound 2.38 56 28 No No
5 empty 1.99 63.1 24.3 No No
6 empty 2.24 66.6 17.3 No No
7 empty 2.28 54.8 20.8 No No
8 empty 2.26 53.1 13.4 No No
9 empty 2.02 63.2 14.2 No No
10 empty 1.69 62.5 13.1 No No
4F7N_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 71.7 24.1 Yes Yes
2 empty 1.83 60.4 21.8 No No
3 empty 2.23 69.2 22.4 No No
4 empty 1.92 67.9 16.1 No No
5 empty 2 63.4 26.8 No No
6 bound 1.81 84.6 18.1 Yes No
7 bound 2.4 61.4 15.9 No No
8 empty 1.9 64 15.9 No No
9 empty 2.23 61.6 15.3 No No
10 empty 1.99 65.8 13.8 No No
5HBH_A Cyclin-dependent kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 74.2 42.9 Yes Yes
2 empty 2.5 61.5 37.6 No No
3 empty 1.89 66.7 26 No No
4 empty 2.38 70.4 25.5 No No
5 bound 1.86 69.5 13.8 No No
6 empty 2.4 61.3 23.6 No No
7 empty 2.21 71.6 19.1 No No
8 empty 1.33 73.7 11.4 No No
9 empty 2.26 59.3 14.5 No No
10 empty 2.36 66.3 9.7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed1
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria1

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3RGF_A (3700004) Cyclin-dependent kinase 8 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.2Å Yes No
Ligand-based Druggability Score: -0.3
Ligand-based Druggability Score Percentile: 76%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


CDK8 is involved in 32 interactions in the network.


Druggability
Overall Druggability Percentile: 78.43
Druggability for Cancer Therapeutics: 94.53
Druggability for Other Therapeutics: 36.55
Cancer-Associated
Cancer-associated percentile : 94.63
Network Articulation Point
Is CDK8 critical for communication in the network?


Detailed Graph Legend:Help