Molecular Target Synopsis
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FASN (P49327) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%) (view alignment) Fasn (P19096) - MOUSE 5MY2_C 87.07 0 2.7Å - 2018-02-21
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5E6K_B 35.53 5.0E-68 2.16Å - 2015-11-18
Zinc-binding dehydrogenase (100%) (view alignment) FASN (P49327) - HUMAN 4W82_B 100 0 1.7Å - 2014-10-15
Phosphopantetheine attachment site (100%) (view alignment) Fasn (P12785) - NORWAY RAT 2PNG_A 77.01 3.0E-22 - 2007-06-05
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%) (view alignment) Fasn (P19096) - MOUSE 5MY2_A 87.07 0 2.7Å - 2018-02-21
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%) (view alignment) Fasn (P19096) - MOUSE 5MY2_D 87.07 0 2.7Å COA 2018-02-21
Zinc-binding dehydrogenase (100%) (view alignment) FASN (P49327) - HUMAN 4W9N_B 100 0 1.84Å TCL 2014-10-15
Ketoacyl-synthetase C-terminal extension (46%), Acyl transferase domain (100%) (view alignment) FASN (P49327) - HUMAN 2JFD_D 100 0 2.8Å - 2007-02-13
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5E5N_B 35.53 5.0E-68 2Å - 2015-11-18
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%), Polyketide synthase dehydratase (41%) (view alignment) FASN (P49327) - HUMAN 3HHD_D 100 0 2.15Å - 2010-02-09
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5E5N_C 35.53 5.0E-68 2Å - 2015-11-18
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksJ (P40806) - 4NA2_B 35.71 1.0E-68 2.3Å 2JF 2014-02-19
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5E6K_A 35.53 5.0E-68 2.16Å - 2015-11-18
Thioesterase domain (100%) (view alignment) FASN (P49327) - HUMAN 2PX6_B 100 0 2.3Å DH9 2007-07-10
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5ERF_A 35.76 4.0E-69 3.1Å - 2015-12-23
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%), Acyl transferase domain (100%) (view alignment) eryA (Q03132) - 2QO3_A 37.47 1.0E-17 2.59Å CER 2007-09-04
Polyketide synthase dehydratase (100%), Zinc-binding dehydrogenase (100%), KR domain (100%) (view alignment) (Q9VQL7) - FRUIT FLY 6FN6_B 53.79 2.0E-55 2.7Å - 2019-03-13
Zinc-binding dehydrogenase (100%) (view alignment) FASN (P49327) - HUMAN 4W82_A 100 0 1.7Å - 2014-10-15
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%), Polyketide synthase dehydratase (100%), Methyltransferase domain (100%), Zinc-binding dehydrogenase (100%), KR domain (100%), Phosphopantetheine attachment site (100%), Thioesterase domain (100%) (view alignment) (A5YV76) - PIG 2VZ9_B 78.68 0 3.2Å NAP 2008-09-09
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5E5N_A 35.53 5.0E-68 2Å - 2015-11-18
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%), Polyketide synthase dehydratase (41%) (view alignment) FASN (P49327) - HUMAN 3HHD_B 100 0 2.15Å - 2010-02-09
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksJ (P40806) - 4NA2_A 35.71 1.0E-68 2.3Å 2JF 2014-02-19
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5E5N_D 35.53 5.0E-68 2Å - 2015-11-18
Ketoacyl-synthetase C-terminal extension (46%), Acyl transferase domain (100%) (view alignment) FASN (P49327) - HUMAN 2JFK_B 100 0 2.4Å COA MCS 2007-03-13
Thioesterase domain (100%) (view alignment) FASN (P49327) - HUMAN 2PX6_A 100 0 2.3Å DH9 2007-07-10
Ketoacyl-synthetase C-terminal extension (46%), Acyl transferase domain (100%) (view alignment) FASN (P49327) - HUMAN 2JFK_A 100 0 2.4Å COA MCS 2007-03-13
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%), Acyl transferase domain (100%) (view alignment) eryA (Q03132) - 2QO3_B 37.47 1.0E-17 2.59Å CER 2007-09-04
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5ENY_G 35.76 1.0E-69 4Å - 2015-12-23
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%) (view alignment) Fasn (P19096) - MOUSE 5MY0_D 87.07 0 2.9Å COA K5L 2018-01-24
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) (Q1RS72) - 5ERB_D 38.95 2.0E-76 4.2Å - 2015-12-23
Zinc-binding dehydrogenase (100%) (view alignment) ppsC (P96202) - 1PQW_A 39.3 3.0E-32 2.65Å - 2003-07-08
Thioesterase domain (100%) (view alignment) FASN (P49327) - HUMAN 3TJM_A 100 0 1.48Å 7FA 2011-09-28
Ketoacyl-synthetase C-terminal extension (46%), Acyl transferase domain (100%) (view alignment) FASN (P49327) - HUMAN 2JFK_C 100 0 2.4Å COA MCS 2007-03-13
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) (D0U2E4) - 4TKT_A 36.32 4.0E-61 2.429Å MES 2014-06-11
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) (B2WW42) - 4OPE_B 38.48 1.0E-67 2.58Å - 2014-02-19
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) (D0U2E4) - 4ZDN_A 37.21 8.0E-69 2.509Å EPE 2015-05-13
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%), Polyketide synthase dehydratase (41%) (view alignment) FASN (P49327) - HUMAN 3HHD_A 100 0 2.15Å - 2010-02-09
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) (Q1RS72) - 5ERB_C 38.95 2.0E-76 4.2Å - 2015-12-23
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksJ (P40806) - 4NA1_A 35.94 6.0E-70 1.9Å - 2014-02-19
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksJ (P40806) - 4NA3_B 35.71 1.0E-68 2.83Å 2JG 2014-02-19
Zinc-binding dehydrogenase (100%) (view alignment) FASN (P49327) - HUMAN 4W9N_D 100 0 1.84Å TCL 2014-10-15
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksJ (P40806) - 4NA1_B 35.94 6.0E-70 1.9Å - 2014-02-19
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5ENY_H 35.76 1.0E-69 4Å - 2015-12-23
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) (B2WW42) - 4OPE_C 38.48 1.0E-67 2.58Å - 2014-02-19
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%), Polyketide synthase dehydratase (41%) (view alignment) FASN (P49327) - HUMAN 3HHD_C 100 0 2.15Å - 2010-02-09
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) (B2WW42) - 4OPE_A 38.48 1.0E-67 2.58Å - 2014-02-19
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5ENY_C 35.76 1.0E-69 4Å - 2015-12-23
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%) (view alignment) Fasn (P19096) - MOUSE 5MY0_B 87.07 0 2.9Å - 2018-01-24
Zinc-binding dehydrogenase (100%) (view alignment) FASN (P49327) - HUMAN 4W9N_A 100 0 1.84Å - 2014-10-15
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5ENY_A 35.76 1.0E-69 4Å - 2015-12-23
Zinc-binding dehydrogenase (100%) (view alignment) ppsC (P96202) - 4OKI_B 39.29 3.0E-31 1.4Å - 2015-08-05
Thioesterase domain (100%) (view alignment) FASN (P49327) - HUMAN 4Z49_B 100 0 1.7Å - 2016-03-16
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) (Q1RS72) - 5ERB_A 38.95 2.0E-76 4.2Å - 2015-12-23
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) (B2WW42) - 4OPE_D 38.48 1.0E-67 2.58Å - 2014-02-19
Polyketide synthase dehydratase (100%), Zinc-binding dehydrogenase (100%), KR domain (100%) (view alignment) (Q9VQL7) - FRUIT FLY 6FN6_A 53.79 2.0E-55 2.7Å - 2019-03-13
Thioesterase domain (100%) (view alignment) FASN (P49327) - HUMAN 4Z49_A 100 0 1.7Å - 2016-03-16
Zinc-binding dehydrogenase (100%) (view alignment) ppsC (P96202) - 1PQW_B 39.3 3.0E-32 2.65Å - 2003-07-08
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5ERF_B 35.76 4.0E-69 3.1Å - 2015-12-23
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%) (view alignment) Fasn (P19096) - MOUSE 5MY0_C 87.07 0 2.9Å MLC 2018-01-24
Methyltransferase domain (100%), Zinc-binding dehydrogenase (100%), KR domain (100%) (view alignment) FASN (P49327) - HUMAN 6NNA_A 100 0 2.26Å KUA CAF NDP 2019-02-20
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) (C0ZGQ5) - 4Z37_A 35.47 2.0E-64 1.998Å - 2016-04-13
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%), Polyketide synthase dehydratase (100%), Methyltransferase domain (100%), Zinc-binding dehydrogenase (100%), KR domain (100%), Phosphopantetheine attachment site (100%), Thioesterase domain (100%) (view alignment) (A5YV76) - PIG 2VZ9_A 78.68 0 3.2Å NAP 2008-09-09
Ketoacyl-synthetase C-terminal extension (46%), Acyl transferase domain (100%) (view alignment) FASN (P49327) - HUMAN 2JFK_D 100 0 2.4Å COA MCS 2007-03-13
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5ENY_F 35.76 1.0E-69 4Å - 2015-12-23
Ketoacyl-synthetase C-terminal extension (46%), Acyl transferase domain (100%) (view alignment) FASN (P49327) - HUMAN 2JFD_B 100 0 2.8Å - 2007-02-13
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5ENY_B 35.76 1.0E-69 4Å - 2015-12-23
Thioesterase domain (100%) (view alignment) FASN (P49327) - HUMAN 1XKT_B 100 0 2.6Å - 2004-10-26
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%), Polyketide synthase dehydratase (100%), Methyltransferase domain (100%), Zinc-binding dehydrogenase (100%), KR domain (100%), Phosphopantetheine attachment site (100%), Thioesterase domain (100%) (view alignment) (A5YV76) - PIG 2VZ8_A 78.68 0 3.2Å - 2008-09-09
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%) (view alignment) Fasn (P19096) - MOUSE 5MY0_A 87.07 0 2.9Å COA K5L 2018-01-24
Methyltransferase domain (100%), Zinc-binding dehydrogenase (100%), KR domain (100%) (view alignment) FASN (P49327) - HUMAN 6NNA_B 100 0 2.26Å KUA CAF NDP 2019-02-20
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) (D0U2E3) - 4QYR_A 38.76 5.0E-77 2.9Å - 2014-08-20
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%) (view alignment) Fasn (P19096) - MOUSE 5MY2_B 87.07 0 2.7Å - 2018-02-21
Ketoacyl-synthetase C-terminal extension (46%), Acyl transferase domain (100%) (view alignment) FASN (P49327) - HUMAN 2JFD_A 100 0 2.8Å - 2007-02-13
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksJ (P40806) - 4NA3_A 35.71 1.0E-68 2.83Å 2JG 2014-02-19
Polyketide synthase dehydratase (1%), Methyltransferase domain (100%), KR domain (100%) (view alignment) FASN (P49327) - HUMAN 5C37_A 100 0 2.3Å NDP 4XN 2016-06-22
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5ENY_E 35.76 1.0E-69 4Å - 2015-12-23
Methyltransferase domain (100%), Zinc-binding dehydrogenase (100%), KR domain (100%) (view alignment) FASN (P49327) - HUMAN 4PIV_A 100 0 2.227Å 2W4 NDP 2014-07-23
Polyketide synthase dehydratase (1%), Methyltransferase domain (100%), KR domain (100%) (view alignment) FASN (P49327) - HUMAN 5C37_C 100 0 2.3Å NDP 4XN 2016-06-22
Thioesterase domain (100%) (view alignment) FASN (P49327) - HUMAN 1XKT_A 100 0 2.6Å - 2004-10-26
Methyltransferase domain (100%), Zinc-binding dehydrogenase (100%), KR domain (100%) (view alignment) FASN (P49327) - HUMAN 4PIV_B 100 0 2.227Å 2W4 NDP 2014-07-23
Beta-ketoacyl synthase, N-terminal domain (99%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) pksL (Q05470) - 5ENY_D 35.76 1.0E-69 4Å - 2015-12-23
Zinc-binding dehydrogenase (100%) (view alignment) ppsC (P96202) - 4OKI_A 39.29 3.0E-31 1.4Å - 2015-08-05
Zinc-binding dehydrogenase (100%) (view alignment) FASN (P49327) - HUMAN 4W9N_C 100 0 1.84Å CCS 2014-10-15
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (38%) (view alignment) (Q1RS72) - 5ERB_B 38.95 2.0E-76 4.2Å - 2015-12-23
Ketoacyl-synthetase C-terminal extension (46%), Acyl transferase domain (100%) (view alignment) FASN (P49327) - HUMAN 2JFD_C 100 0 2.8Å - 2007-02-13
Phosphopantetheine attachment site (100%) (view alignment) FASN (P49327) AASDHPPT (Q9NRN7) HUMAN 2CG5_B 100 0 2.7Å - 2006-03-01
Beta-ketoacyl synthase, N-terminal domain (100%), Beta-ketoacyl synthase, C-terminal domain (100%), Ketoacyl-synthetase C-terminal extension (100%), Acyl transferase domain (100%), Polyketide synthase dehydratase (100%), Methyltransferase domain (100%), Zinc-binding dehydrogenase (100%), KR domain (100%), Phosphopantetheine attachment site (100%), Thioesterase domain (100%) (view alignment) (A5YV76) - PIG 2VZ8_B 78.68 0 3.2Å - 2008-09-09