Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FASN (P49327) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed32
Chains with at least one site assessed as druggable using the strict criteria27
Chains with at least one site assessed as druggable using the relaxed criteria31


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4W9N_B Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 67.7 42.4 Yes Yes
2 bound 1.58 81.9 26.4 Yes Yes
3 empty 1.97 67.9 27.5 No No
4 empty 2.11 63.4 23.7 No No
5 empty 2.07 56.7 16.9 No No
6 empty 2.26 60.5 18.1 No No
7 bound 1.72 66.8 14.1 No No
8 empty 1.96 61.3 13.3 No No
9 empty 1.83 69.4 12.2 No No
10 empty 1.8 61.4 15.5 No No
3HHD_D Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 66.3 52.8 Yes Yes
2 empty 1.63 73.7 31.9 Yes No
3 empty 2.27 69 29.3 No No
4 empty 2.23 68.9 36.2 No No
5 empty 2.09 63.7 23.9 No No
6 empty 1.45 79 19 No No
7 empty 2.3 59.9 25.7 No No
8 empty 2.56 66.7 29.9 No No
9 empty 2.12 67.5 16.6 No No
10 empty 2.3 67.5 26.5 No No
2PX6_B Fatty acid synthase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 65.3 26.1 Yes No
2 bound 1.86 68.7 26.3 No No
3 empty 2.34 69.8 26.3 No No
4 empty 2.33 60.3 19.5 No No
5 empty 2.38 65.4 14.1 No No
6 empty 1.94 66.3 13.1 No No
7 empty 2.75 60.8 20.6 No No
8 empty 2.44 58.8 11.2 No No
9 bound 1.72 63.5 14.1 No No
10 empty 2.18 70 13.6 No No
4W82_A Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.44 70.9 33.9 Yes Yes
2 empty 1.89 67.5 26 No No
3 empty 2.32 61.6 24.3 No No
4 empty 2.48 63.4 23.6 No No
5 empty 1.87 68.2 15.4 No No
6 empty 2.15 57.1 16.6 No No
7 empty 2.03 66.1 11.3 No No
8 empty 1.89 66.7 11.1 No No
9 empty 2.58 54.2 17.8 No No
10 empty 2.25 62.3 14.1 No No
2JFK_B Fatty acid synthase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 69.4 46.9 Yes No
2 empty 1.98 65.1 21.4 No No
3 empty 2.23 71.8 14.2 No No
4 empty 2.07 70.4 13.1 No No
5 empty 2.06 72.5 11.5 No No
6 empty 1.63 62.2 11.7 No No
7 empty 2.11 70.2 9 No No
8 empty 1.72 59.4 16.6 No No
9 empty 1.93 75.9 7.8 No No
10 empty 2.3 62.9 13.9 No No
2PX6_A Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 69.3 40.3 Yes Yes
2 empty 2.22 67.3 38.4 No No
3 empty 2.46 59.7 13.6 No No
4 empty 2.4 67.1 12.6 No No
5 empty 2.09 70.2 7.7 No No
6 empty 2.35 73.7 10.9 No No
7 empty 2.09 58.1 12.6 No No
8 empty 2.4 50.2 10.7 No No
9 empty 2.26 66.3 7.4 No No
10 empty 2.09 52.4 7.5 No No
3HHD_A Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.58 73.8 39.9 Yes Yes
2 empty 2.38 65 31.1 No No
3 empty 2.38 64.9 38.9 No No
4 empty 2.31 70.5 24 No No
5 empty 2.12 65 25.9 No No
6 empty 2.11 59.6 27.1 No No
7 empty 1.44 79.1 18.2 No No
8 empty 2.08 70.9 14.3 No No
9 empty 2.04 67.7 26.2 No No
10 empty 2.22 66.7 20.5 No No
4W9N_D Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 76.5 29.7 Yes Yes
2 empty 1.94 65.9 35.7 No No
3 empty 2.46 64.4 23.3 No No
4 empty 1.91 67.5 12 No No
5 empty 2.07 59.7 13.5 No No
6 empty 2.11 67.1 15.1 No No
7 bound 1.87 63.8 12 No No
8 empty 2.07 56.5 12.1 No No
9 empty 2.22 69.1 8.8 No No
10 empty 1.67 69 9.9 No No
4Z49_B Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 66.8 31.3 Yes Yes
2 empty 1.99 67.1 42.3 No No
3 empty 2.33 65.8 29.1 No No
4 empty 2.27 73.1 21.9 No No
5 empty 2.28 61.9 17.9 No No
6 empty 2.09 71.1 8.8 No No
7 empty 2.19 64.9 13.2 No No
8 empty 2.42 68.6 13 No No
9 empty 2.06 65.2 13 No No
10 empty 2.47 75.6 7.8 No No
2JFK_D Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 69.9 46.7 Yes Yes
2 empty 2.12 65.1 40.7 No No
3 empty 2.09 66.1 24.9 No No
4 empty 2.18 69.4 15.4 No No
5 empty 2.05 62.4 17.4 No No
6 empty 1.61 63.6 17.9 No No
7 empty 1.81 63.6 13.6 No No
8 empty 2.22 64.9 13.7 No No
9 empty 1.9 64.1 13.7 No No
10 empty 1.87 76.8 13.9 No No
2JFD_B Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 75.8 35.8 Yes Yes
2 empty 2.32 67.6 36.1 No No
3 empty 2.02 63.9 24.5 No No
4 empty 1.9 69.6 17 No No
5 empty 1.62 65.8 12.8 No No
6 empty 1.72 66.5 15.1 No No
7 empty 1.96 74.4 11.5 No No
8 empty 2.26 71.7 9.4 No No
9 empty 1.99 62.7 13.6 No No
10 empty 1.91 68.9 9.1 No No
1XKT_B Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 67.7 39.6 Yes Yes
2 empty 2.03 63.6 17.5 No No
3 empty 2.4 63.1 12.9 No No
4 empty 2.08 66.6 13.3 No No
5 empty 2.46 70.8 14.7 No No
6 empty 2.32 60.1 15.6 No No
7 empty 2.06 65 16.1 No No
8 empty 2.25 55.4 15.7 No No
9 empty 2.41 69.8 12 No No
10 empty 2.29 59 17.3 No No
6NNA_B Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 72.7 26.8 Yes Yes
2 bound 1.7 65 22.3 No No
3 bound 2.21 70.6 26.7 No No
4 empty 2.19 59.4 19.6 No No
5 empty 1.92 68.1 24.7 No No
6 empty 2.14 60.1 32 No No
7 empty 2.15 80.7 20.4 No No
8 empty 2.03 72.1 17.7 No No
9 empty 2.06 60.5 23.6 No No
10 empty 2.11 66.3 15.1 No No
2JFD_A Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 73.6 41.5 Yes Yes
2 empty 2.1 68.1 31.1 No No
3 empty 2.32 68.7 19.2 No No
4 empty 2.06 66.1 26.7 No No
5 empty 2.13 65.6 19.7 No No
6 empty 1.56 64.5 14.5 No No
7 empty 2 71.3 14.5 No No
8 empty 2.31 69.1 14.4 No No
9 empty 2.21 68.5 12.2 No No
10 empty 1.94 60.7 9.8 No No
5C37_C Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 77.2 30.3 Yes Yes
2 empty 1.94 65.4 28.9 No No
3 empty 1.78 66.2 21.9 No No
4 bound 1.81 62.1 22.7 No No
5 empty 2.12 59.4 19 No No
6 empty 2.06 59 26.9 No No
7 empty 2.06 58.6 19.8 No No
8 bound 1.75 96.1 0 Yes No
9 empty 2.07 77.2 12.9 No No
10 empty 1.81 71.8 13.3 No No
4PIV_B Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 75.9 26.8 Yes Yes
2 empty 1.66 63.7 21.8 No No
3 empty 2.01 68 22.4 No No
4 empty 2.16 70.1 17.2 No No
5 bound 1.88 61.7 23.7 No No
6 empty 1.84 57.3 20.9 No No
7 empty 1.9 95.5 0 Yes No
8 empty 1.85 61.9 17.8 No No
9 empty 1.9 66.1 17.9 No No
10 empty 2.2 62.7 19.5 No No
4W9N_C Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.42 79.2 31.2 Yes Yes
2 empty 1.96 66.6 36.8 No No
3 empty 2.38 67.2 23.5 No No
4 empty 1.98 73.6 16.6 No No
5 empty 2.17 53.3 15.3 No No
6 empty 1.8 62.4 9.4 No No
7 empty 2.18 70.1 12 No No
8 empty 2.11 58.2 12.6 No No
9 empty 1.93 64.3 12.9 No No
10 empty 1.7 70.5 9.3 No No
2JFD_C Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.61 75.4 36.7 Yes Yes
2 empty 2.12 65.6 20.2 No No
3 empty 2.21 66.1 19.5 No No
4 empty 2.27 63.4 15.2 No No
5 empty 2.44 64.4 17.4 No No
6 empty 2.07 64.7 11.9 No No
7 empty 2.22 67.5 17.6 No No
8 empty 1.41 71.7 12.5 No No
9 empty 1.64 69.6 10.6 No No
10 empty 2.26 59.4 12.2 No No
4W82_B Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.47 70.9 32.8 Yes Yes
2 empty 2.44 66.5 27 No No
3 empty 2.22 62.9 24.2 No No
4 empty 1.91 64.4 23.6 No No
5 empty 1.98 70.9 15.9 No No
6 empty 1.94 65.2 20.6 No No
7 empty 1.82 63.8 13.1 No No
8 empty 2.37 73.2 11.1 No No
9 empty 2.3 70.2 11.9 No No
10 empty 2.41 60.9 12.2 No No
2JFD_D Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.5 78 38.4 Yes Yes
2 empty 2.35 67.7 37.4 No No
3 empty 2.4 70.1 27.7 No No
4 empty 2.12 70.5 12.4 No No
5 empty 1.09 77.9 18.6 No No
6 empty 1.49 64.8 18.7 No No
7 empty 1.58 72.2 16.7 No No
8 empty 2.26 69.9 14.6 No No
9 empty 1.19 70.1 10.8 No No
10 empty 1.65 61.9 10.9 No No
3HHD_B Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.6 72.7 36.5 Yes Yes
2 empty 2.41 69.1 33.2 No No
3 empty 2.35 67.3 38.5 No No
4 empty 1.91 63.1 37.3 No No
5 empty 2.08 64.9 23.3 No No
6 empty 1.48 81.4 19.7 No No
7 empty 2.31 68.9 24.8 No No
8 empty 2.27 63.8 17.1 No No
9 empty 2.25 64.7 20.8 No No
10 empty 1.81 64.4 22.3 No No
2JFK_A Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 72 41.3 Yes Yes
2 empty 2.03 69.4 18.1 No No
3 empty 2.05 64.6 18.8 No No
4 empty 2.12 68.7 19.6 No No
5 empty 1.88 59.4 17.7 No No
6 empty 1.69 63.8 18.5 No No
7 empty 1.88 62.8 17.5 No No
8 empty 1.92 77.3 11.9 No No
9 empty 1.82 74 8.1 No No
10 empty 2.15 66.1 11 No No
3TJM_A Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 78.9 32.9 Yes Yes
2 empty 2.31 68 33.9 No No
3 empty 2.29 60.5 26.4 No No
4 empty 2.11 63.8 15.6 No No
5 empty 2.23 67.8 12.7 No No
6 empty 2.22 63.8 16.8 No No
7 empty 2.5 56.3 20.7 No No
8 empty 1.9 70 9.9 No No
9 empty 1.96 68 10.8 No No
10 empty 2.12 59.5 11.9 No No
2JFK_C Fatty acid synthase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 71.1 37.1 Yes No
2 empty 2.24 64.6 36.8 No No
3 empty 1.92 63.4 22.9 No No
4 empty 1.98 69.5 21.5 No No
5 empty 2.16 59.6 20.8 No No
6 empty 1.79 62.9 21.5 No No
7 empty 1.98 61.3 15.5 No No
8 empty 1.92 61.4 21 No No
9 empty 1.86 70.2 13.4 No No
10 empty 2.42 72.6 7.6 No No
3HHD_C Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 67.7 46 Yes Yes
2 empty 2.49 67.9 37 No No
3 empty 1.59 77 25.5 No No
4 empty 2.03 70.9 27.1 No No
5 empty 2.36 61.8 22.7 No No
6 empty 1.53 80.3 18.1 No No
7 empty 2.3 69.2 27.5 No No
8 empty 2.15 67.9 21.6 No No
9 empty 2.12 66.9 16.7 No No
10 empty 2.5 67.4 19.3 No No
4W9N_A Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 76.6 33.3 Yes Yes
2 empty 1.84 67.9 39.3 No No
3 empty 2.51 64.1 25.1 No No
4 empty 1.9 63.9 19.5 No No
5 empty 2.24 54.9 17.1 No No
6 empty 2.15 65.5 15.5 No No
7 empty 2.25 66.9 20.1 No No
8 empty 2 70.3 11 No No
9 empty 1.69 64.8 13.6 No No
10 empty 1.67 67.4 10.2 No No
4Z49_A Fatty acid synthase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 65 30.9 Yes No
2 empty 2.36 66.6 26.7 No No
3 empty 2.35 70 20.4 No No
4 empty 2.25 68.1 13.4 No No
5 empty 2.08 58.6 16.1 No No
6 empty 2 63.2 19.9 No No
7 empty 2.1 74.4 11.4 No No
8 empty 2.2 62.1 12.4 No No
9 empty 2.06 68.8 11.4 No No
10 empty 1.69 71 11.5 No No
6NNA_A Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 74.4 26.6 Yes Yes
2 bound 1.73 62.5 25.2 No No
3 empty 1.97 59.2 27 No No
4 bound 1.87 71.3 20.9 No No
5 empty 2.08 62.2 25.5 No No
6 bound 2.26 69 18.9 No No
7 empty 2.17 67.7 15.8 No No
8 empty 1.72 66.1 14.5 No No
9 empty 2.43 66.6 16.8 No No
10 empty 1.92 89.7 0 Yes No
5C37_A Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 74 30.8 Yes Yes
2 empty 1.81 60.5 25 No No
3 empty 1.82 64.8 26.8 No No
4 empty 2.13 63.7 28 No No
5 empty 2.12 60.1 26.3 No No
6 empty 1.95 63.7 20.4 No No
7 empty 2.02 73.9 16.3 No No
8 bound 1.76 94 0 Yes No
9 empty 2.1 54.9 21.3 No No
10 empty 2.16 67.2 15 No No
4PIV_A Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 76.4 32.4 Yes Yes
2 empty 2.06 67.4 29.7 No No
3 empty 1.68 65.3 20.6 No No
4 empty 2 67.2 22.3 No No
5 empty 2.08 69.6 22.6 No No
6 bound 1.87 61.3 23.5 No No
7 empty 1.85 92.9 0 Yes No
8 empty 1.84 68.4 15.8 No No
9 empty 1.81 58.3 15.1 No No
10 empty 2.05 62.2 20.9 No No
1XKT_A Fatty acid synthase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 66.2 48.7 Yes Yes
2 empty 2.18 65.9 27.4 No No
3 empty 2.37 64.6 17.8 No No
4 empty 1.95 64.8 14.4 No No
5 empty 2.44 72.2 10.7 No No
6 empty 2.35 62.5 12.9 No No
7 empty 2.29 54.5 15 No No
8 empty 2.18 71.3 9.3 No No
9 empty 2.43 71.4 11.1 No No
10 empty 2.02 73.9 11.9 No No
2CG5_B Fatty acid synthase No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 59 18.6 No No
2 empty 2.05 67.9 9.7 No No
3 empty 1.97 60.4 11.2 No No
4 empty 2.63 61.6 10.6 No No
5 empty 2.09 68.7 6.5 No No
6 empty 2.47 65.3 9.8 No No
7 empty 1.97 64.6 7.1 No No
8 empty 2.59 62.2 5.8 No No
9 empty 2.4 55.6 5.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed16
Domains assessed as druggable using the strict criteria10
Domains assessed as druggable using the relaxed criteria13

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1XKT_B (115424) Fatty acid synthase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Thioesterase domain of polypeptide polyketide and fatty acid synthases 2.6Å Yes Yes
1XKT_A (115423) Fatty acid synthase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Thioesterase domain of polypeptide polyketide and fatty acid synthases 2.6Å Yes No
2CG5_B (3060042) Fatty acid synthase Acyl carrier protein-like, ACP-like, Acyl-carrier protein (ACP) 2.7Å No No
2JFD_A (3130450) Fatty acid synthase PFAM, PFAM, PFAM Acyl_transf_1 2.8Å Yes Yes
2JFD_A (3130449) Fatty acid synthase P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, RecA protein-like (ATPase-domain) 2.8Å No No
2JFK_A (3130453) Fatty acid synthase PFAM, PFAM, PFAM Acyl_transf_1 2.4Å Yes Yes
2JFK_A (3130452) Fatty acid synthase P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, RecA protein-like (ATPase-domain) 2.4Å No No
2PX6_A (3180306) Fatty acid synthase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Thioesterase domain of polypeptide polyketide and fatty acid synthases 2.3Å Yes Yes
3HHD_B (4255345) Fatty acid synthase Thiolase-like, Thiolase-like, Thiolase-related (Homo Multimer) 2.15Å Yes Yes
3HHD_A (4183310) Fatty acid synthase Thiolase-like, Thiolase-like, Thiolase-related (Homo Multimer) 2.15Å Yes Yes
3HHD_D (4183310) Fatty acid synthase Thiolase-like, Thiolase-like, Thiolase-related (Homo Multimer) 2.15Å Yes Yes
3HHD_A (3450934) Fatty acid synthase Cytochrome P450, Cytochrome P450, Cytochrome P450 2.15Å Yes No
3HHD_A (3450932) Fatty acid synthase P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, RecA protein-like (ATPase-domain) 2.15Å Yes No
3HHD_A (3450931) Fatty acid synthase Thiolase-like, Thiolase-like, UNMATCHED 2.15Å Yes Yes
3HHD_A (3450930) Fatty acid synthase Thiolase-like, Thiolase-like, UNMATCHED 2.15Å Yes Yes
3HHD_C (4255345) Fatty acid synthase Thiolase-like, Thiolase-like, Thiolase-related (Homo Multimer) 2.15Å Yes Yes
3HHD_A (3450933) Fatty acid synthase PFAM, PFAM, PFAM Acyl_transf_1 2.15Å Yes Yes
3TJM_A (3710863) Fatty acid synthase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Thioesterase domain of polypeptide polyketide and fatty acid synthases 1.48Å Yes Yes
Ligand-based Druggability Score: 1.05
Ligand-based Druggability Score Percentile: 91%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


FASN is involved in 7 interactions in the network.


Druggability
Overall Druggability Percentile: 79.57
Druggability for Cancer Therapeutics: 70.48
Druggability for Other Therapeutics: 95.62
Cancer-Associated
Cancer-associated percentile : 68.25
Network Articulation Point
Is FASN critical for communication in the network?


Detailed Graph Legend:Help