FASN (P49327) - Overview - Molecular Target Synopsis
FASN, Fatty acid synthase
Enzyme Classification 188.8.131.52
Also Known as FAS_HUMAN, FASN, FAS
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. Homodimer which is arranged in a head to tail fashion (PubMed:17618296, PubMed:18022563, Ref.28). Interacts with CEACAM1; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity.
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UniProt: FASN is active in the following subcellular-locations: cytoplasm, melanosome.
GO terms: FASN is active in the following subcellular-locations: cytosol, extracellular exosome, glycogen granule, Golgi apparatus, melanosome, membrane, plasma membrane.