Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FASN (P49327) - Overview - Molecular Target Synopsis

Protein


FASN, Fatty acid synthase
Enzyme Classification 2.3.1.85
UniProt P49327

Also Known as FAS_HUMAN, FASN, FAS

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. Homodimer which is arranged in a head to tail fashion (PubMed:17618296, PubMed:18022563, Ref.28). Interacts with CEACAM1; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
2511ENSG00000169710ENST00000306749ENSP00000304592P49327-1
84ENSG00000169710ENST00000580382ENSP00000462949

Sub-cellular localization


UniProt: FASN is active in the following subcellular-locations: cytoplasm, melanosome.
GO terms: FASN is active in the following subcellular-locations: cytosol, extracellular exosome, glycogen granule, Golgi apparatus, melanosome, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FASN has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, MALME_3M, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-175-VII, HCC2688, YMB-1-E

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HMEC

(see details)

3D Structures


For FASN there are:
13 structures (32 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FASN has been screened with 679 compounds (734 bioactivities), 348 compounds have bioactivities that show binding affinity of <= 500nM (369 bioactivities). (see details)