Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PXN (P49024) - Overview - Molecular Target Synopsis

Protein


PXN, Paxillin
UniProt P49024

Also Known as PAXI_CHICK, PXN

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of v-CRK.

4R32
11 RESIDUE FRAGMENT OF
PAXILLIN
IN THE STRUCTURE OF
CRYSTAL STRUCTURE ANALYSIS OF PYK2 AND PAXILLIN LD MOTIFS
RCSB/PDB
Inspect Structure
See all 3D Structures for PXN

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
559P49024-1

Sub-cellular localization


UniProt: PXN is active in the following subcellular-locations: cell junction, cytoplasm, cytoskeleton, focal adhesion.
GO terms: PXN is active in the following subcellular-locations: cell, cytoplasm, focal adhesion, plasma membrane, stress fiber.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PXN has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For PXN there are:
4 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PXN has been screened with compounds ( bioactivities). (see details)