Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRPC1 (P48995) - Overview - Molecular Target Synopsis

Protein


TRPC1, Short transient receptor potential channel 1
UniProt P48995

Also Known as TRPC1_HUMAN, TRPC1, TRP1

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TRPC1 is active in the following subcellular-locations: membrane.
GO terms: TRPC1 is active in the following subcellular-locations: cation channel complex, integral component of plasma membrane, plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRPC1 has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RXF_393, SF_539, UO_31

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 578T, NCI-H2196, NCI-H2596

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, hMSC-AT, HFDPC

(see details)

3D Structures


At greater than 35% identity similarity to TRPC1 there are:
4 structures (16 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TRPC1 has been screened with compounds ( bioactivities). (see details)