Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MASP1 (P48740) - Overview - Molecular Target Synopsis

Protein


MASP1, Mannan-binding lectin serine protease 1
Enzyme Classification 3.4.21.-
UniProt P48740

Also Known as MASP1_HUMAN, MASP1, CRARF, CRARF1, PRSS5

Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343). Homodimer. Interacts with the oligomeric lectins MBL2, FCN2 and FCN3; triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1. Interacts with COLEC11; probably triggers the lectin pathway of complement (PubMed:20956340).

4KKD
THE X-RAY CRYSTAL STRUCTURE OF MANNOSE-BINDING LECTIN-ASSOCIATED SERINE PROTEINASE-3 REVEALS THE STRUCTURAL BASIS FOR ENZYME INACTIVITY ASSOCIATED WITH THE 3MC SYNDROME
RCSB/PDB
Inspect Structure
See all 3D Structures for MASP1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MASP1 is active in the following subcellular-locations: secreted.
GO terms: MASP1 is active in the following subcellular-locations: cytosol, extracellular region, extracellular space, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MASP1 has gain in 9 cell-lines, loss in 1 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, KM12, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 675.T, HuH-7, Hs 839.T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: BJ, NHLF, AG445

(see details)

3D Structures


For MASP1 there are:
7 structures (14 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MASP1 has been screened with compounds ( bioactivities). (see details)