MASP1 (P48740) - Overview - Molecular Target Synopsis
MASP1, Mannan-binding lectin serine protease 1
Enzyme Classification 3.4.21.-
Also Known as MASP1_HUMAN, MASP1, CRARF, CRARF1, PRSS5
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343). Homodimer. Interacts with the oligomeric lectins MBL2, FCN2 and FCN3; triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1. Interacts with COLEC11; probably triggers the lectin pathway of complement (PubMed:20956340).
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UniProt: MASP1 is active in the following subcellular-locations: secreted.
GO terms: MASP1 is active in the following subcellular-locations: cytosol, extracellular region, extracellular space, nucleoplasm.