Molecular Target Synopsis
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Druggability
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infB (P48515) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed11
Chains with at least one site assessed as druggable using the strict criteria7
Chains with at least one site assessed as druggable using the relaxed criteria11


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4KJZ_D Translation initiation factor IF-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 64.8 29.7 Yes No
2 empty 1.93 77.2 22.6 No No
3 empty 2.46 69.2 29 No No
4 empty 2.46 63.1 28.8 No No
5 empty 2.26 64.4 20.5 No No
6 empty 2.12 61.8 24.6 No No
7 empty 2.11 67.1 20.4 No No
8 empty 2.62 62.1 21.8 No No
9 empty 2.43 72 14.2 No No
10 empty 2.17 67 20.7 No No
4B44_A Translation initiation factor IF-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 71.5 42.3 Yes Yes
2 empty 2.13 66.9 23.5 No No
3 empty 1.97 67.9 22.7 No No
4 empty 2.01 66 15.1 No No
5 bound 2.17 66 15.4 No No
6 empty 2.35 61.2 14.4 No No
7 empty 1.9 72.3 15.4 No No
8 empty 2.45 59.4 22 No No
9 empty 1.91 63.2 17.3 No No
10 empty 1.86 66 10.3 No No
4B47_A Translation initiation factor IF-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 69.8 37.1 Yes Yes
2 empty 2.04 66.2 27.6 No No
3 empty 2.18 63.6 22.6 No No
4 empty 1.92 72.4 24 No No
5 empty 2.23 64.6 13.1 No No
6 empty 2.04 62.9 15.9 No No
7 empty 1.96 75.4 14.4 No No
8 empty 2.45 60.9 13.6 No No
9 empty 2.22 72.4 11.4 No No
10 empty 2.29 55.2 20.3 No No
5LMV_a Translation initiation factor IF-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 61.8 53.3 Yes No
2 empty 1.91 63.8 32.6 No No
3 empty 2.14 64.9 28 No No
4 empty 2.36 67.3 33.3 No No
5 empty 2.32 57.5 25.2 No No
6 empty 2.33 71.1 21.7 No No
7 empty 2.07 66 29.2 No No
8 empty 1.86 97.3 0 Yes No
9 empty 2.23 70.4 17.4 No No
10 empty 2.49 48.7 16.7 No No
3J4J_A Translation initiation factor IF-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 71.1 56.9 Yes Yes
2 empty 2.46 69.9 46.3 No No
3 empty 2.43 60 26.1 No No
4 empty 2.73 71.5 28.6 No No
5 empty 2.28 63.1 20 No No
6 empty 2.42 70.3 19.7 No No
7 empty 2.08 66.1 17.9 No No
8 empty 2.3 55.8 18.8 No No
9 empty 2.51 70.6 20.3 No No
10 empty 2.25 66.2 13.8 No No
4B43_A Translation initiation factor IF-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 67.2 36.1 Yes Yes
2 bound 2.23 65.7 44.3 No No
3 empty 1.96 64.1 18.4 No No
4 empty 2.16 67.3 22.9 No No
5 empty 2.22 58.3 17.8 No No
6 bound 2 73.2 15 No No
7 empty 2.43 65.1 12.5 No No
8 empty 2.48 60.7 15.7 No No
9 empty 2.28 68 12.1 No No
10 empty 2.26 62.6 16.5 No No
4B3X_A Translation initiation factor IF-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 69.5 45.3 Yes Yes
2 empty 2.04 68.8 30.7 No No
3 empty 2.12 70.6 18 No No
4 empty 2.26 64.3 16.3 No No
5 empty 2.11 60.1 23.6 No No
6 empty 2.14 61.6 21.2 No No
7 bound 2.24 73.3 15 No No
8 empty 2.44 61.1 22.3 No No
9 empty 2.32 67 16.7 No No
10 empty 2.22 50.3 13.8 No No
4KJZ_B Translation initiation factor IF-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 70.1 35.4 Yes Yes
2 empty 2.29 70.4 33.1 No No
3 empty 2.09 61.7 31.7 No No
4 empty 1.9 80.7 21.3 No No
5 empty 2.59 60.3 25.8 No No
6 empty 2.28 65.7 22.2 No No
7 empty 2.02 65 20.8 No No
8 empty 2.01 57.8 19.9 No No
9 empty 2.09 59.2 24.9 No No
10 empty 2.34 48.4 21.4 No No
4KJZ_C Translation initiation factor IF-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 53.7 34.1 Yes No
2 empty 1.79 69.6 27.3 No No
3 empty 2.02 69 22.6 No No
4 empty 2.03 62.6 22 No No
5 empty 2.24 89.2 13.3 Yes No
6 empty 2.22 52.1 17.7 No No
7 empty 2.16 64.5 18.4 No No
8 bound 2.06 69.3 12.9 No No
9 empty 2.28 53.2 13.8 No No
10 empty 1.94 62.9 17.9 No No
4B48_A Translation initiation factor IF-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 67 53.5 Yes Yes
2 empty 2.03 65 23.2 No No
3 empty 1.9 68.6 18.4 No No
4 empty 2.25 61.4 15.8 No No
5 empty 1.98 75.4 15 No No
6 empty 2.01 66.8 15.4 No No
7 empty 2.23 54.6 16.2 No No
8 empty 2.29 60.3 15.5 No No
9 empty 1.99 61.4 15.3 No No
10 empty 1.85 66.9 13.1 No No
4KJZ_A Translation initiation factor IF-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 65.7 40.7 Yes No
2 empty 2.02 58.2 31.9 No No
3 empty 1.89 67.1 20.2 No No
4 empty 2.45 69 20.1 No No
5 empty 2.36 65.4 19.9 No No
6 empty 2.36 59.4 18.3 No No
7 empty 2.21 62.9 15.4 No No
8 empty 2.41 57.3 15.1 No No
9 empty 2.27 64.7 13.6 No No
10 empty 2.11 49.2 15 No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score