Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

infB (P48515) - Overview - Molecular Target Synopsis

Protein


infB, Translation initiation factor IF-2
UniProt P48515

Also Known as IF2_THET8, infB

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

5LMV
STRUCTURE OF BACTERIAL 30S-IF1-IF2-IF3-MRNA-TRNA TRANSLATION PRE- INITIATION COMPLEX(STATE-III)
RCSB/PDB
Inspect Structure
See all 3D Structures for infB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: infB is active in the following subcellular-locations: cytoplasm.
GO terms: infB is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project infB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For infB there are:
8 structures (11 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis