Molecular Target Synopsis
Overview
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Druggability
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Il15 (P48346) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed2
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria0


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2PSM_A Interleukin-15 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 69.4 18.7 No No
2 empty 2.3 69.4 14.4 No No
3 empty 2.48 66.2 18 No No
4 empty 2.32 62.1 12.7 No No
5 empty 2.58 62.1 11.3 No No
6 empty 2.1 63.4 9.7 No No
7 empty 1.57 66.1 7.7 No No
8 empty 2.18 66.9 6.8 No No
9 empty 2.26 63.2 8.7 No No
10 empty 2.69 56.4 8.3 No No
2PSM_B Interleukin-15 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 68.5 19.6 No No
2 empty 2.52 71.5 9.4 No No
3 empty 2.46 59.7 12.1 No No
4 empty 2.47 80.6 12.3 No No
5 empty 1.78 66.9 10.8 No No
6 empty 2.63 64.7 13.3 No No
7 empty 2.14 68.7 11 No No
8 empty 2.39 54.7 9.9 No No
9 empty 1.87 65.5 7.2 No No
10 empty 1.84 73.4 6.5 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria1

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2PSM_B (149821) Interleukin-15 4-helical cytokines, 4-helical cytokines, Short-chain cytokines 2.19Å Yes No
2PSM_A (149820) Interleukin-15 4-helical cytokines, 4-helical cytokines, Short-chain cytokines 2.19Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score