Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

AVPR2 (P48044) - Overview - Molecular Target Synopsis


AVPR2, Vasopressin V2 receptor
UniProt P48044

Also Known as V2R_BOVIN, AVPR2

Receptor for arginine vasopressin (PubMed:7698346, PubMed:8257689). The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. Interacts with ARRDC4. Identified in a complex containing at least ARRDC4, V2R and HGS.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: AVPR2 is active in the following subcellular-locations: cell membrane.
GO terms: AVPR2 is active in the following subcellular-locations: integral component of plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project AVPR2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference

AVPR2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

Screening and Chemistry

AVPR2 has been screened with 24 compounds (34 bioactivities), 21 compounds have bioactivities that show binding affinity of <= 500nM (21 bioactivities). (see details)