Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

XDH (P47989) - Overview - Molecular Target Synopsis

Protein


XDH, Xanthine dehydrogenase/oxidase
Enzyme Classification 1.17.1.4
UniProt P47989

Also Known as XDH_HUMAN, XDH, XDHA

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). Homodimer. Interacts with BTN1A1.

2E1Q
CRYSTAL STRUCTURE OF HUMAN XANTHINE OXIDOREDUCTASE MUTANT, GLU803VAL
RCSB/PDB
Inspect Structure
See all 3D Structures for XDH

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1333ENSG00000158125ENST00000379416ENSP00000368727P47989-1

Drugs


XDH is targeted by Approved Drugs Allopurinol, Febuxostat. (see details)
Allopurinol
Febuxostat

Sub-cellular localization


UniProt: XDH is active in the following subcellular-locations: cytoplasm, peroxisome, secreted.
GO terms: XDH is active in the following subcellular-locations: cytosol, extracellular space, peroxisome, sarcoplasmic reticulum.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project XDH has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, NCI_ADR_RES, IGROV1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MCF10DCIS.com, HCC364, OVCAR-5

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHEK, SK-N-SH

(see details)

RNA Interference


XDH was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For XDH there are:
2 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

XDH is solved in complex with the approved drug(s):

SAL/SALICYLIC ACID (2E1Q_A, 2E1Q_B, 2E1Q_C, 2E1Q_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


XDH has been screened with 438 compounds (615 bioactivities), 42 compounds have bioactivities that show binding affinity of <= 500nM (50 bioactivities). (see details)