Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
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P2RY1 (P47900) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/04/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 02/04/2019)


Chains assessed3
Chains with at least one site assessed as druggable using the strict criteria3
Chains with at least one site assessed as druggable using the relaxed criteria3


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4XNV_A P2Y purinoceptor 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 68.2 35.8 Yes Yes
2 bound 1.45 65.8 29.2 No No
3 empty 1.95 58.4 23.1 No No
4 empty 2.01 63.5 17.4 No No
5 empty 2.24 60.7 15.5 No No
6 bound 1.69 54.8 15.7 No No
7 empty 2.03 43.2 12 No No
8 empty 2.2 63.7 9.7 No No
9 empty 1.97 55.4 10.8 No No
10 bound .85 59.5 11.8 No No
4XNW_A P2Y purinoceptor 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 71.9 31.4 Yes Yes
2 empty 1.87 63.2 30.5 No No
3 empty 1.63 67.2 24 No No
4 empty 1.28 68.8 18.8 No No
5 empty 1.48 77.1 17.6 No No
6 empty .86 68.5 20 No No
7 empty 2.23 61.1 13.5 No No
8 empty 2.14 66.9 11.9 No No
9 empty 1.29 68 12.1 No No
10 empty 2.53 60.1 15.9 No No
4XNW_C P2Y purinoceptor 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 74.7 29.3 Yes Yes
2 empty 1.63 64.5 40.8 No No
3 empty 1.16 68.2 18.3 No No
4 empty 2.21 64 14.5 No No
5 empty 2.1 49 22.7 No No
6 empty 2.02 63.8 15.8 No No
7 empty .88 68 21.8 No No
8 empty 2.48 63.5 20.3 No No
9 empty 2.37 57.7 12.4 No No
10 empty 1.1 63.5 14.2 No No
Ligand-based Druggability Score: -0.1
Ligand-based Druggability Score Percentile: 78%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


P2RY1 is involved in 3 interactions in the network.


Druggability
Overall Druggability Percentile: 27.40
Druggability for Cancer Therapeutics: 40.10
Druggability for Other Therapeutics: 82.84
Cancer-Associated
Cancer-associated percentile : 12.36
Network Articulation Point
Is P2RY1 critical for communication in the network?


Detailed Graph Legend:Help