Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

P2RY1 (P47900) - Overview - Molecular Target Synopsis

Protein


P2RY1, P2Y purinoceptor 1
UniProt P47900

Also Known as P2RY1_HUMAN, P2RY1

Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040).

4XNV
THE HUMAN P2Y1 RECEPTOR IN COMPLEX WITH BPTU
RCSB/PDB
Inspect Structure
See all 3D Structures for P2RY1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
642ENSG00000169860ENST00000305097ENSP00000304767
373P47900-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project P2RY1 has gain in 8 cell-lines, loss in 0 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, TK_10, PC_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, ME-180, KU812

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, NHLF

(see details)

3D Structures


For P2RY1 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

P2RY1 is solved in complex with the approved drug(s):

CLR/CHOLESTEROL (4XNV_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


P2RY1 has been screened with 594 compounds (1014 bioactivities), 314 compounds have bioactivities that show binding affinity of <= 500nM (522 bioactivities). (see details)