GABRA2 (P47869) - Overview - Molecular Target Synopsis
GABRA2, Gamma-aminobutyric acid receptor subunit alpha-2
Also Known as GBRA2_HUMAN, GABRA2
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (By similarity). Interacts with UBQLN1 (By similarity). Interacts with KIF21B (By similarity). Interacts with LHFPL4 (By similarity).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|451||ENSG00000151834||ENST00000356504, ENST00000510861, ENST00000381620, ENST00000514090||ENSP00000348897, ENSP00000421828, ENSP00000371033, ENSP00000421300||P47869-1|
UniProt: GABRA2 is active in the following subcellular-locations: cell junction, cell membrane, cell projection, cytoplasmic vesicle membrane, dendrite, postsynaptic cell membrane, synapse.
GO terms: GABRA2 is active in the following subcellular-locations: cell junction, chloride channel complex, dendrite membrane, GABA-A receptor complex, integral component of plasma membrane, integral component of synaptic vesicle membrane, neuron projection, plasma membrane, postsynapse, postsynaptic membrane, synapse.