Ace (P47820) - Overview - Molecular Target Synopsis
Ace, Angiotensin-converting enzyme
Enzyme Classification 3.2.1.-
Also Known as ACE_RAT, Ace, Dcp1
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm.
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UniProt: Ace is active in the following subcellular-locations: cell membrane, cytoplasm, secreted.
GO terms: Ace is active in the following subcellular-locations: basal plasma membrane, brush border membrane, cytoplasm, endosome, external side of plasma membrane, extracellular exosome, extracellular space, integral component of membrane, lysosome, plasma membrane, sperm midpiece, vesicle.