Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Ace (P47820) - Overview - Molecular Target Synopsis

Protein


Ace, Angiotensin-converting enzyme
Enzyme Classification 3.2.1.-
UniProt P47820

Also Known as ACE_RAT, Ace, Dcp1

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1313P47820-1
775P47820-2

Sub-cellular localization


UniProt: Ace is active in the following subcellular-locations: cell membrane, cytoplasm, secreted.
GO terms: Ace is active in the following subcellular-locations: basal plasma membrane, brush border membrane, cytoplasm, endosome, external side of plasma membrane, extracellular exosome, extracellular space, integral component of membrane, lysosome, plasma membrane, sperm midpiece, vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Ace has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


Ace was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)


Screening and Chemistry


Ace has been screened with 597 compounds (1094 bioactivities), 285 compounds have bioactivities that show binding affinity of <= 500nM (328 bioactivities). (see details)