Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

lpxC (P47205) - Overview - Molecular Target Synopsis

Protein


lpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase
Enzyme Classification 3.5.1.108
UniProt P47205

Also Known as LPXC_PSEAE, lpxC, envA

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

6MAE
CHAIN A. UDP-3-O-[3-HYDROXYMYRISTOYL] N-ACETYLGLUCOSAMINE DEACETYLASE PA-LPXC COMPLEXED WITH (R)-3-((S)-3-(4-(CYCLOPROPYLETHYNYL)PHENYL)-2- OXOOXAZOLIDIN-5-YL)-N-HYDROXY-2-METHYL-2-(METHYLSULFONYL)PROPENAMIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for lpxC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
303P47205-1, B7UZI4-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project lpxC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For lpxC there are:
22 structures (44 chains) solved
22 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


lpxC has been screened with 342 compounds (348 bioactivities), 248 compounds have bioactivities that show binding affinity of <= 500nM (252 bioactivities). (see details)