Molecular Target Synopsis
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RPA34 (P47006) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed25
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria24


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6H68_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 69.4 31.6 Yes No
2 empty 1.79 52.6 24 No No
3 empty 2.32 64.2 24.3 No No
4 empty 1.77 63.9 27.3 No No
5 empty 2.44 65.4 18 No No
6 empty 2.51 65.8 17.5 No No
7 empty 2.04 63.1 19 No No
8 empty 2.14 57.3 13.5 No No
9 empty 2.3 44.6 14.1 No No
10 empty 1.97 56.9 15.4 No No
5OA1_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.49 58.8 28.4 Yes No
2 empty 2.04 55.1 18.4 No No
3 empty 2.55 71.9 17.4 No No
4 empty 2.48 62.1 19.6 No No
5 empty 2.58 65.5 17.1 No No
6 empty 2.17 62.8 18.2 No No
7 empty 2.12 62.7 13.5 No No
8 empty 1.46 69.1 12.4 No No
9 empty 2.57 61.2 13.9 No No
10 empty 2.44 59.2 13.2 No No
5M5W_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 60.9 39.8 Yes No
2 empty 1.62 61.2 18.1 No No
3 empty 1.48 48.4 21 No No
4 empty 1.84 56.1 19.4 No No
5 empty 2.37 60.1 12.9 No No
6 empty 1.91 59.4 17.7 No No
7 empty 1.92 61.9 11.3 No No
8 empty 1.8 66.7 13.5 No No
9 empty 1.98 62.4 9.9 No No
10 empty 2.1 58.5 12.9 No No
5G5L_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.82 65 33.5 Yes No
2 empty 2.35 63 17.2 No No
3 empty 1.36 55.6 16.6 No No
4 empty 1.74 58.4 14.2 No No
5 empty 2.36 56.8 13.5 No No
6 empty 2.08 60.9 15.9 No No
7 empty 1.92 47.6 12.7 No No
8 empty 1.63 68.6 11.4 No No
9 empty 2.09 66.8 13.7 No No
10 empty 2.44 51 11.1 No No
6H67_N DNA-directed RNA polymerase I subunit RPA34 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 66.5 26.5 Yes Yes
2 empty 2.33 59.5 24.5 No No
3 empty 2.15 56.8 16.7 No No
4 empty 2.69 68.2 12.1 No No
5 empty 2.04 55 15.2 No No
6 empty 2.49 59.9 14.9 No No
7 empty 1.67 64.9 14 No No
8 empty 2.12 46.9 10.2 No No
9 empty 1.94 61.4 13.1 No No
10 empty 2 53.8 10.2 No No
5M64_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.65 65.1 33.7 Yes No
2 empty 1.97 53.4 20 No No
3 empty 1.84 84.3 18.1 Yes No
4 empty 2.42 61.3 15.7 No No
5 empty 1.76 62.9 15 No No
6 empty 2.33 72.7 12.9 No No
7 empty 2.3 51.9 13.5 No No
8 empty 2.05 52.1 16.6 No No
9 empty 1.72 48.6 13.8 No No
10 empty 2.05 55.4 12.6 No No
6HKO_N DNA-directed RNA polymerase I subunit RPA34 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 63 22.5 No No
2 empty 2.51 68.1 25.2 No No
3 empty 2.33 64 16.3 No No
4 empty 1.77 62.5 16.2 No No
5 empty 1.98 51.6 20.7 No No
6 empty 1.81 51.9 16.9 No No
7 empty 1.57 69.6 12 No No
8 empty 2.48 54.2 10.5 No No
9 empty 1.69 52.7 11.9 No No
10 empty 2.08 55 12.4 No No
5N5Z_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.81 65.5 25.4 Yes No
2 empty 2.24 62.9 19.7 No No
3 empty 2.3 62.9 14.9 No No
4 empty 1.57 58.4 16.5 No No
5 empty 2.11 56.1 23.6 No No
6 empty 1.71 57.1 15.7 No No
7 empty 2.1 55.3 18.6 No No
8 empty 2.42 59 12.4 No No
9 empty 1.59 64.7 9.6 No No
10 empty 2.45 49.5 9.3 No No
4C2M_3 DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.8 63.2 30.3 Yes No
2 empty 2.33 63.7 16.1 No No
3 empty 1.72 59.2 20.2 No No
4 empty 1.75 55.2 15 No No
5 empty 1.58 64.7 11.2 No No
6 empty 2.42 68.3 11.7 No No
7 empty 1.69 48.3 11.2 No No
8 empty 2.45 52.3 9.1 No No
9 empty 2.21 62.3 9.8 No No
10 empty 1.97 44 9.5 No No
5W64_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.49 64.6 45.9 Yes No
2 empty 2.52 61.9 24.9 No No
3 empty 2.08 53.6 19.3 No No
4 empty 2.07 53 21.1 No No
5 empty 1.64 78.1 11.6 No No
6 empty 1.53 64.7 10.3 No No
7 empty 2.56 64.3 9.6 No No
8 empty 1.89 51.4 9.4 No No
9 empty 2.66 57.4 8.8 No No
10 empty 2.65 77 8.1 No No
5LMX_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.46 60.7 31.6 Yes No
2 empty 2.09 56.7 18.7 No No
3 empty 2.45 64.6 18.6 No No
4 empty 2.49 69.3 17.7 No No
5 empty 2.54 66.6 17.4 No No
6 empty 1.94 51.3 15.1 No No
7 empty 2.03 67.2 17.5 No No
8 empty 1.92 56.6 17.2 No No
9 empty 1.61 71.3 11.1 No No
10 empty 2.33 69 13.4 No No
5N60_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.78 65.1 34 Yes No
2 empty 2.27 61.1 17.3 No No
3 empty 1.7 56.8 15.4 No No
4 empty 2.22 55.8 25.8 No No
5 empty 1.6 59 14.1 No No
6 empty 2.07 61.1 16 No No
7 empty 2.26 55.3 12.9 No No
8 empty 1.62 67.1 12.3 No No
9 empty 1.69 44.9 11.8 No No
10 empty 2.47 51.3 12.1 No No
5N5Y_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.78 62.8 38.7 Yes No
2 empty 2.27 61.9 16.7 No No
3 empty 1.66 57.1 22 No No
4 empty 2.08 58 15.8 No No
5 empty 1.66 59.1 14.5 No No
6 empty 2.24 56.2 11.7 No No
7 empty 1.74 71.2 11.6 No No
8 empty 2.37 51.1 10 No No
9 empty 1.71 46.2 11.4 No No
10 empty 1.95 43.8 9.5 No No
5W65_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.47 64.5 29.7 Yes No
2 empty 1.9 53.4 22.4 No No
3 empty 2.28 67.4 18.7 No No
4 empty 2.33 59.6 22.5 No No
5 empty 2.12 58.2 19.6 No No
6 empty 2.19 60.9 16.2 No No
7 empty 1.53 58.3 16.4 No No
8 empty 1.66 71.4 12.4 No No
9 empty 2.05 45 12 No No
10 empty 2.84 54.3 10.9 No No
5N61_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 63.8 27 Yes No
2 empty 1.82 58.6 26 No No
3 empty 2.28 65.9 16.2 No No
4 empty 2.22 68.2 16.4 No No
5 empty 1.7 54.6 14.4 No No
6 empty 2.08 50.6 16.8 No No
7 empty 2.25 53.2 12.4 No No
8 empty 1.77 50.2 10.8 No No
9 empty 1.23 68.7 8.2 No No
10 empty 1.95 63 11.5 No No
5M5Y_N DNA-directed RNA polymerase I subunit RPA34 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 69.7 31.4 Yes Yes
2 empty 1.8 54.8 21.2 No No
3 empty 2.45 56.8 15.9 No No
4 empty 1.83 50 13.5 No No
5 empty 2.26 58.4 17.8 No No
6 empty 2.47 67.7 14.1 No No
7 empty 2.29 61.7 12.7 No No
8 empty 1.53 65.9 14.1 No No
9 empty 2.2 68.2 11.4 No No
10 empty 2.42 48.5 12.8 No No
4C2M_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.65 63.6 31.5 Yes No
2 empty 2.36 63 16.7 No No
3 empty 1.6 55.6 16.9 No No
4 empty 2.09 57 18.2 No No
5 empty 1.66 54.7 14.9 No No
6 empty 2.35 57.9 12.9 No No
7 empty 2.28 60.2 15.7 No No
8 empty 1.59 68.6 11.7 No No
9 empty 2.38 53.9 10.5 No No
10 empty 2.12 44.6 9.3 No No
4C3I_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 59.7 29.6 Yes No
2 empty 1.87 53.6 17.4 No No
3 empty 2.43 66.1 17.7 No No
4 empty 2.5 69.2 16.8 No No
5 empty 2.22 63.7 15.9 No No
6 empty 2.59 66.6 18.5 No No
7 empty 2.09 59.1 13.4 No No
8 empty 1.48 71.9 11.2 No No
9 empty 2.29 61.2 12.3 No No
10 empty 2.22 67.1 13.3 No No
5W66_N DNA-directed RNA polymerase I subunit RPA34 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 67.3 33.8 Yes Yes
2 empty 2.17 52.5 21.5 No No
3 empty 2.32 59.4 24.5 No No
4 empty 2.38 61.3 14.6 No No
5 empty 2.59 58 22.2 No No
6 empty 1.54 60.9 14.3 No No
7 empty 1.78 77.6 9.7 No No
8 empty 2.69 76.5 13.9 No No
9 empty 1.84 58.3 11.7 No No
10 empty 2.14 63.6 8.8 No No
5M5X_N DNA-directed RNA polymerase I subunit RPA34 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.61 66.5 37.7 Yes Yes
2 empty 1.72 59.2 19.4 No No
3 empty 1.62 55.3 14.4 No No
4 empty 2.49 61.9 14 No No
5 empty 2.4 68.1 13.5 No No
6 empty 1.75 55.1 11.8 No No
7 empty 2.44 76.3 9 No No
8 empty 2.27 67.8 8.2 No No
9 empty 1.84 48.7 8.6 No No
10 empty 1.88 98.8 0 Yes No
5M3M_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.72 62.5 35.9 Yes No
2 empty 2.33 60.1 18 No No
3 empty 1.55 59.6 14.9 No No
4 empty 1.69 55.5 13.9 No No
5 empty 2.12 59.3 15.1 No No
6 empty 1.75 69.9 12.6 No No
7 empty 2.08 72.7 6.7 No No
8 empty 2.4 50.6 11 No No
9 empty 2.12 43.5 9.9 No No
10 empty 1.57 55.6 10.3 No No
4C3J_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 60.7 29.5 Yes No
2 empty 1.97 56.5 18 No No
3 empty 2.57 68.9 16.7 No No
4 empty 2.15 64 19.1 No No
5 empty 2.52 64.9 18 No No
6 empty 2.1 63.1 13.2 No No
7 empty 1.69 71.7 11.1 No No
8 empty 2.3 59.7 12.7 No No
9 empty 2.46 45.8 16.2 No No
10 empty 1.77 48.2 10.5 No No
5M3F_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.79 63.8 35.4 Yes No
2 empty 2.32 61.7 17.7 No No
3 empty 1.82 60.3 15.2 No No
4 empty 2.01 55.4 19.1 No No
5 empty 1.79 56.9 14.1 No No
6 empty 2.3 55.2 12.8 No No
7 empty 1.77 66.3 9.7 No No
8 empty 2.22 55.7 13.8 No No
9 empty 1.78 45 10.7 No No
10 empty 2.4 54.7 9.1 No No
4C3H_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 60.2 31.8 Yes No
2 empty 2.45 69.6 17 No No
3 empty 2.45 65.8 17.7 No No
4 empty 2.17 62.5 19.6 No No
5 empty 1.95 51.2 14.7 No No
6 empty 1.94 58.9 18 No No
7 empty 2.12 62 12.7 No No
8 empty 2.62 63.5 14.8 No No
9 empty 2.45 60.3 13.5 No No
10 empty 1.44 70.7 12 No No
5W5Y_N DNA-directed RNA polymerase I subunit RPA34 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 62.5 53.6 Yes No
2 empty 2.4 66.7 25.4 No No
3 empty 1.89 53.6 19.3 No No
4 empty 2.45 59.7 24.7 No No
5 empty 1.8 76 10.2 No No
6 empty 1.79 46.1 11.5 No No
7 empty 2.39 58.1 12.7 No No
8 empty 2.21 59.4 10.4 No No
9 empty 1.86 51.2 8.4 No No
10 empty 2.37 86.1 7.8 Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score