MAP1B (P46821) - Overview - Molecular Target Synopsis
MAP1B, Microtubule-associated protein 1B
Also Known as MAP1B_HUMAN, MAP1B
Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino-terminal region of MAP1B. Interacts with ANP32A and TIAM2. Interacts with the tubulin tyrosine TTL (By similarity). Interacts (via C-terminus) with GAN (via Kelch domains) (PubMed:12147674, PubMed:16227972). Interacts (via N-terminus) with DAPK1 (PubMed:18195017). Interacts with TMEM185A (PubMed:15525354). Interacts with MAP1LC3B (PubMed:24089205). Interacts with KIRREL3 (PubMed:25902260).
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UniProt: MAP1B is active in the following subcellular-locations: cell junction, cell projection, cytoplasm, cytoskeleton, dendritic spine, synapse.
GO terms: MAP1B is active in the following subcellular-locations: apical dendrite, axon, basal dendrite, cell junction, cell projection, cytosol, dendrite, dendritic spine, growth cone, hippocampal mossy fiber, microtubule, microtubule associated complex, neuronal cell body, perikaryon, perinuclear region of cytoplasm, photoreceptor outer segment, plasma membrane, postsynaptic density, somatodendritic compartment, synapse, varicosity.