Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAP1B (P46821) - Overview - Molecular Target Synopsis

Protein


MAP1B, Microtubule-associated protein 1B
UniProt P46821

Also Known as MAP1B_HUMAN, MAP1B

Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino-terminal region of MAP1B. Interacts with ANP32A and TIAM2. Interacts with the tubulin tyrosine TTL (By similarity). Interacts (via C-terminus) with GAN (via Kelch domains) (PubMed:12147674, PubMed:16227972). Interacts (via N-terminus) with DAPK1 (PubMed:18195017). Interacts with TMEM185A (PubMed:15525354). Interacts with MAP1LC3B (PubMed:24089205). Interacts with KIRREL3 (PubMed:25902260).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MAP1B is active in the following subcellular-locations: cell junction, cell projection, cytoplasm, cytoskeleton, dendritic spine, synapse.
GO terms: MAP1B is active in the following subcellular-locations: apical dendrite, axon, basal dendrite, cell junction, cell projection, cytosol, dendrite, dendritic spine, growth cone, hippocampal mossy fiber, microtubule, microtubule associated complex, neuronal cell body, perikaryon, perinuclear region of cytoplasm, photoreceptor outer segment, plasma membrane, postsynaptic density, somatodendritic compartment, synapse, varicosity.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAP1B has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_19, NCI_H226, U251

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G112, HCC12, G122

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, SK-N-SH

(see details)


Screening and Chemistry


MAP1B has been screened with 5 compounds (14 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)