MAP2K3 (P46734) - Overview - Molecular Target Synopsis
MAP2K3, Dual specificity mitogen-activated protein kinase kinase 3
Enzyme Classification 22.214.171.124
Also Known as MP2K3_HUMAN, MAP2K3, MEK3, MKK3, PRKMK3, SKK2
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Binds to DYRK1B/MIRK and increases its kinase activity (PubMed:11980910). Part of a complex with MAP3K3, RAC1 and CCM2 (By similarity). Interacts with ARRB1 (PubMed:16709866). Interacts with Yersinia yopJ (PubMed:16728640).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|318||ENSG00000034152||ENST00000361818, ENST00000316920||ENSP00000355081, ENSP00000319139||P46734-2|
GO terms: MAP2K3 is active in the following subcellular-locations: cytoplasm, cytosol, membrane, nucleoplasm.