Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLCO1A2 (P46721) - Overview - Molecular Target Synopsis

Protein


SLCO1A2, Solute carrier organic anion transporter family member 1A2
UniProt P46721

Also Known as SO1A2_HUMAN, SLCO1A2, OATP, OATP1, OATP1A2, SLC21A3

Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLCO1A2 is active in the following subcellular-locations: cell membrane.
GO terms: SLCO1A2 is active in the following subcellular-locations: integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLCO1A2 has gain in 14 cell-lines, loss in 4 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, MCF7, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVISE, NCI-H1623, UMC-11

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SLCO1A2 has been screened with 57 compounds (96 bioactivities). (see details)