Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BDP1 (P46678) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 10/09/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 10/09/2019)


Chains assessed9
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria9


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6F40_W Transcription factor TFIIIB component B'' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 60.6 70.4 Yes No
2 empty 1.98 59.1 38.5 No No
3 empty 2.44 63.7 17.6 No No
4 empty 2.05 79 17.7 No No
5 empty 1.78 67.6 9.2 No No
6 empty 2.32 53.6 14.3 No No
7 empty 1.66 74.3 10.3 No No
8 empty 2.3 46.4 14.8 No No
9 empty 2.45 55.4 12.2 No No
10 empty 2.11 60.9 7.1 No No
6CND_S Transcription factor TFIIIB component B'' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 57.8 41.9 Yes No
2 empty 2.03 52.6 26.4 No No
3 empty 2.37 60.7 24.4 No No
4 empty 2.07 59.9 19.3 No No
5 empty 1.79 42 16.1 No No
6 empty 1.5 71.5 16.5 No No
7 empty 2.23 46.2 14.2 No No
8 empty 2.25 47.5 14.1 No No
9 empty 2.59 53.9 14.8 No No
10 empty 2.06 56.6 12.4 No No
6F44_W Transcription factor TFIIIB component B'' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 62 54.5 Yes No
2 empty 2 60 42.2 No No
3 empty 2.04 68.8 25 No No
4 empty 1.99 55 18.1 No No
5 empty 1.74 77.9 17.3 No No
6 empty 1.8 64.8 12.8 No No
7 empty 1.87 98.2 0 Yes No
8 empty 2.54 53.9 13.8 No No
9 empty 2.37 59 13.6 No No
10 empty 2.45 56.9 12.9 No No
6CNC_S Transcription factor TFIIIB component B'' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 61.9 30.4 Yes No
2 empty 2.04 54.5 25.8 No No
3 empty 2.08 62.1 20.4 No No
4 empty 2.02 62.4 19.9 No No
5 empty 2.2 62 17.6 No No
6 empty 1.8 41.4 18.5 No No
7 empty 2.21 42.8 16.8 No No
8 empty 2.05 45.1 12.3 No No
9 empty 2.37 48.5 14.1 No No
10 empty 1.05 67.1 12.6 No No
6F41_W Transcription factor TFIIIB component B'' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 61.9 52.2 Yes No
2 empty 2.13 61.2 42.3 No No
3 empty 2 75.1 24.4 No No
4 empty 2.31 58.9 16.8 No No
5 empty 1.93 54.1 18 No No
6 empty 1.81 66.4 13.2 No No
7 empty 1.77 69.5 8.5 No No
8 empty 2.53 49.2 13.8 No No
9 empty 2.33 59.2 9 No No
10 empty 2.18 56.5 11.3 No No
6CNF_S Transcription factor TFIIIB component B'' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 59.4 32.9 Yes No
2 empty 1.87 52.7 24.4 No No
3 empty 1.74 62.7 20.8 No No
4 empty 2.32 60 16.1 No No
5 empty 1.7 41.7 16.2 No No
6 empty 2.22 43.7 17 No No
7 empty 1.99 45.1 13.1 No No
8 empty 2.15 51.2 11.4 No No
9 empty 2.31 52 13.8 No No
10 empty 2.24 57 14.3 No No
6F42_W Transcription factor TFIIIB component B'' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 61.2 54.8 Yes No
2 empty 2.06 60.3 40.4 No No
3 empty 2.01 66.4 21.8 No No
4 empty 1.99 53.6 18.4 No No
5 empty 1.93 78.5 17.1 No No
6 empty 1.73 68.4 8.2 No No
7 empty 2.17 52.1 15.3 No No
8 empty 1.91 74.2 8.1 No No
9 empty 2.07 47.7 9.8 No No
10 empty 2.23 56.3 7.9 No No
6CNB_S Transcription factor TFIIIB component B'' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 59.7 37.8 Yes No
2 empty 2.07 52.6 25.8 No No
3 empty 2.11 64.4 20.8 No No
4 empty 1.75 42.2 21.1 No No
5 empty 2.11 61.9 17.8 No No
6 empty 2.26 45.9 16.7 No No
7 empty 1.74 70.9 10 No No
8 empty 2.33 51.8 14.2 No No
9 empty 2.41 59.3 13 No No
10 empty 2.05 54.4 12.4 No No
6EU0_V Transcription factor TFIIIB component B'' Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.39 64.3 33.3 Yes No
2 empty 2.11 70.2 38 No No
3 empty 2.3 56.9 25.2 No No
4 empty 2.2 73.5 31.8 No No
5 empty 2.55 58 24.2 No No
6 empty 2.63 53 21.5 No No
7 empty 1.76 68.6 18.1 No No
8 empty 2.78 58.6 21.5 No No
9 empty 2.2 64.4 21.2 No No
10 empty 1.84 68.8 10.1 No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score