Molecular Target Synopsis
Overview
Domains and Structures
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Chemistry
Ligand Efficiency Plot
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RPA43 (P46669) - Overview - Molecular Target Synopsis

Protein


RPA43, DNA-directed RNA polymerase I subunit RPA43
UniProt P46669

Also Known as RPA43_YEAST, RPA43, RRN12

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. Through its association with RRN3 is involved in recruitment of Pol I to rDNA promoters. In vitro, the A13-A43 subcomplex binds single-stranded RNA. Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Interacts with RPO26/ABC23 and with the initiation factor RRN3.

6HLR
YEAST RNA POLYMERASE I ELONGATION COMPLEX BOUND TO NUCLEOTIDE ANALOG GMPCPP (CORE FOCUSED)
RCSB/PDB
Inspect Structure
See all 3D Structures for RPA43

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
326P46669-1

Sub-cellular localization


UniProt: RPA43 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: RPA43 is active in the following subcellular-locations: RNA polymerase I complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RPA43 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RPA43 there are:
28 structures (33 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis