Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ASMT (P46597) - Overview - Molecular Target Synopsis

Protein


ASMT, Acetylserotonin O-methyltransferase
Enzyme Classification 2.1.1.4
UniProt P46597

Also Known as ASMT_HUMAN, ASMT

Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. Homodimer.

4A6E
CRYSTAL STRUCTURE OF HUMAN N-ACETYLSEROTONIN METHYLTRANSFERASE (ASMT) IN COMPLEX WITH SAM AND N-ACETYLSEROTONIN
RCSB/PDB
Inspect Structure
See all 3D Structures for ASMT

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: ASMT is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ASMT has gain in 2 cell-lines, loss in 40 cell-lines and no signal in 962 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TMD8, OCI-LY-3, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For ASMT there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ASMT has been screened with compounds ( bioactivities). (see details)