Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTM5 (P46439) - Overview - Molecular Target Synopsis

Protein


GSTM5, Glutathione S-transferase Mu 5
Enzyme Classification 2.5.1.18
UniProt P46439

Also Known as GSTM5_HUMAN, GSTM5

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Homodimer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GSTM5 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTM5 is active in the following subcellular-locations: cytosol, intercellular bridge.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTM5 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, LOXIMVI, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 675.T, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, HMEC

(see details)

3D Structures


At greater than 75% identity similarity to GSTM5 there are:
34 structures (94 chains) solved
27 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

GSTM5 is solved in complex with the approved drug(s):

GDS/OXIGLUTATIONE (1YKC_A, 1YKC_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTM5 has been screened with 1 compounds (1 bioactivities). (see details)