HTR3A (P46098) - Overview - Molecular Target Synopsis
HTR3A, 5-hydroxytryptamine receptor 3A
Also Known as 5HT3A_HUMAN, HTR3A, 5HT3R, HTR3
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: HTR3A is active in the following subcellular-locations: cell junction, cell membrane, postsynaptic cell membrane, synapse.
GO terms: HTR3A is active in the following subcellular-locations: axon, cell junction, cleavage furrow, cytoplasm, glutamatergic synapse, integral component of plasma membrane, integral component of postsynaptic membrane, integral component of presynaptic membrane, neuron projection, neuronal cell body, plasma membrane, serotonin-activated cation-selective channel complex, synapse.