Molecular Target Synopsis
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Domains and Structures
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MAP2K4 (P45985) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - 4LG4_A 35.23 2.0E-39 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3EQD_A 36.2 2.0E-54 AGS
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3ZLW_A 36.28 1.0E-52 MT8
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - 4LG4_C 35.23 2.0E-39 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3EQB_A 36.2 2.0E-54 LUG ATP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3MBL_A 36.28 2.0E-53 LSG ADP
Protein kinase domain (100%) (view alignment) MAP2K4 (P45985) - 3ALN_C 100 0 ANP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) BRAF (P15056) 4MNE_D 36.2 2.0E-54 ACP 573
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3ZM4_A 36.28 2.0E-53 22T
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - 4LG4_F 35.23 2.0E-39 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3VVH_A 36.2 2.0E-54 4BM ATP
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - 5Z1E_A 52.72 8.0E-82 95U
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - 5Y90_A 51.49 7.0E-82 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3V01_A 36.2 2.0E-54 3V0 ATP
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) CAB39 (Q9Y376) 4O27_B 35.07 2.0E-36 ADP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 5BX0_A 36.28 2.0E-53 4W5
Protein kinase domain (100%) (view alignment) MAP2K1 (P29678) KSR2 (Q6VAB6) 2Y4I_C 36.2 6.0E-55 ATP
Protein kinase domain (100%) (view alignment) MAP2K4 (P45985) - 3ALN_A 100 0 ANP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3W8Q_A 36.28 2.0E-53 AGS
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - 5B2K_A 51.16 3.0E-81 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3ZLS_A 36.28 2.0E-53 92P
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) BRAF (P15056) 4MNE_E 36.2 2.0E-54 ACP 573
Protein kinase domain (100%) (view alignment) MAP2K4 (P45985) - 3ALN_B 100 0 ANP
Protein kinase domain (99%) (view alignment) STK3 (Q13188) SAV1 (Q9H4B6) 6AO5_A 35.61 1.0E-39 ANP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3EQG_A 36.2 2.0E-54 4BM ADP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3EQH_A 36.2 2.0E-54 ADP 5BM
Protein kinase domain (100%) (view alignment) MAP2K1 (P29678) KSR2 (Q6VAB6) 5KKR_C 36.2 8.0E-55 -
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - 3WZU_A 51.16 3.0E-81 1FM
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3ORN_A 40 4.0E-58 ANP PGE 3OR
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3E8N_A 36.2 2.0E-54 VRA ATP
Protein kinase domain (100%) (view alignment) MAP2K6 (P52564) - 3ENM_C 57.34 6.0E-100 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) BRAF (P15056) 4MNE_H 36.2 2.0E-54 ACP 573
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - 4LG4_D 35.23 2.0E-39 -
Protein kinase domain (100%) (view alignment) STK3 (Q13188) RASSF5 (Q8WWW0) 4LGD_B 35.19 7.0E-40 ANP
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - 5Z1D_A 52.04 4.0E-80 EPE 95U
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3SLS_B 40.69 2.0E-57 77D ANP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 5YT3_C 35.98 2.0E-52 ANP
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - 5Y8U_A 50.83 4.0E-80 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 4U80_A 36.2 2.0E-54 ANP 3EX
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 2P55_A 36.2 2.0E-54 MRA ATP
Protein kinase domain (100%) (view alignment) MAP2K4 (P45985) - 3VUT_B 100 0 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) BRAF (P15056) 4MNE_A 36.2 2.0E-54 ACP 573
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 4AN2_A 40.88 1.0E-58 ACP EUI
Protein kinase domain (100%) (view alignment) STK3 (Q13188) RASSF5 (Q8WWW0) 4LGD_A 35.19 7.0E-40 ANP
Protein kinase domain (100%) (view alignment) MAP2K2 (P36507) - 1S9I_B 37.24 7.0E-56 5EA ATP
Protein kinase domain (100%) (view alignment) MAP2K4 (P45985) - 3ALO_A 100 0 ANP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3EQF_A 36.2 2.0E-54 KSA
Protein kinase domain (100%) (view alignment) MAP2K6 (P52564) - 3VN9_A 58.36 1.0E-101 ANK
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - 3CKW_A 35.07 2.0E-36 -
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) CAB39L (Q9H9S4) 3ZHP_C 35.19 3.0E-36 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 5EYM_A 36.2 2.0E-54 5U5
Protein kinase domain (100%) (view alignment) STK3 (Q13188) RASSF5 (Q8WWW0) 4LGD_C 35.19 7.0E-40 ANP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 4U7Z_A 36.2 2.0E-54 ANP 3EW
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - 4LG4_E 35.23 2.0E-39 -
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) CAB39L (Q9H9S4) 3ZHP_D 35.19 3.0E-36 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3WIG_A 40 4.0E-58 CHU ANP
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - 6IB0_A 50.32 7.0E-82 H8Z
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 5YT3_B 35.98 2.0E-52 ANP
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - 5B2M_A 51.16 3.0E-81 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 5YT3_A 35.98 2.0E-52 ANP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3PP1_A 36.28 2.0E-53 IZG ATP
Protein kinase domain (100%) (view alignment) STK3 (Q13188) RASSF5 (Q8WWW0) 4LGD_D 35.19 7.0E-40 ANP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 4AN9_A 40.88 1.0E-58 2P7 ACP
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - 2DYL_A 49.84 5.0E-81 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3SLS_A 40.69 2.0E-57 77D ANP
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - 3CKX_A 35.07 2.0E-36 STU
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 4ARK_A 36.2 2.0E-54 M3K ADP
Protein kinase domain (100%) (view alignment) MAP2K2 (P36507) - 1S9I_A 37.24 7.0E-56 5EA ATP
Protein kinase domain (100%) (view alignment) MAP2K6 (P52564) - 3FME_A 58.54 3.0E-99 STU
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 5HZE_A 36.59 2.0E-53 E62
Protein kinase domain (100%) (view alignment) MAP2K6 (P52564) - 3ENM_B 57.34 6.0E-100 -
Protein kinase domain (100%) (view alignment) MAP2K6 (P52564) - 3ENM_D 57.34 6.0E-100 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 4U81_A 36.2 2.0E-54 ANP 3EY
Protein kinase domain (100%) (view alignment) MAP2K6 (P52564) - 3ENM_A 57.34 6.0E-100 -
Protein kinase domain (100%) (view alignment) MAP2K4 (P45985) - 3VUT_A 100 0 -
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - 5B2L_A 52.72 8.0E-82 EPE
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 4LMN_A 36.2 2.0E-54 ANP EUI
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3EQC_A 36.2 2.0E-54 AGS 3BM
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3ZLY_A 36.28 2.0E-53 YSO
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 1S9J_A 36.2 2.0E-54 BBM ATP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3DV3_A 36.28 2.0E-53 MEK ATP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 4AN3_A 40.88 1.0E-58 5Y0 ATP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3EQI_A 36.2 2.0E-54 ADP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3ZLX_A 36.28 2.0E-53 5EZ
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 4ANB_A 40.88 1.0E-58 ACP YQY
Protein kinase domain (99%) (view alignment) STK4 (Q13043) - 3COM_B 35.23 1.0E-39 -
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3VVH_B 36.2 2.0E-54 4BM ATP
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - 6IB2_A 50.63 2.0E-82 862
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 5EYM_B 36.2 2.0E-54 5U5
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3V04_A 36.2 2.0E-54 V04 ATP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3OS3_A 40 4.0E-58 3OS ATP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3VVH_C 36.2 2.0E-54 4BM ATP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 5YT3_D 35.98 2.0E-52 ANP
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3DY7_A 36.2 2.0E-54 1CX ATP
Protein kinase domain (99%) (view alignment) STK4 (Q13043) - 3COM_A 35.23 1.0E-39 -
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - 4LG4_B 35.23 2.0E-39 -