Molecular Target Synopsis
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MAP2K4 (P45985) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 4LG4_A 35.23 2.0E-39 2.415Å - 2013-09-18
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3EQD_A 36.2 2.0E-54 2.1Å AGS 2009-02-24
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 4LG4_C 35.23 2.0E-39 2.415Å - 2013-09-18
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3ZLW_A 36.28 1.0E-52 2.12Å MT8 2013-05-22
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3EQB_A 36.2 2.0E-54 2.6Å LUG ATP 2008-11-11
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3MBL_A 36.28 2.0E-53 2.6Å LSG ADP 2010-07-28
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) BRAF (P15056) HUMAN 4MNE_D 36.2 2.0E-54 2.848Å ACP 573 2014-06-18
Protein kinase domain (100%) (view alignment) MAP2K4 (P45985) - HUMAN 3ALN_C 100 0 2.3Å ANP 2010-10-27
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3ZM4_A 36.28 2.0E-53 2.37Å 22T 2013-05-22
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3VVH_A 36.2 2.0E-54 2Å 4BM ATP 2013-08-28
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 4LG4_F 35.23 2.0E-39 2.415Å - 2013-09-18
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 5Z1E_A 52.72 8.0E-82 2.3Å 95U 2019-01-02
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 5Y90_A 51.49 7.0E-82 1.3Å - 2017-10-11
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 6QFT_A 50.32 7.0E-82 2.7Å J0B 2019-05-22
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3V01_A 36.2 2.0E-54 2.7Å 3V0 ATP 2012-05-09
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) CAB39 (Q9Y376) HUMAN 4O27_B 35.07 2.0E-36 3.185Å ADP 2014-12-03
Protein kinase domain (100%) (view alignment) MAP2K1 (P29678) KSR2 (Q6VAB6) RABBIT 2Y4I_C 36.2 6.0E-55 3.45Å ATP 2011-01-19
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 5BX0_A 36.28 2.0E-53 2.93Å 4W5 2015-12-23
Protein kinase domain (100%) (view alignment) MAP2K4 (P45985) - HUMAN 3ALN_A 100 0 2.3Å ANP 2010-10-27
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3W8Q_A 36.28 2.0E-53 2.2Å AGS 2014-03-26
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 5B2K_A 51.16 3.0E-81 2.75Å - 2016-04-06
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3ZLS_A 36.28 2.0E-53 2.5Å 92P 2013-05-22
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) BRAF (P15056) HUMAN 4MNE_E 36.2 2.0E-54 2.848Å ACP 573 2014-06-18
Protein kinase domain (100%) (view alignment) MAP2K4 (P45985) - HUMAN 3ALN_B 100 0 2.3Å ANP 2010-10-27
Protein kinase domain (99%) (view alignment) STK3 (Q13188) SAV1 (Q9H4B6) HUMAN 6AO5_A 35.61 1.0E-39 2.95Å ANP 2017-11-08
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3EQG_A 36.2 2.0E-54 2.5Å 4BM ADP 2009-02-24
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3EQH_A 36.2 2.0E-54 2Å ADP 5BM 2009-02-24
Protein kinase domain (100%) (view alignment) MAP2K1 (P29678) KSR2 (Q6VAB6) RABBIT 5KKR_C 36.2 8.0E-55 3.5Å - 2016-08-31
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 3WZU_A 51.16 3.0E-81 3Å 1FM 2015-01-14
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3ORN_A 40 4.0E-58 2.8Å ANP PGE 3OR 2011-03-02
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3E8N_A 36.2 2.0E-54 2.5Å VRA ATP 2009-09-01
Protein kinase domain (100%) (view alignment) MAP2K6 (P52564) - HUMAN 3ENM_C 57.34 6.0E-100 2.3Å - 2009-03-03
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) BRAF (P15056) HUMAN 4MNE_H 36.2 2.0E-54 2.848Å ACP 573 2014-06-18
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 4LG4_D 35.23 2.0E-39 2.415Å - 2013-09-18
Protein kinase domain (100%) (view alignment) STK3 (Q13188) RASSF5 (Q8WWW0) HUMAN 4LGD_B 35.19 7.0E-40 3.05Å ANP 2013-09-18
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 5Z1D_A 52.04 4.0E-80 2.28Å EPE 95U 2019-01-02
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3SLS_B 40.69 2.0E-57 2.3Å 77D ANP 2012-02-29
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 5YT3_C 35.98 2.0E-52 2.9Å ANP 2018-11-21
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 5Y8U_A 50.83 4.0E-80 2.92Å - 2017-10-11
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 4U80_A 36.2 2.0E-54 2.8Å ANP 3EX 2014-09-24
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 2P55_A 36.2 2.0E-54 2.8Å MRA ATP 2007-10-02
Protein kinase domain (100%) (view alignment) MAP2K4 (P45985) - HUMAN 3VUT_B 100 0 3.5Å - 2012-09-05
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) BRAF (P15056) HUMAN 4MNE_A 36.2 2.0E-54 2.848Å ACP 573 2014-06-18
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 4AN2_A 40.88 1.0E-58 2.5Å ACP EUI 2012-12-19
Protein kinase domain (100%) (view alignment) STK3 (Q13188) RASSF5 (Q8WWW0) HUMAN 4LGD_A 35.19 7.0E-40 3.05Å ANP 2013-09-18
Protein kinase domain (100%) (view alignment) MAP2K2 (P36507) - HUMAN 1S9I_B 37.24 7.0E-56 3.2Å 5EA ATP 2004-11-23
Protein kinase domain (100%) (view alignment) MAP2K4 (P45985) - HUMAN 3ALO_A 100 0 2.6Å ANP 2010-10-27
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3EQF_A 36.2 2.0E-54 2.7Å KSA 2009-02-24
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 5EYM_A 36.2 2.0E-54 2.7Å 5U5 2016-08-17
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) CAB39L (Q9H9S4) HUMAN 3ZHP_C 35.19 3.0E-36 2.9Å - 2013-01-16
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 3CKW_A 35.07 2.0E-36 1.96Å - 2008-04-29
Protein kinase domain (100%) (view alignment) MAP2K6 (P52564) - HUMAN 3VN9_A 58.36 1.0E-101 2.6Å ANK 2012-02-29
Protein kinase domain (100%) (view alignment) STK3 (Q13188) RASSF5 (Q8WWW0) HUMAN 4LGD_C 35.19 7.0E-40 3.05Å ANP 2013-09-18
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 4U7Z_A 36.2 2.0E-54 2.7Å ANP 3EW 2014-09-24
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 4LG4_E 35.23 2.0E-39 2.415Å - 2013-09-18
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) CAB39L (Q9H9S4) HUMAN 3ZHP_D 35.19 3.0E-36 2.9Å - 2013-01-16
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3WIG_A 40 4.0E-58 2.45Å CHU ANP 2014-06-04
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 6QG4_A 50.32 7.0E-82 2.3Å J0E 2019-05-22
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 6IB0_A 50.32 7.0E-82 2.6Å H8Z 2019-02-27
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 5YT3_B 35.98 2.0E-52 2.9Å ANP 2018-11-21
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 5B2M_A 51.16 3.0E-81 3.05Å - 2016-04-06
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 5YT3_A 35.98 2.0E-52 2.9Å ANP 2018-11-21
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3PP1_A 36.28 2.0E-53 2.7Å IZG ATP 2011-02-23
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 6QG7_A 50.32 7.0E-82 2Å 6HL 2019-05-22
Protein kinase domain (100%) (view alignment) STK3 (Q13188) RASSF5 (Q8WWW0) HUMAN 4LGD_D 35.19 7.0E-40 3.05Å ANP 2013-09-18
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 4AN9_A 40.88 1.0E-58 2.8Å 2P7 ACP 2012-12-19
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 2DYL_A 49.84 5.0E-81 2.45Å - 2007-08-28
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3SLS_A 40.69 2.0E-57 2.3Å 77D ANP 2012-02-29
Protein kinase domain (99%) (view alignment) STK24 (Q9Y6E0) - HUMAN 3CKX_A 35.07 2.0E-36 2.7Å STU 2008-04-29
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 4ARK_A 36.2 2.0E-54 2.6Å M3K ADP 2013-03-06
Protein kinase domain (100%) (view alignment) MAP2K2 (P36507) - HUMAN 1S9I_A 37.24 7.0E-56 3.2Å 5EA ATP 2004-11-23
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 6QFL_A 50.32 7.0E-82 2.2Å - 2019-05-22
Protein kinase domain (100%) (view alignment) MAP2K6 (P52564) - HUMAN 3FME_A 58.54 3.0E-99 2.26Å STU 2009-01-06
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 5HZE_A 36.59 2.0E-53 2.4Å E62 2017-05-03
Protein kinase domain (100%) (view alignment) MAP2K6 (P52564) - HUMAN 3ENM_B 57.34 6.0E-100 2.3Å - 2009-03-03
Protein kinase domain (100%) (view alignment) MAP2K6 (P52564) - HUMAN 3ENM_D 57.34 6.0E-100 2.3Å - 2009-03-03
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 4U81_A 36.2 2.0E-54 2.7Å ANP 3EY 2014-09-24
Protein kinase domain (100%) (view alignment) MAP2K6 (P52564) - HUMAN 3ENM_A 57.34 6.0E-100 2.3Å - 2009-03-03
Protein kinase domain (100%) (view alignment) MAP2K4 (P45985) - HUMAN 3VUT_A 100 0 3.5Å - 2012-09-05
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 5B2L_A 52.72 8.0E-82 2.1Å EPE 2016-04-06
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 4LMN_A 36.2 2.0E-54 2.8Å ANP EUI 2013-08-07
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3EQC_A 36.2 2.0E-54 1.8Å AGS 3BM 2009-02-24
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3ZLY_A 36.28 2.0E-53 2.11Å YSO 2013-05-22
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 1S9J_A 36.2 2.0E-54 2.4Å BBM ATP 2004-11-23
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3DV3_A 36.28 2.0E-53 2.25Å MEK ATP 2009-07-21
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3EQI_A 36.2 2.0E-54 1.9Å ADP 2009-02-24
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 4AN3_A 40.88 1.0E-58 2.1Å 5Y0 ATP 2012-12-19
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3ZLX_A 36.28 2.0E-53 2.2Å 5EZ 2013-05-22
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 4ANB_A 40.88 1.0E-58 2.2Å ACP YQY 2012-12-19
Protein kinase domain (99%) (view alignment) STK4 (Q13043) - HUMAN 3COM_B 35.23 1.0E-39 2.2Å - 2008-04-15
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3VVH_B 36.2 2.0E-54 2Å 4BM ATP 2013-08-28
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 6IB2_A 50.63 2.0E-82 2.1Å 862 2019-02-27
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 6QFR_A 50.32 7.0E-82 2.3Å - 2019-05-22
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 5EYM_B 36.2 2.0E-54 2.7Å 5U5 2016-08-17
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 6QHO_A 50.32 7.0E-82 2.7Å J3H 2019-05-22
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3V04_A 36.2 2.0E-54 2.7Å V04 ATP 2012-05-09
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - 3OS3_A 40 4.0E-58 2.77Å 3OS ATP 2011-07-27
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3VVH_C 36.2 2.0E-54 2Å 4BM ATP 2013-08-28
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 5YT3_D 35.98 2.0E-52 2.9Å ANP 2018-11-21
Protein kinase domain (100%) (view alignment) MAP2K7 (O14733) - HUMAN 6QHR_A 50.32 7.0E-82 2.4Å J3N 2019-05-22
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) - HUMAN 3DY7_A 36.2 2.0E-54 2.7Å 1CX ATP 2009-06-16
Protein kinase domain (99%) (view alignment) STK4 (Q13043) - HUMAN 3COM_A 35.23 1.0E-39 2.2Å - 2008-04-15
Protein kinase domain (100%) (view alignment) MAP2K1 (Q02750) BRAF (P15056) HUMAN 6U2G_A 36.2 9.0E-55 2.886Å ACP 2019-08-28
Protein kinase domain (99%) (view alignment) STK3 (Q13188) - HUMAN 4LG4_B 35.23 2.0E-39 2.415Å - 2013-09-18