Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAP2K4 (P45985) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed6
Chains with at least one site assessed as druggable using the strict criteria3
Chains with at least one site assessed as druggable using the relaxed criteria6


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3ALN_C Dual specificity mitogen-activated protein kinase kinase 4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 62.4 35.8 Yes No
2 empty 2.13 62.6 34 No No
3 empty 1.83 73.5 25.1 No No
4 empty 2.44 62.6 22.6 No No
5 empty 1.99 60.5 14.8 No No
6 empty 1.86 73.4 9.1 No No
7 empty 2.25 52.2 11.3 No No
8 empty 2.13 77.6 7.7 No No
9 empty 2.49 75.5 8.9 No No
10 empty 2.1 67.7 7.1 No No
3ALO_A Dual specificity mitogen-activated protein kinase kinase 4 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 68.8 47.8 Yes Yes
2 empty 2.33 65.4 27.3 No No
3 empty 2.05 61.3 27.5 No No
4 empty 2.18 64.5 25.1 No No
5 empty 2.35 60.8 17.2 No No
6 empty 2.01 51.6 15.5 No No
7 empty 2.37 61 18 No No
8 empty 2.31 53.7 13.4 No No
9 empty 2.32 56 15 No No
10 empty 2.77 62.6 20.2 No No
3VUT_A Dual specificity mitogen-activated protein kinase kinase 4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 66 40.3 Yes No
2 empty 1.83 67.1 27.7 No No
3 empty 2.11 67.4 20.1 No No
4 empty 1.73 72.4 15.9 No No
5 empty 1.9 65.2 19.5 No No
6 empty 2.24 64.6 21.5 No No
7 empty 2.36 63.3 19.7 No No
8 empty 2.56 59.7 10.7 No No
9 empty 2.55 57.3 10.4 No No
10 empty 1.87 58.2 10.5 No No
3ALN_A Dual specificity mitogen-activated protein kinase kinase 4 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 70.4 42.2 Yes Yes
2 empty 2.43 66 43.5 No No
3 empty 2 60.5 25 No No
4 empty 2.46 60.8 18.5 No No
5 empty 2.1 67.5 14.2 No No
6 empty 2.36 70 13.2 No No
7 empty 2.4 62.4 19.9 No No
8 empty 2.15 51 11.7 No No
9 empty 2.5 66.2 6.5 No No
10 empty 2.37 81.3 8.1 No No
3ALN_B Dual specificity mitogen-activated protein kinase kinase 4 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 65.3 59.1 Yes No
2 empty 2.27 66.5 21.4 No No
3 empty 1.98 68 15.4 No No
4 empty 2.3 53.4 15.9 No No
5 empty 1.81 67.8 14.1 No No
6 empty 2.36 57.5 16.8 No No
7 empty 2.07 57.1 10.9 No No
8 empty 2.1 58.7 15.4 No No
9 empty 2.13 63.7 10.3 No No
10 empty 2.54 62.5 12.8 No No
3VUT_B Dual specificity mitogen-activated protein kinase kinase 4 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 69.3 48.8 Yes Yes
2 empty 2.22 72.6 34.2 No No
3 empty 2.13 68.8 37.1 No No
4 empty 1.78 70.1 21 No No
5 empty 2.49 69 14.6 No No
6 empty 1.96 70.9 10.3 No No
7 empty 2.12 86.3 8.7 Yes No
8 empty 2.08 56.8 8.5 No No
9 empty 2.15 64.7 11.5 No No
10 empty 1.1 96.2 0 Yes No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria2
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3ALN_A (3610275) Dual specificity mitogen-activated protein kinase kinase 4 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.3Å Yes Yes
3ALO_A (3610278) Dual specificity mitogen-activated protein kinase kinase 4 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.6Å Yes Yes
Ligand-based Druggability Score: -0.1
Ligand-based Druggability Score Percentile: 78%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


MAP2K4 is involved in 43 interactions in the network.


Druggability
Overall Druggability Percentile: 79.90
Druggability for Cancer Therapeutics: 93.92
Druggability for Other Therapeutics: 59.63
Cancer-Associated
Cancer-associated percentile : 96.73
Network Articulation Point
Is MAP2K4 critical for communication in the network?


Detailed Graph Legend:Help