Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
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Germline Genetics

MAPK8 (P45983) - Pathways - Molecular Target Synopsis

Data acquired from 72 pathway associations found
Pathway Name Source
Activation of BIM and translocation to mitochondriaReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Activation of BMF and translocation to mitochondriaReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Activation of the AP-1 family of transcription factorsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
DSCAM interactionsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
FCERI mediated MAPK activationReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Interleukin-38 signalingReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
NRAGE signals death through JNKReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
NRIF signals cell death from the nucleusReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Oxidative Stress Induced SenescenceReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Alzheimer disease-amyloid secretase pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
AngiogenesisPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
Apoptosis signaling pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
B cell activationPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
BCRNetPath 12/2011
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
EGF receptor signaling pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
EGFR1NetPath 12/2011
ERK cascade ( CD4 T cell receptor signaling (ERK cascade) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
FAS signaling pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
Fas signaling pathway ( Fas signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
FGF signaling pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
Gastrin_CCK2R_240212PANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
IL-1 signaling pathwaywikipathways
IL-3 Signaling Pathwaywikipathways
IL1NetPath 12/2011
IL2NetPath 12/2011
IL3NetPath 12/2011
IL4NetPath 12/2011
IL6NetPath 12/2011
Integrin signaling pathway ( Integrin signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Integrin signalling pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
Interferon-gamma signaling pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
JNK cascade ( CD4 T cell receptor signaling (JNK cascade) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
JNK cascade ( CD4 T cell receptor signaling )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
JNK cascade ( EGF signaling pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
JNK cascade ( IL-1 signaling pathway (through JNK cascade) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
JNK cascade ( IL-1 signaling pathway (through JNK cascade) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
JNK cascade ( IL-1 signaling pathway (through JNK cascade) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
JNK cascade ( PDGF signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
JNK cascade ( PDGF signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
JNK cascade ( TGF-beta signaling(through TAK1) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
JNK cascade ( TNFR1 signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
JNK cascade ( TNFR1 signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
JNK cascade ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
JNK cascade ( Toll-like receptor signaling pathway (through JNK cascade) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
JNK cascade ( Toll-like receptor signaling pathway (through JNK cascade) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
KitReceptorNetPath 12/2011
LeptinNetPath 12/2011
Negative regulation of (nuclear import of R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Oxidative stress responsePANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
p38 cascade ( IL-1 signaling pathway (through p38 cascade) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
p38 cascade ( IL-1 signaling pathway (through p38 cascade) )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Parkinson diseasePANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
PDGF signaling pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
ProlactinNetPath 12/2011
RANKLNetPath 12/2011
Ras PathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
T cell activationPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
TCRNetPath 12/2011
TGF-beta signaling pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
TGF_beta_ReceptorNetPath 12/2011
TNFalphaNetPath 12/2011
Toll receptor signaling pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
TSLPNetPath 12/2011
TWEAKNetPath 12/2011
VEGF signaling pathway ( VEGF signaling pathway )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
WntNetPath 12/2011