Molecular Target Synopsis
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MAPK8 (P45983) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed46
Chains with at least one site assessed as druggable using the strict criteria38
Chains with at least one site assessed as druggable using the relaxed criteria45


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3VUH_A Mitogen-activated protein kinase 8 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 63.6 20.1 No No
2 empty 1.98 74.3 20.5 No No
3 empty 2.25 53 23.8 No No
4 bound 2.24 60.9 17.9 No No
5 empty 2.05 70.6 13.5 No No
6 empty 2.23 61.6 13.9 No No
7 empty 2.3 70.2 13.1 No No
8 bound 2.15 58.1 19.6 No No
9 empty 1.94 68.8 12 No No
10 empty 1.77 69.8 10.4 No No
5LW1_E Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 79.4 23.1 Yes Yes
2 empty 2.18 56.6 25 No No
3 empty 2.13 64.9 22.7 No No
4 empty 2.06 60.3 19.8 No No
5 bound 1.89 64.7 14.8 No No
6 empty 1.49 63.9 18.4 No No
7 empty 2.21 67.7 15.3 No No
8 empty 1.83 52.9 15.7 No No
9 empty 2.36 56.7 17.1 No No
10 empty 1.99 62.4 11.3 No No
3V3V_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.25 69.2 49.5 Yes Yes
2 bound 1.91 72.7 30.6 No No
3 empty 2.22 66.3 30.9 No No
4 empty 2.17 71.3 20.6 No No
5 empty 2.26 73.6 14.9 No No
6 bound 2.11 68.3 19.4 No No
7 empty 2.04 70.3 12.7 No No
8 empty 2.27 72.5 13.5 No No
9 empty 2.25 67.2 10.9 No No
10 empty 2.25 64.4 13.4 No No
3O17_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 70 43.9 Yes Yes
2 empty 2.09 68 32.6 No No
3 bound 2.11 76 18.6 No No
4 bound 1.77 69.5 17.3 No No
5 empty 2.25 65.1 17.4 No No
6 empty 1.77 58.2 19.1 No No
7 empty 2 69.4 10.2 No No
8 empty 2.27 64 12.9 No No
9 empty 2.18 69.9 9.2 No No
10 empty 1.97 76.7 13.1 No No
4UX9_A Mitogen-activated protein kinase 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 64.6 36.1 Yes No
2 bound 2 70.5 24.8 No No
3 empty 2.25 61.4 21.6 No No
4 empty 1.5 57.1 16.9 No No
5 empty 2.22 64.3 12.6 No No
6 empty 2.28 75.7 12.7 No No
7 empty 2.13 77.5 11.9 No No
8 empty 2.39 62.5 12.3 No No
9 empty 2.24 60.8 14.7 No No
10 empty 2.14 62.4 19.9 No No
4YR8_A Mitogen-activated protein kinase 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 65 42.1 Yes No
2 empty 2.31 65.4 20.2 No No
3 empty 2.58 64.7 27.8 No No
4 empty 2.51 66.6 26.3 No No
5 empty 1.82 66.7 22 No No
6 empty 2.03 67.3 13.2 No No
7 empty 1.71 67.4 12.3 No No
8 empty 2.23 75.2 10.3 No No
9 empty 2.32 65.8 10.5 No No
10 empty 2.29 62.4 9.5 No No
4IZY_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 66.3 43.3 Yes Yes
2 empty 2.26 68.8 28.5 No No
3 empty 2.39 61.9 29.9 No No
4 empty 2.37 69.1 18.1 No No
5 empty 2.31 67.7 19.3 No No
6 empty 2.17 69 13.1 No No
7 empty 1.56 70 12.1 No No
8 empty 2.16 63 20.2 No No
9 empty 2.45 65.2 10.6 No No
10 empty 2.68 64.1 12.6 No No
3VUD_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 66.8 49 Yes Yes
2 empty 2.35 68.3 40.6 No No
3 empty 1.88 74.1 19.3 No No
4 empty 2.26 69.1 13.8 No No
5 empty 2.34 67 16.2 No No
6 empty 2.41 63.5 9.8 No No
7 empty 2.07 67.7 11.2 No No
8 empty 2.44 71.6 12.1 No No
9 empty 2.1 63.3 10.2 No No
10 empty 2.39 59.7 11.5 No No
4YR8_E Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 66.9 43.7 Yes Yes
2 empty 2.3 61.3 24.1 No No
3 empty 2.46 63 27.5 No No
4 empty 2.18 67 15.7 No No
5 empty 1.85 65.9 16.6 No No
6 empty 2.43 67.1 15.3 No No
7 empty 1.71 67.3 12.4 No No
8 empty 1.77 61.6 15.4 No No
9 empty 2.12 67.5 14.4 No No
10 empty 2.02 69.9 13.4 No No
4AWI_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 69.1 53.4 Yes Yes
2 empty 2.46 67.6 33.9 No No
3 empty 2.16 68.6 15.4 No No
4 empty 1.82 66.4 23 No No
5 bound 2.27 65.2 18.4 No No
6 empty 1.69 64.6 16.7 No No
7 empty 2.21 70.5 19 No No
8 empty 2.22 61.2 14.2 No No
9 empty 2.01 63.9 10.6 No No
10 empty 2.13 66.2 11.4 No No
2H96_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 68.7 34.7 Yes Yes
2 empty 2.36 57.3 29.4 No No
3 empty 2.22 59 22.2 No No
4 bound 2.34 70.9 15 No No
5 empty 1.61 53 17.4 No No
6 empty 2.01 58.3 18.2 No No
7 bound 1.42 71.1 14.1 No No
8 empty 2.37 70.9 12.9 No No
9 empty 2.06 62.3 14.2 No No
10 empty 2.09 51.7 13.2 No No
3O2M_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 67 26.3 Yes Yes
2 empty 2.2 58.6 21.4 No No
3 bound 1.49 64 21.2 No No
4 empty 1.99 63.5 19.6 No No
5 bound 1.89 68.7 18.3 No No
6 empty 1.74 60.3 15.4 No No
7 empty 2.21 65.3 15.7 No No
8 empty 2.16 58.3 16.6 No No
9 empty 1.5 61.1 15.6 No No
10 empty 1.68 65.8 12.3 No No
4HYU_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 68.6 42.3 Yes Yes
2 empty 2.6 60.8 31.4 No No
3 empty 2.47 66.2 25.3 No No
4 empty 1.65 71.9 21.1 No No
5 empty 2.12 72.4 21.9 No No
6 empty 2.11 66.6 21.1 No No
7 empty 1.5 66.9 11.8 No No
8 empty 2.22 67.9 16.1 No No
9 empty 2.27 63.2 14.1 No No
10 empty 2.43 69.4 10.1 No No
4HYS_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 68.8 42 Yes Yes
2 empty 2.41 65.8 24.7 No No
3 empty 2.01 70.1 27 No No
4 empty 2.25 69.9 23.4 No No
5 empty 1.96 64.4 15.7 No No
6 empty 2.07 79.7 11.5 No No
7 empty 1.8 70.6 12 No No
8 empty 2.21 73.9 8.7 No No
9 empty 2.42 65.2 10.3 No No
10 empty 2.54 58.1 12.7 No No
4E73_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 68.1 43.2 Yes Yes
2 empty 2.41 57.8 32.4 No No
3 empty 2.19 69.1 23.6 No No
4 empty 2.23 74.7 13.1 No No
5 empty 2.2 67.9 19.7 No No
6 empty 2.23 69.7 16.1 No No
7 empty 2.14 71.1 12 No No
8 empty 1.81 78.4 8.4 No No
9 empty 1.74 71.6 11.6 No No
10 empty 2.49 64.2 16.6 No No
2NO3_B Mitogen-activated protein kinase 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 70.7 29.7 Yes No
2 empty 2.32 55 26.8 No No
3 bound 2.2 83.9 18.3 No No
4 empty 1.64 71.3 14.7 No No
5 empty 2.02 66 17.3 No No
6 empty 1.57 60.5 15 No No
7 empty 2.23 67.2 15.6 No No
8 empty 2.09 62.8 16.7 No No
9 empty 1.63 64 14.1 No No
10 bound 2.19 53.4 15.7 No No
4QTD_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 76.7 36.2 Yes Yes
2 empty 2.14 61.3 24.4 No No
3 empty 2.12 64 26.4 No No
4 bound 1.74 62.6 17.8 No No
5 bound 1.62 65.2 21 No No
6 empty 2 54.6 20.2 No No
7 empty 1.78 60.5 14.2 No No
8 bound 1.87 62.1 17.3 No No
9 bound 1.87 65.3 12.4 No No
10 bound 2.11 60.6 17.4 No No
6F5E_B Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 67 47.2 Yes Yes
2 empty 2.21 66.4 25.6 No No
3 empty 2.11 64.2 26.8 No No
4 empty 1.72 65.5 19 No No
5 empty 1.87 59.3 20 No No
6 empty 2.28 71.1 15.2 No No
7 empty 2.2 66.7 13 No No
8 empty 2 71.6 10.9 No No
9 empty 2.51 60.9 13.5 No No
10 empty 2.26 60 13 No No
2H96_B Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.41 70 24.4 Yes Yes
2 bound 1.88 81.2 15.1 Yes Yes
3 empty 2.3 60.7 17.6 No No
4 empty 1.68 58.7 15.9 No No
5 bound 2.25 58.1 19.4 No No
6 bound 1.99 59.1 18.2 No No
7 empty 1.76 64.9 15.7 No No
8 empty 2.03 67.3 12.4 No No
9 empty 2.3 68.4 15.1 No No
10 empty 1.65 67.6 10.3 No No
4UX9_D Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 68.9 41 Yes Yes
2 bound 2.36 71.3 41.7 No No
3 empty 2.08 67.2 35.5 No No
4 empty 2.2 67.6 18.2 No No
5 empty 1.67 62.3 17.1 No No
6 empty 2.01 65 19.1 No No
7 empty 1.81 71.1 16.4 No No
8 empty 2.22 76.3 11.8 No No
9 empty 2 72.5 16.8 No No
10 empty 2.51 66.8 18.3 No No
3VUL_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 68.7 37 Yes Yes
2 empty 2.44 66 38.2 No No
3 empty 2.03 71.4 16.9 No No
4 empty 1.86 63.9 25.8 No No
5 empty 2.35 60.5 22 No No
6 empty 2.04 64.5 20.8 No No
7 empty 1.88 74.3 12.5 No No
8 empty 2.29 70.4 14.6 No No
9 empty 2.24 66.1 23.4 No No
10 empty 2.1 56.7 14.9 No No
5LW1_H Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 80.1 24.5 Yes Yes
2 empty 1.99 56.7 22.7 No No
3 bound 1.91 61.5 16 No No
4 empty 1.5 63.4 18.5 No No
5 empty 2.26 61.7 21.5 No No
6 empty 1.94 55.4 15.7 No No
7 empty 1.96 57.9 15.7 No No
8 empty 2.1 58.9 14.1 No No
9 empty 2.19 71.2 15 No No
10 empty 1.94 63.8 10.3 No No
2GMX_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 69.8 38.5 Yes Yes
2 bound 1.88 75 20.9 No No
3 empty 1.99 64.2 37.8 No No
4 empty 1.9 63.2 17.8 No No
5 empty 1.96 64.6 21.7 No No
6 empty 1.26 82.5 14.7 No No
7 empty 2.3 67.5 13.1 No No
8 empty 1.98 70.8 9.8 No No
9 empty 2.26 68.9 15.4 No No
10 empty 2.18 75.2 12.3 No No
2G01_B Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.05 66.8 47 Yes Yes
2 empty 1.74 64.6 25.5 No No
3 empty 2.16 67.1 15.2 No No
4 empty 1.77 61.9 22.8 No No
5 empty 2.32 59.6 19.6 No No
6 empty 2.38 56.3 15.7 No No
7 empty 1.5 56.8 14.6 No No
8 empty 1.98 55.3 16.1 No No
9 empty 2.15 58.9 20.3 No No
10 empty 2.38 67.4 11.3 No No
1UKI_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 66.1 50.3 Yes Yes
2 empty 2.26 64.2 33.9 No No
3 empty 1.93 65.3 19.9 No No
4 empty 1.85 67.7 24.9 No No
5 empty 1.7 68.7 11.9 No No
6 empty 1.99 71.5 10.5 No No
7 empty 2.27 63.8 8.4 No No
8 empty 1.93 76.8 8.6 No No
9 empty 2.31 66.4 10.5 No No
10 empty 2.16 60.3 10.6 No No
5LW1_B Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 80.1 23.6 Yes Yes
2 empty 2.4 54.4 27.7 No No
3 empty 2.13 63.5 23.5 No No
4 empty 1.58 65.9 17 No No
5 bound 1.93 62.6 15.9 No No
6 empty 1.87 58.1 18.1 No No
7 empty 1.96 54.2 16.9 No No
8 empty 2 59.8 18.7 No No
9 empty 2.11 57.4 14.3 No No
10 empty 2.06 65.1 15.3 No No
3O2M_B Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 68 38.9 Yes Yes
2 empty 1.87 69.5 38.2 No No
3 bound 1.53 68.3 18.8 No No
4 empty 1.82 64 19.7 No No
5 empty 2.18 61.7 23.4 No No
6 bound 2.01 76.5 12.7 No No
7 empty 1.98 68.6 15.3 No No
8 empty 2.08 64.2 17.1 No No
9 empty 2.29 75.4 13.8 No No
10 empty 2.03 69.2 17.9 No No
3VUG_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 68.3 38 Yes Yes
2 empty 2.11 69.5 37.4 No No
3 bound 2.27 60.1 33.7 No No
4 empty 1.89 69.5 17.2 No No
5 empty 2.23 67.1 12.7 No No
6 empty 1.97 62.4 19.6 No No
7 empty 1.81 71.8 18.6 No No
8 empty 2.49 70.6 10.8 No No
9 empty 2.34 75.7 10.8 No No
10 empty 2.37 63 13.7 No No
3O17_B Mitogen-activated protein kinase 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 61.3 29.3 Yes No
2 empty 2.04 65.8 23.3 No No
3 bound 2.12 71.6 18.9 No No
4 bound 2.09 66.3 27.3 No No
5 empty 2.22 68 16.3 No No
6 empty 1.67 70.1 15.8 No No
7 empty 2.06 63.4 17.8 No No
8 empty 1.48 61.9 12.7 No No
9 empty 1.63 63.7 13.9 No No
10 empty 2.27 61.9 15.1 No No
4UX9_B Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 71.9 26.9 Yes Yes
2 empty 1.85 62 25.6 No No
3 empty 2.38 59.2 24.3 No No
4 bound 2.08 73.6 13.5 No No
5 empty 1.37 63.1 15.6 No No
6 empty 1.84 67.4 15 No No
7 empty 2.05 51.3 14.8 No No
8 empty 2.31 60.2 21.1 No No
9 empty 1.62 63.1 14.9 No No
10 empty 2.27 56.3 14.9 No No
4L7F_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.05 69.6 49 Yes Yes
2 empty 2.22 63.1 42 No No
3 empty 2.28 65.9 32.9 No No
4 empty 2.03 66.2 44.4 No No
5 empty 2.15 69.6 20.7 No No
6 empty 2.38 71.1 26.5 No No
7 empty 1.61 72.6 14.2 No No
8 empty 1.87 74.6 9.4 No No
9 empty 2.06 73.5 11.5 No No
10 empty 1.23 72.3 7.5 No No
2NO3_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 69.4 39.5 Yes Yes
2 empty 2.26 56.5 22.5 No No
3 empty 1.58 65.7 17 No No
4 empty 1.81 56.2 18.6 No No
5 bound 2.36 91 0 Yes No
6 empty 2.27 65.8 13.2 No No
7 empty 2.41 60.7 15.2 No No
8 empty 1.81 65.3 13.3 No No
9 empty 2.3 57.9 10.5 No No
10 empty 1.63 68 11.8 No No
3VUM_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 68.3 48.2 Yes Yes
2 bound 1.81 68.4 24.6 No No
3 empty 2.08 67 17.5 No No
4 empty 2.3 69.9 15.2 No No
5 empty 2.04 67 14.9 No No
6 empty 2.45 61.8 14.7 No No
7 empty 2.19 68.6 11.7 No No
8 empty 1.97 78.4 9.1 No No
9 empty 2.19 61.9 10.9 No No
10 empty 2.23 62.6 10.7 No No
4YR8_C Mitogen-activated protein kinase 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 65.4 44.5 Yes No
2 empty 2.48 63.8 40.3 No No
3 empty 1.76 67 18.4 No No
4 empty 2.4 63.3 23 No No
5 empty 2.11 65.9 18.4 No No
6 empty 2.13 68.4 18.2 No No
7 empty 1.71 68.1 12.4 No No
8 empty 1.91 64.1 14.6 No No
9 empty 2.2 69.3 12.8 No No
10 empty 2.13 69.1 12.1 No No
2XS0_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 73 41.3 Yes Yes
2 empty 2.28 66.1 30.5 No No
3 empty 2.28 60.5 29.5 No No
4 empty 2.38 62 17.6 No No
5 empty 2.17 68.2 18.2 No No
6 empty 2.27 64.5 19.4 No No
7 empty 2.36 66.8 20.4 No No
8 empty 2.14 68.6 23.3 No No
9 empty 1.75 67.9 14.1 No No
10 empty 2.13 65.6 14.2 No No
3VUI_A Mitogen-activated protein kinase 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 54.6 32 Yes No
2 empty 1.92 73.6 19.9 No No
3 empty 2.03 68 18.5 No No
4 empty 1.74 67.3 13.6 No No
5 empty 2.35 57.3 15.3 No No
6 empty 1.86 72.6 13.8 No No
7 empty 2.16 62.2 15.1 No No
8 empty 2.31 67.6 13.3 No No
9 empty 1.77 65.1 10.6 No No
10 bound 2.25 60.3 10.7 No No
3VUK_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 72.2 19.5 Yes Yes
2 empty 1.91 65.1 17.4 No No
3 empty 2.07 65 23.5 No No
4 bound 2.2 74.3 17.7 No No
5 empty 2.34 52.7 25.7 No No
6 empty 2.2 59 18 No No
7 empty 1.97 70.3 13.2 No No
8 empty 2.32 60.7 15.5 No No
9 empty 2.24 70.6 13.5 No No
10 empty 1.81 73.1 10.2 No No
3ELJ_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 68.7 50 Yes Yes
2 empty 1.8 68.1 20 No No
3 empty 2.53 65.9 25.9 No No
4 empty 2.26 65.4 24 No No
5 empty 1.55 67.9 16.9 No No
6 empty 2.33 73.4 12.5 No No
7 empty 2.29 64.4 14.1 No No
8 empty 2.01 69.1 7.8 No No
9 empty 1.55 62.9 11.6 No No
10 empty 2.58 58.8 11.6 No No
4G1W_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 68.7 44.4 Yes Yes
2 empty 2.15 68.7 28.9 No No
3 empty 2.54 63.2 32.6 No No
4 empty 2.14 70.5 15.9 No No
5 empty 1.64 71.3 12.9 No No
6 empty 2.29 66.5 14.8 No No
7 empty 2.24 62.6 13.5 No No
8 empty 1.98 65.3 12.1 No No
9 empty 2.02 73.6 11 No No
10 empty 2.07 63.3 16.7 No No
2G01_A Mitogen-activated protein kinase 8 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 71.2 35.1 Yes No
2 empty 2.45 63.9 22.7 No No
3 bound 1.84 67.6 16.5 No No
4 empty 1.44 69.9 18.3 No No
5 empty 1.73 57.8 16.7 No No
6 empty 2.23 63.3 17.5 No No
7 empty 2.13 58.4 14.6 No No
8 empty 2.19 69.2 14.1 No No
9 empty 1.72 69.1 14.1 No No
10 empty 1.84 63.9 15.8 No No
1UKH_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 66.5 38.6 Yes Yes
2 empty 1.91 61.9 34.3 No No
3 empty 2.1 66 24.9 No No
4 empty 2.25 67.1 17.8 No No
5 empty 2.19 66.8 22.1 No No
6 empty 2.04 66.6 12.8 No No
7 empty 2.19 65.5 16.4 No No
8 empty 1.83 75.8 11.3 No No
9 empty 2.23 59.6 15.7 No No
10 empty 1.99 74.9 11.6 No No
2GMX_B Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 70.9 25.2 Yes Yes
2 empty 2.27 58.9 27.6 No No
3 bound 2.11 67.1 16.9 No No
4 empty 1.54 67.2 15.8 No No
5 empty 2.1 54.9 22.8 No No
6 empty 2.27 60 18.7 No No
7 empty 2.33 53.5 19.4 No No
8 empty 1.89 61.9 14.7 No No
9 empty 2.21 68.6 12.3 No No
10 empty 1.72 70 11.4 No No
2XRW_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.26 66.3 41.7 Yes Yes
2 empty 2.26 58.3 26.2 No No
3 empty 2.33 61.6 21.3 No No
4 empty 2.12 68.8 13.8 No No
5 empty 1.65 63.1 11.3 No No
6 empty 2.21 61.2 16.9 No No
7 empty 1.76 61.7 12.5 No No
8 empty 2.13 73 12.8 No No
9 empty 1.94 66.4 12.1 No No
10 empty 1.97 67.1 13 No No
4YR8_F Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 67 32.7 Yes Yes
2 empty 2.2 62.3 29.4 No No
3 empty 1.67 67.1 22 No No
4 empty 2.18 61.6 19.3 No No
5 empty 2.58 69.5 24.3 No No
6 empty 1.62 66.9 12.4 No No
7 empty 2.03 76.1 10.6 No No
8 empty 2.38 70.6 11.9 No No
9 empty 2.32 71 14.8 No No
10 empty 2.02 73.2 11.8 No No
3PZE_A Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 67.6 39.6 Yes Yes
2 empty 1.86 59.8 21 No No
3 bound 1.69 62.2 23.8 No No
4 empty 1.85 63.1 16 No No
5 empty 2.13 50 15.4 No No
6 empty 2.16 58.9 17.1 No No
7 empty 2.32 63.2 13.9 No No
8 empty 2.1 57.2 15 No No
9 empty 1.92 70.6 12.2 No No
10 empty 1.78 56.2 15 No No
4UX9_C Mitogen-activated protein kinase 8 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 74.8 32.6 Yes Yes
2 empty 2.4 56.4 28.9 No No
3 empty 1.99 68.8 20.3 No No
4 empty 1.84 62 21.4 No No
5 empty 1.6 64.7 18.9 No No
6 empty 1.51 58 16.1 No No
7 empty 2.05 61.2 21.2 No No
8 empty 2.29 51.1 14.9 No No
9 empty 1.59 66.3 11.1 No No
10 empty 2.4 74.8 11.9 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed11
Domains assessed as druggable using the strict criteria9
Domains assessed as druggable using the relaxed criteria11

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1UKH_A (107913) Mitogen-activated protein kinase 8 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.35Å Yes Yes
1UKI_A (107914) Mitogen-activated protein kinase 8 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.7Å Yes No
2G01_A (3090619) Mitogen-activated protein kinase 8 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 3.5Å Yes No
2GMX_A (3100214) Mitogen-activated protein kinase 8 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 3.5Å Yes Yes
2H96_A (3100863) Mitogen-activated protein kinase 8 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 3Å Yes Yes
2NO3_A (3150514) Mitogen-activated protein kinase 8 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 3.2Å Yes Yes
2XRW_A (3581000) Mitogen-activated protein kinase 8 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.33Å Yes Yes
2XS0_A (3590012) Mitogen-activated protein kinase 8 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.6Å Yes Yes
3ELJ_A (3380835) Mitogen-activated protein kinase 8 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 1.8Å Yes Yes
3O17_A (3640586) Mitogen-activated protein kinase 8 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 3Å Yes Yes
3O2M_A (3640619) Mitogen-activated protein kinase 8 Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.7Å Yes Yes
Ligand-based Druggability Score: 1.7
Ligand-based Druggability Score Percentile: 96%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


MAPK8 is involved in 163 interactions in the network.


Druggability
Overall Druggability Percentile: 94.31
Druggability for Cancer Therapeutics: 97.86
Druggability for Other Therapeutics: 46.50
Cancer-Associated
Cancer-associated percentile : 94.72
Network Articulation Point
Is MAPK8 critical for communication in the network?


Detailed Graph Legend:Help