Molecular Target Synopsis
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MMP13 (P45452) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed110
Chains with at least one site assessed as druggable using the strict criteria71
Chains with at least one site assessed as druggable using the relaxed criteria110


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3WV1_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 68.5 42.7 Yes Yes
2 empty 2.18 60 43.1 No No
3 empty 2.36 62.6 25.4 No No
4 empty 2.03 66.4 18.4 No No
5 empty 2.41 59.8 11.7 No No
6 empty 2.48 70 9.6 No No
7 empty 2.02 65.3 7.3 No No
8 empty 2.57 65.4 7 No No
9 empty 1.94 63.9 6.7 No No
10 empty 1.68 74.7 5.7 No No
2OZR_F Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 67.8 45.7 Yes Yes
2 empty 2.11 70.1 29.2 No No
3 empty 2.49 58.8 24.2 No No
4 empty 2.09 64.6 16.8 No No
5 empty 2.67 66 9.3 No No
6 empty 2.4 64 8.6 No No
7 empty 2.05 60.5 9.3 No No
8 empty 2.21 56.1 12.7 No No
9 empty 1.94 63.5 9.2 No No
10 empty 1.98 53.5 7.4 No No
4G0D_C Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 62.7 41.3 Yes No
2 bound 2.17 67.6 34.7 No No
3 bound 2.2 70.2 19.8 No No
4 empty 2.06 69.2 19.3 No No
5 bound 1.88 71.8 14.8 No No
6 empty 2 73.9 14.1 No No
7 empty 2.26 66.7 15 No No
8 empty 2.2 61.4 18.9 No No
9 bound 1.93 69.5 14.9 No No
10 empty 2.1 54.8 16.7 No No
3WV3_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 67.3 44.6 Yes Yes
2 empty 1.94 63.8 14.3 No No
3 empty 2.18 73 13 No No
4 empty 2.23 67.3 10.8 No No
5 empty 2.33 62.3 18.1 No No
6 empty 2.3 64.9 11.3 No No
7 empty 2.41 61.7 10.9 No No
8 empty 2.64 65.4 10 No No
9 empty 1.8 53.8 10.1 No No
10 empty 2.2 62 6.9 No No
2OW9_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 69.4 41.8 Yes Yes
2 empty 2.06 62.3 38.3 No No
3 bound 2.31 65.9 14.5 No No
4 empty 2.26 64.9 14.7 No No
5 empty 2.7 57.1 13.1 No No
6 empty 2.51 69.5 8.5 No No
7 empty 2.39 60.6 9.2 No No
8 empty 2.28 40.6 9.4 No No
9 empty 2.07 61.7 10.6 No No
10 empty 2.31 46.7 10.1 No No
4L19_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 60.6 37.2 Yes No
2 bound 1.83 69.2 19.9 No No
3 bound 2.19 67.7 16.1 No No
4 empty 2.21 63.9 17.4 No No
5 empty 2.31 59.9 15.6 No No
6 empty 1.95 65.9 12.7 No No
7 empty 2.27 63.8 11.4 No No
8 empty 2.27 65.7 14.3 No No
9 empty 2.71 60.7 9.5 No No
10 empty 2.39 55.9 9.8 No No
1YOU_B Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 71.7 31.6 Yes No
2 empty 2.13 61.8 40.7 No No
3 empty 2.46 65.2 18.1 No No
4 empty 2.36 66.8 14.7 No No
5 empty 2.14 70.3 12.1 No No
6 empty 2.24 54.9 15.3 No No
7 empty 2.06 66.1 13.7 No No
8 empty 1.75 65.2 10.4 No No
9 empty 2.6 64.7 8.9 No No
10 empty 2.02 46.6 12.3 No No
5BPA_B Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 65.6 46.9 Yes No
2 empty 1.95 61.5 18.2 No No
3 empty 2 70.4 15.9 No No
4 empty 2.11 67.6 14.8 No No
5 empty 2.17 62.7 14.6 No No
6 empty 2.53 55.6 10.7 No No
7 empty 2.66 65 9.4 No No
8 empty 2.22 60.8 10.4 No No
9 empty 2.31 59 8.9 No No
10 empty 1.69 45.6 7.9 No No
1EUB_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 61.5 41.8 Yes No
2 empty 2.49 65.6 30.8 No No
3 empty 2.18 59.6 20.7 No No
4 empty 2.12 75.8 15.9 No No
5 empty 1.58 71.1 8.8 No No
6 empty 1.99 67.5 12.4 No No
7 empty 2.85 66.3 11 No No
8 empty 2.15 65.5 8.3 No No
9 empty 2.62 62.8 13 No No
10 empty 2.24 71 7 No No
1XUD_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 67.4 47.2 Yes Yes
2 empty 2.25 63.6 18.2 No No
3 empty 2.01 64.7 14.5 No No
4 empty 1.98 73.5 10.9 No No
5 empty 2.11 64.8 14.2 No No
6 empty 2.55 65.6 10.6 No No
7 empty 2.13 58.1 10.4 No No
8 empty 2.49 50 7.6 No No
9 empty 1.75 45.8 6.9 No No
10 empty 1.94 57.5 8.2 No No
2YIG_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 70 38.5 Yes Yes
2 empty 2.42 63.9 35.3 No No
3 empty 1.98 60 26.8 No No
4 empty 2.12 81.1 9.6 No No
5 empty 2.35 58.6 11.7 No No
6 empty 2.68 63.8 8.5 No No
7 empty 2.06 70.4 8.5 No No
8 empty 2.29 44.6 9 No No
9 empty 2.08 58.1 10.7 No No
10 empty 2.4 65.8 5.8 No No
3O2X_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 66.9 45.4 Yes Yes
2 empty 2.23 69.5 29.3 No No
3 empty 2.36 66 22 No No
4 bound 2.57 64.9 18.5 No No
5 empty 2.56 67.1 12 No No
6 empty 1.95 66.8 11 No No
7 empty 2.18 56.1 9.3 No No
8 empty 1.98 59.6 8.1 No No
9 empty 2.19 40.6 8.7 No No
10 empty 1.91 63.4 7.4 No No
3I7G_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 70.7 33.1 Yes No
2 empty 2.01 60.6 27.2 No No
3 empty 2.43 59.2 24 No No
4 empty 1.98 64.2 21.1 No No
5 empty 2.39 71.6 17.3 No No
6 empty 2.23 70.8 11.1 No No
7 empty 2.5 66.5 10 No No
8 empty 2.56 67.5 11.8 No No
9 empty 2.7 52.8 10.7 No No
10 empty 2.33 68.6 8.9 No No
1XUR_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 66 43.3 Yes No
2 empty 1.96 59.7 27.5 No No
3 empty 2.38 65.5 13.7 No No
4 empty 2.5 69.6 10.1 No No
5 empty 2.18 58.6 8.9 No No
6 empty 2.32 64.1 7.1 No No
7 empty 2.03 58.6 6.6 No No
8 empty 2.15 58.1 7.9 No No
9 empty 2.08 63.2 6.3 No No
10 empty 2.46 67.9 5.7 No No
4L19_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.29 69.9 28.6 Yes Yes
2 bound 1.8 65.4 31.4 No No
3 empty 2.17 59.4 24.1 No No
4 empty 2.02 56.7 23.1 No No
5 empty 2 67.2 18.1 No No
6 empty 2.37 64.4 15.3 No No
7 empty 2.41 63.1 12.1 No No
8 empty 2.24 59.5 10.9 No No
9 empty 2.33 52.7 11.4 No No
10 empty 1.98 49.4 11.2 No No
5UWK_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 68.1 43.2 Yes Yes
2 empty 2.37 65.6 15.8 No No
3 empty 2.06 69.1 15.1 No No
4 empty 2 69.7 16.9 No No
5 empty 2.63 68.2 10.6 No No
6 empty 2.33 62.5 11.5 No No
7 empty 1.96 60.4 13.2 No No
8 empty 1.84 57.7 10.5 No No
9 empty 2.23 60.1 10.6 No No
10 empty 2.12 47.6 6.1 No No
3KEK_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 67.8 39.9 Yes Yes
2 empty 2.23 67.4 24.2 No No
3 empty 2.59 69.2 9.7 No No
4 empty 2.19 60.5 9.8 No No
5 empty 2.18 57.4 12.6 No No
6 empty 2.23 63.9 6 No No
7 empty 2 68.8 6.3 No No
8 empty 1.8 57.9 7.8 No No
9 empty 2.39 71.2 0 No No
10 empty 3.22 69.7 5.8 No No
5UWN_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 69.8 42.4 Yes Yes
2 empty 2.18 66.9 35.9 No No
3 empty 2.04 64.9 24.7 No No
4 bound 2.24 63.4 15.2 No No
5 empty 2.57 69.2 10 No No
6 empty 2.44 61.2 10.3 No No
7 empty 2.17 63.3 9.6 No No
8 empty 2.75 60.7 10.8 No No
9 empty 1.97 63.5 6.1 No No
10 empty 2.71 63.5 5.1 No No
4FVL_B Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 61 44.5 Yes No
2 bound 2.27 66.6 32.7 No No
3 empty 2 72.6 16.7 No No
4 bound 2.01 69.4 11.1 No No
5 bound 1.94 66.6 14.1 No No
6 empty 1.86 69.6 9.5 No No
7 bound 2.11 59.8 13.9 No No
8 bound 2.33 57.2 13.6 No No
9 bound 2.19 64.1 10.6 No No
10 bound 1.72 94.3 0 Yes No
3KEK_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 67.9 43.6 Yes Yes
2 empty 2.12 62.1 31.7 No No
3 empty 2.18 68.1 13.5 No No
4 empty 2.55 67.1 9.4 No No
5 empty 2.18 59 11.7 No No
6 empty 2.11 57.7 11.5 No No
7 empty 2.05 53.6 9.5 No No
8 empty 2.51 65.7 6.3 No No
9 empty 2.36 64.8 7.6 No No
10 empty 2.3 61.7 6.2 No No
2OZR_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 68.2 40.9 Yes Yes
2 empty 2.03 62.8 37.6 No No
3 empty 2.24 67.4 17.3 No No
4 empty 2.47 54.8 10.7 No No
5 empty 2.55 70 9 No No
6 empty 2.38 58.8 11.9 No No
7 empty 2.45 48.8 12.2 No No
8 empty 2.13 59.2 12.9 No No
9 empty 2.08 57.9 9.5 No No
10 empty 2.22 54.4 10.6 No No
830C_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 68.4 46.7 Yes Yes
2 empty 1.77 72.3 13.5 No No
3 empty 2.27 62.6 15.8 No No
4 empty 2.12 65.6 13.4 No No
5 empty 2.5 56 11.4 No No
6 empty 2.61 62.1 9.3 No No
7 empty 2.16 59.1 9 No No
8 empty 2.23 57.1 10.5 No No
9 empty 2.02 54.5 9.9 No No
10 empty 1.8 52.2 6.9 No No
5UWM_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 69.7 35.6 Yes Yes
2 empty 2.27 68.8 23.8 No No
3 empty 2.27 64.3 17.1 No No
4 empty 2.11 64.3 17.1 No No
5 empty 2.56 62.6 19.3 No No
6 empty 2.57 67.7 10.7 No No
7 empty 2 55.9 9.9 No No
8 empty 2.2 53.3 10.2 No No
9 empty 1.88 62 9.6 No No
10 empty 2.43 73.5 6.6 No No
3LJZ_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 69.3 40 Yes Yes
2 empty 2.1 62.9 32.6 No No
3 empty 2.32 64.2 23.2 No No
4 empty 2 63.4 15.3 No No
5 bound 2.48 66.7 15.3 No No
6 empty 2.58 68.8 9.6 No No
7 empty 2.14 54.7 11.8 No No
8 empty 2.25 57 13.7 No No
9 empty 2.02 55.6 9.2 No No
10 empty 2.68 63.1 7.8 No No
3KEJ_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 68.5 42.5 Yes Yes
2 empty 2.17 61.9 33.8 No No
3 empty 2.38 66.1 13.6 No No
4 empty 2.22 58 14.9 No No
5 empty 2.53 67.8 9.2 No No
6 empty 2.09 51 11 No No
7 empty 1.93 63.1 6.5 No No
8 empty 2.07 54.3 9.8 No No
9 empty 2.27 59.4 10.7 No No
10 empty 1.99 64.8 6.6 No No
5B5P_B Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 65.5 44.9 Yes No
2 empty 2.14 67 32.4 No No
3 empty 2.07 63 17.6 No No
4 empty 2.29 64.4 17.8 No No
5 empty 2.24 59.3 11.8 No No
6 empty 2.07 61.4 10.7 No No
7 empty 2.58 64.1 11.5 No No
8 empty 2 55.2 9.9 No No
9 empty 1.95 73.3 6.3 No No
10 empty 1.63 54.5 5.7 No No
3I7I_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 70 35.8 Yes Yes
2 empty 2.39 63.9 34.9 No No
3 empty 2.22 62.6 34.1 No No
4 empty 2.1 69.9 12.6 No No
5 empty 2.57 65 9.7 No No
6 empty 2.12 68.8 8 No No
7 empty 1.96 51.6 10.5 No No
8 empty 2.29 50.9 10.9 No No
9 empty 2.09 61.8 6.6 No No
10 empty 2.38 55.6 6.5 No No
5B5O_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 68.7 45.1 Yes Yes
2 empty 2.11 75.4 14.7 No No
3 empty 2.05 67.5 14.7 No No
4 empty 1.8 72.7 14.9 No No
5 empty 2.09 61.6 19.9 No No
6 empty 2.4 66.2 16.2 No No
7 empty 2.3 56.6 12.6 No No
8 empty 1.71 67.2 10.4 No No
9 empty 2.68 67.5 9.5 No No
10 empty 2.21 61.7 8.4 No No
3LJZ_D Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 67.5 42.5 Yes Yes
2 bound 2.03 69.1 17.4 No No
3 bound 2.51 65.1 19.8 No No
4 empty 2.03 68.3 18.8 No No
5 empty 2.49 69.1 12.4 No No
6 empty 2 56.4 12.9 No No
7 empty 2.2 59.6 13.6 No No
8 empty 2.93 56.9 9.4 No No
9 empty 2.25 56.7 7.1 No No
10 empty 2.11 51 7.3 No No
2OW9_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 66.7 46.9 Yes Yes
2 empty 1.97 72.8 12.4 No No
3 empty 2.26 60.3 18.8 No No
4 empty 2.45 64.2 11.3 No No
5 empty 2.27 62.6 11.9 No No
6 empty 2.69 65.4 9.3 No No
7 empty 2.53 41.3 14.1 No No
8 empty 2.11 60.6 7.7 No No
9 empty 1.95 59.9 11 No No
10 empty 2.24 61.4 9.4 No No
4FU4_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 62 39 Yes No
2 bound 2.22 67.8 34.5 No No
3 empty 1.64 67 25.9 No No
4 bound 2.08 63.2 27.8 No No
5 empty 1.81 67.2 15.7 No No
6 empty 2.03 74.9 13.7 No No
7 empty 2.01 72.7 14.3 No No
8 empty 2.35 62.3 14.9 No No
9 empty 2.22 60.7 15.6 No No
10 bound 1.96 64.3 15 No No
1XUC_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 67.6 47.4 Yes Yes
2 empty 2.25 63 16.5 No No
3 empty 2.04 64.5 14.1 No No
4 empty 1.95 71 10.8 No No
5 empty 2.12 65.9 12.5 No No
6 empty 2.56 67 10.5 No No
7 empty 2.53 66.1 7.6 No No
8 empty 2.57 54.1 7.2 No No
9 empty 1.76 47.2 7.3 No No
10 empty 2.62 58 7.8 No No
4G0D_B Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 59.8 41.2 Yes No
2 empty 2.33 64.7 33.3 No No
3 empty 1.68 65.2 26.2 No No
4 empty 1.93 67.8 18.1 No No
5 empty 1.97 68 17.1 No No
6 empty 2.23 65 14.8 No No
7 bound 2.1 70.9 13.6 No No
8 empty 1.95 61 14.4 No No
9 empty 1.95 51.7 15.2 No No
10 empty 2.09 58.4 11.4 No No
3I7G_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 67.3 45.3 Yes Yes
2 empty 2.29 70 27.9 No No
3 empty 2.18 66.8 14 No No
4 empty 2.61 64 10.3 No No
5 empty 2.39 58.6 10.6 No No
6 empty 2.16 58.6 7.7 No No
7 empty 2.41 69.7 8 No No
8 empty 1.99 57.1 9.3 No No
9 empty 1.99 40.4 7.5 No No
10 empty 2.27 60.1 5.7 No No
1FLS_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 73.4 28.1 Yes No
2 empty 1.8 63.7 20.7 No No
3 empty 2.04 67.5 19.3 No No
4 empty 2.2 60.4 15.7 No No
5 empty 2.22 70.3 11.6 No No
6 empty 1.68 61.3 11.7 No No
7 empty 2.51 65.8 10.9 No No
8 empty 1.99 64.5 12.1 No No
9 empty 2.32 54.9 12.8 No No
10 empty 1.84 73.3 9.2 No No
3KRY_D Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 65.3 46.9 Yes No
2 empty 2.2 67.2 32.8 No No
3 empty 2.18 67.1 17.3 No No
4 empty 2.47 67.5 13.7 No No
5 empty 2.41 60.1 11.2 No No
6 empty 2.65 63.1 8.7 No No
7 empty 2.25 62.7 10.3 No No
8 empty 2.04 62.7 6.1 No No
9 empty 2.04 54 9.3 No No
10 empty 2.72 60.2 6.5 No No
2PJT_D Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 71.3 38.2 Yes No
2 empty 2.08 67.8 14.3 No No
3 empty 1.84 73.8 13.2 No No
4 empty 2.37 71.1 16.7 No No
5 empty 2.04 65.7 17.6 No No
6 empty 2.37 62.9 14.8 No No
7 empty 2.56 69.7 10.9 No No
8 empty 2.43 64.2 11.8 No No
9 empty 2.16 69.6 9.9 No No
10 empty 2.24 57.3 10 No No
5UWN_E Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 74.4 31.8 Yes Yes
2 empty 2.11 67.8 29.8 No No
3 bound 2.02 64.4 18.7 No No
4 empty 2.17 60.6 16.9 No No
5 empty 2.22 74.9 11.3 No No
6 empty 2.26 62 12.6 No No
7 empty 1.86 57.3 12.6 No No
8 empty 2.6 66.1 10.3 No No
9 empty 2.03 72 8.8 No No
10 bound 2.27 58 10.2 No No
2OZR_D Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 71.5 37.9 Yes Yes
2 empty 2.15 61.2 38.4 No No
3 empty 2.64 60.4 25.5 No No
4 empty 2.09 55.9 11.2 No No
5 empty 2.61 64 10.8 No No
6 empty 2.22 61.2 9.2 No No
7 empty 2.37 65.1 8.1 No No
8 empty 2.3 59.1 12.2 No No
9 empty 2.21 54.5 12.8 No No
10 empty 3.35 57 6.2 No No
1XUR_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 67.8 46.6 Yes Yes
2 empty 2.24 64.1 18.2 No No
3 empty 1.99 65.3 15.6 No No
4 empty 2.26 71.4 11.9 No No
5 empty 2.2 65.8 13.6 No No
6 empty 2.03 67.9 11.2 No No
7 empty 2.59 68.2 10.6 No No
8 empty 2.04 58.5 7.7 No No
9 empty 2.47 57.4 7.2 No No
10 empty 1.75 50.4 6.9 No No
3WV3_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 68.4 41.7 Yes Yes
2 empty 1.97 61.3 32.2 No No
3 empty 2.18 61.5 24.9 No No
4 empty 2.58 68.3 8.3 No No
5 empty 2.39 49.2 9 No No
6 empty 1.78 68.1 8.7 No No
7 empty 2.29 61.3 8.9 No No
8 empty 2.1 57.6 8.1 No No
9 empty 2.66 58.7 7 No No
10 empty 2.05 63.9 5.7 No No
2YIG_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 67.4 45.5 Yes Yes
2 empty 2.06 63.9 19.1 No No
3 empty 1.94 73.4 11.8 No No
4 empty 2.34 63.1 16.6 No No
5 empty 2.29 63.4 16.6 No No
6 empty 2.59 61.6 11.8 No No
7 empty 2.41 60.9 8.5 No No
8 empty 2.13 64.1 10.3 No No
9 empty 2.21 60.6 9.1 No No
10 empty 2.22 58.8 11 No No
1ZTQ_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 70.2 36 Yes Yes
2 empty 2.07 72.9 15.7 No No
3 empty 2.41 61.8 14.5 No No
4 empty 2.38 66.6 14.3 No No
5 empty 2.37 58.6 12.3 No No
6 empty 2.7 66.4 8.7 No No
7 empty 2.04 55 11.7 No No
8 empty 2.32 61.7 12.2 No No
9 empty 1.97 59.3 5.6 No No
10 empty 2.01 57.5 5.8 No No
3ZXH_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 67 44.9 Yes Yes
2 empty 2.39 63.7 17.5 No No
3 empty 2.13 69.8 11.2 No No
4 empty 2.69 66.7 9.5 No No
5 bound 2.1 58.2 8.9 No No
6 empty 2.26 59.6 9.8 No No
7 empty 2.01 60.6 9.7 No No
8 empty 1.71 53.2 6 No No
9 empty 2.27 71 6.7 No No
10 empty 1.9 65.7 6.4 No No
4A7B_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 67.4 43.9 Yes No
2 empty 2.21 62.5 36.9 No No
3 empty 2.39 60.7 26 No No
4 bound 2.07 68.6 15 No No
5 empty 2.28 68.7 12.7 No No
6 empty 2.6 64.6 10 No No
7 empty 2.22 42.8 8.4 No No
8 empty 2.44 63.8 6.6 No No
9 empty 2.21 65.5 6.4 No No
10 empty 2.7 60 6.4 No No
4JPA_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 69 38.8 Yes Yes
2 empty 2.34 62.8 35.1 No No
3 empty 1.87 55.9 32.7 No No
4 empty 2.02 64.1 13.9 No No
5 empty 2.55 64.5 10.9 No No
6 empty 2.33 64.4 10.8 No No
7 empty 2.04 61 11.2 No No
8 empty 2.32 63.9 9.6 No No
9 empty 1.17 58.3 6.2 No No
10 empty 2.2 66.4 8.9 No No
2OZR_C Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 70 40.8 Yes Yes
2 empty 2.1 66.5 24.3 No No
3 empty 2.67 60.8 29.7 No No
4 empty 2.57 64.6 10 No No
5 empty 2.35 57.5 14.9 No No
6 empty 2.29 42.7 8.7 No No
7 empty 2.31 65.3 7.7 No No
8 empty 2.88 56.6 9.8 No No
9 empty 2.08 62.4 8.9 No No
10 empty 2.93 59.1 10.5 No No
2OZR_G Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 68.4 44.7 Yes Yes
2 empty 1.93 67.5 27.3 No No
3 empty 2.15 70.1 11.3 No No
4 empty 2.19 66.8 10.5 No No
5 empty 2.61 64.2 9.1 No No
6 empty 2.35 63 10.6 No No
7 empty 2.22 59.3 8.6 No No
8 empty 2.14 51.9 12.5 No No
9 empty 2.21 62.7 7.8 No No
10 empty 2.34 72.1 8 No No
3LJZ_C Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 66.7 43.3 Yes Yes
2 bound 2.22 65.9 30.8 No No
3 empty 2.28 67.8 31.9 No No
4 empty 2.25 59 10.7 No No
5 empty 2.57 63.4 11.8 No No
6 empty 2.17 56 11.9 No No
7 empty 2.39 66.4 5.7 No No
8 empty 1.92 61.7 8.4 No No
9 empty 2.75 48.8 9.5 No No
10 empty 2.28 71.6 5.7 No No
4G0D_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 61 37.8 Yes No
2 bound 2.24 64.5 33.7 No No
3 bound 2.3 69.3 26.2 No No
4 empty 1.71 65.9 28.7 No No
5 bound 2.16 70.9 18.9 No No
6 empty 2.11 73.4 16.7 No No
7 empty 2.41 60.5 21.2 No No
8 bound 2.14 75.8 14.8 No No
9 empty 2.29 67.6 11.2 No No
10 empty 1.93 67.2 15.4 No No
5BOY_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 66.1 40.6 Yes Yes
2 empty 2.33 60.6 24.1 No No
3 empty 1.96 60.8 26.7 No No
4 empty 2.23 66.6 16.6 No No
5 empty 2.16 71.7 16.4 No No
6 empty 2.55 66.3 9 No No
7 empty 2.29 59.7 8.6 No No
8 empty 2.02 58.3 10 No No
9 empty 3.04 71.7 7.1 No No
10 empty 2.33 64.2 6.4 No No
3KEC_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.34 70.7 28.1 Yes Yes
2 bound 1.8 61.7 21.9 No No
3 empty 1.92 61.3 19.5 No No
4 bound 1.81 73.2 15.7 No No
5 empty 1.93 62.7 19.8 No No
6 empty 1.96 62.8 15.6 No No
7 empty 2.35 52.7 13.6 No No
8 bound 2.3 63.4 13.3 No No
9 empty 2.23 62 12.2 No No
10 empty 2.36 63 11.1 No No
3ZXH_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 64.7 43.5 Yes No
2 empty 2.42 59.8 24.3 No No
3 empty 2.28 72.8 13.9 No No
4 empty 2.4 65.6 16.3 No No
5 empty 2.66 64.1 9.9 No No
6 empty 2.48 62.3 11.8 No No
7 empty 1.96 56.2 9 No No
8 empty 2.03 59.3 9 No No
9 empty 2.4 61.3 7.5 No No
10 empty 2.5 42.7 7.8 No No
5BPA_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 67.6 38.5 Yes Yes
2 empty 1.94 60.1 27.2 No No
3 empty 2.12 63.7 20.5 No No
4 empty 2.59 62.9 9.3 No No
5 empty 2.18 61.1 9.5 No No
6 empty 2.4 45.3 8.7 No No
7 empty 2.37 62.2 6.1 No No
8 empty 1.98 63.1 9.9 No No
9 empty 2.99 77.1 6.2 No No
10 empty 2.88 43.8 7.4 No No
3O2X_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 68.3 45.6 Yes Yes
2 empty 2.35 67.7 31.1 No No
3 empty 2.21 68.2 19.6 No No
4 bound 2.32 65.9 18.1 No No
5 empty 2.35 66.1 11.1 No No
6 empty 2.21 58 14.5 No No
7 empty 2.58 65.3 11.4 No No
8 empty 2.22 62 12.5 No No
9 empty 2.68 45.7 7.9 No No
10 empty 2.23 66.7 6.9 No No
456C_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 69.8 31.2 Yes No
2 empty 2.16 63.8 20.2 No No
3 empty 1.83 67.9 12 No No
4 empty 2.06 62.8 18.5 No No
5 empty 1.86 68.4 10.6 No No
6 empty 1.9 71 10.9 No No
7 empty 2.18 66.8 12.2 No No
8 empty 2.6 62.8 8.8 No No
9 empty 2.18 67.6 8.7 No No
10 empty 2.17 61.8 8.9 No No
3KRY_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 68.6 41.2 Yes Yes
2 empty 2.02 64.5 37.7 No No
3 empty 2 62.5 17.5 No No
4 empty 1.94 70.6 14.6 No No
5 empty 2.5 72.8 16.1 No No
6 empty 2.57 63.8 9.7 No No
7 empty 2.21 55.9 12.2 No No
8 empty 2.2 63.9 6.7 No No
9 empty 2.35 57.4 11 No No
10 empty 1.83 64.5 9 No No
3KEJ_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 68.9 40.3 Yes Yes
2 empty 2.32 67.4 22.1 No No
3 empty 2.41 62.7 21.2 No No
4 empty 2.26 59.4 9.4 No No
5 empty 2.54 70.9 8.2 No No
6 empty 2.07 51.6 11 No No
7 empty 1.97 60.4 11.1 No No
8 empty 2.13 58.7 11.4 No No
9 empty 2.18 61.4 10.2 No No
10 empty 2.27 57.5 6 No No
5UWL_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 72.9 34.5 Yes Yes
2 empty 1.96 65.8 30.4 No No
3 empty 2.43 65.9 19.4 No No
4 empty 1.85 61.3 12.5 No No
5 empty 2.33 64.9 19.1 No No
6 empty 2.54 69.8 11.7 No No
7 empty 2.27 60.2 9.9 No No
8 empty 2.4 63.9 10.9 No No
9 empty 2.46 64.1 10.1 No No
10 empty 2.49 70.5 9.6 No No
3KEC_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 67.3 46.3 Yes Yes
2 empty 2.79 57.4 15.8 No No
3 empty 2.2 64.8 12.9 No No
4 empty 2.65 63.7 11.2 No No
5 empty 2.41 46.5 14.6 No No
6 empty 2.01 58.2 10.4 No No
7 empty 2.45 62.6 12.6 No No
8 empty 1.88 60.3 11.4 No No
9 empty 2.54 62.3 6.8 No No
10 empty 1.82 47.5 6.4 No No
2D1N_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 68.6 43.2 Yes Yes
2 empty 2.11 69.2 23.1 No No
3 empty 2.35 72.4 13.4 No No
4 empty 2.58 64.9 9.4 No No
5 empty 2.27 58.3 10 No No
6 empty 1.9 60.9 8.9 No No
7 empty 2.56 70.4 4.7 No No
8 empty 2.68 63.7 5.9 No No
9 empty 2.49 59.5 5.4 No No
10 empty 2.11 65.9 6.4 No No
3ELM_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.05 68.9 47 Yes Yes
2 empty 2.22 64.4 32.4 No No
3 empty 2.54 63 17 No No
4 empty 2.06 67.4 10.5 No No
5 empty 2.67 61.2 10.2 No No
6 empty 2.13 59.3 9.4 No No
7 empty 2.51 60.8 10.9 No No
8 empty 2.26 68 7.5 No No
9 empty 2.06 60 9.1 No No
10 empty 1.59 47.7 6.8 No No
3I7I_B Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 65.7 40.8 Yes No
2 empty 2.49 64.9 18 No No
3 empty 1.79 69.6 15.6 No No
4 empty 2.22 67.2 14.5 No No
5 empty 2 63.1 13.3 No No
6 empty 2.19 65.6 13.7 No No
7 empty 2.76 61.7 10.8 No No
8 empty 2.71 57.2 10.9 No No
9 empty 2.29 61 12.3 No No
10 empty 2.15 60.4 7.7 No No
1PEX_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 69.2 21.7 No No
2 empty 2.35 81.9 15.8 Yes Yes
3 empty 2.09 74.3 12.1 No No
4 empty 2.07 69.7 16.2 No No
5 empty 2.18 69 12.2 No No
6 empty 1.69 57.4 12.5 No No
7 empty 2.68 66.1 13.1 No No
8 empty 2.13 78.7 7.9 No No
9 empty 2.08 66 14.1 No No
10 empty 2.79 76.3 8.6 No No
3TVC_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 71 35.8 Yes No
2 bound 2.15 70.1 24.3 No No
3 empty 2 67 20.9 No No
4 empty 2.5 60.7 27.5 No No
5 bound 1.7 67.9 15.4 No No
6 empty 2.34 62.2 11.7 No No
7 empty 2.09 57.8 15.7 No No
8 empty 2.17 61.7 6.9 No No
9 empty 1.74 73.7 7.8 No No
10 empty 2.11 62.1 9 No No
3KRY_C Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 65.6 41.9 Yes No
2 empty 2.01 72.1 16.3 No No
3 empty 2.13 68.9 18.8 No No
4 empty 2.42 68.4 16.5 No No
5 empty 2.38 58.2 14.2 No No
6 empty 2.69 66.5 9.5 No No
7 empty 2.08 69.2 6.1 No No
8 empty 2.32 57.6 11.3 No No
9 empty 1.99 56.5 9.1 No No
10 empty 2.51 62.8 6.8 No No
5UWN_D Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 67.8 25.5 Yes Yes
2 bound 2 67.9 21 No No
3 empty 2.28 66.3 17.3 No No
4 empty 1.79 46.9 21.5 No No
5 empty 1.98 64.1 13.2 No No
6 empty 1.94 69.5 13.3 No No
7 bound 2.24 60.3 15.2 No No
8 empty 2.27 70.9 12.8 No No
9 empty 2.17 68.3 12.3 No No
10 empty 2.44 62.4 11 No No
1ZTQ_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 68.1 38.9 Yes Yes
2 empty 2.41 64.5 15.7 No No
3 empty 1.98 74.4 10.6 No No
4 empty 2.12 68.3 12.9 No No
5 empty 2.62 65.3 10.2 No No
6 empty 2.44 56.3 12.3 No No
7 empty 1.73 81.2 8.2 No No
8 empty 1.37 81.9 7.7 No No
9 empty 2.56 59.5 7.3 No No
10 empty 2.12 72.6 4.5 No No
5BOT_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 67.3 39.3 Yes Yes
2 empty 2.39 59.3 24.5 No No
3 empty 1.86 60.9 27.3 No No
4 empty 2.36 67 15.7 No No
5 empty 2.21 69.9 13.4 No No
6 empty 2.52 66.1 10 No No
7 empty 2.1 69.4 10 No No
8 empty 2.94 74.6 5.5 No No
9 empty 1.77 65.2 6.3 No No
10 empty 2.09 61.8 5.2 No No
3KRY_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 68 34.4 Yes Yes
2 empty 2.05 65.3 32 No No
3 empty 1.92 62.9 16.1 No No
4 empty 2.01 70.7 13.4 No No
5 empty 2.4 68.8 17.6 No No
6 empty 1.96 55.1 11 No No
7 empty 2.42 44.8 9.7 No No
8 empty 2.6 62.1 11.3 No No
9 empty 2.51 55.3 7.6 No No
10 empty 2.22 62.3 9.9 No No
4FU4_B Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.27 64 35.3 Yes No
2 bound 1.95 63.2 35.1 No No
3 empty 2 58.6 31.5 No No
4 empty 1.64 65.8 26 No No
5 empty 1.8 69.1 15.7 No No
6 empty 2.02 69.8 11.1 No No
7 empty 1.84 71.4 13.1 No No
8 empty 2 58.9 13.1 No No
9 empty 2.1 69.5 10.9 No No
10 bound 2.03 56.7 14.5 No No
5UWM_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 67 42.2 Yes Yes
2 empty 2.11 69.6 24.2 No No
3 empty 2.21 64.5 16.8 No No
4 empty 2.54 72.7 8.3 No No
5 empty 2.12 53 14.3 No No
6 empty 2 61.8 12 No No
7 empty 2.12 54.9 8.5 No No
8 empty 2.56 66.9 5.5 No No
9 empty 2.54 55.8 6.4 No No
10 empty 2.74 63.4 6.3 No No
5BOY_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 66.4 46.9 Yes Yes
2 empty 2.19 69 21.8 No No
3 empty 2.31 63.8 17.1 No No
4 empty 2.61 63.9 11.1 No No
5 empty 2.61 60.9 10.8 No No
6 empty 2.14 56.3 8.6 No No
7 empty 2.27 64.3 10.5 No No
8 empty 1.97 55 9.8 No No
9 empty 1.76 51.4 6.4 No No
10 empty 1.38 71.2 6.9 No No
5B5O_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 65.5 44.3 Yes No
2 empty 2.31 64.4 34.9 No No
3 empty 2.06 75.5 12 No No
4 empty 2.59 68.3 9.1 No No
5 empty 2.53 52.1 10.9 No No
6 empty 2.47 52.7 9.7 No No
7 empty 2.19 71.4 8.5 No No
8 empty 2.34 58.9 9.8 No No
9 empty 1.71 57.6 7.7 No No
10 empty 2.23 60.7 8.1 No No
1XUC_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 66.9 42.9 Yes Yes
2 empty 1.9 60.2 27.4 No No
3 empty 2.35 65.6 15.2 No No
4 empty 2.46 65.1 8.9 No No
5 empty 2.22 70.8 8.3 No No
6 empty 2.51 50.5 11.2 No No
7 empty 2.18 60.7 7.7 No No
8 empty 2.31 78.4 5.5 No No
9 empty 2.63 46.6 7.3 No No
10 empty 2.42 68.8 7.2 No No
4JP4_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.05 66.7 45.9 Yes Yes
2 empty 2.33 71.3 24.1 No No
3 empty 2.12 71.5 11.5 No No
4 empty 2.31 66.7 14 No No
5 empty 2.2 69.7 13.2 No No
6 empty 1.82 66.3 10.1 No No
7 empty 2.63 60.7 11.4 No No
8 empty 2.42 60 11.9 No No
9 empty 2.18 58.4 10 No No
10 empty 1.9 57.6 9.5 No No
1ZTQ_D Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 69.3 34.8 Yes Yes
2 empty 2.49 65.7 29.8 No No
3 empty 1.93 66.3 29.8 No No
4 empty 2.59 63.6 11 No No
5 empty 1.77 56.4 10.6 No No
6 empty 2.06 63.8 8.7 No No
7 empty 2.42 67 9.4 No No
8 empty 2.53 64.2 6.4 No No
9 empty 2.74 64.4 7.7 No No
10 empty 1.4 67.4 5.6 No No
3O2X_C Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 68.3 41 Yes Yes
2 empty 2.07 64.3 34.9 No No
3 empty 1.94 60 18.8 No No
4 empty 2.16 69.7 13.2 No No
5 bound 2.47 72.8 10 No No
6 empty 2.43 67.1 9.2 No No
7 empty 2.09 58.4 9.2 No No
8 empty 1.79 60.3 6 No No
9 empty 2.08 59.1 8.9 No No
10 empty 1.9 61.6 6.2 No No
456C_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 70.7 36.9 Yes Yes
2 empty 2.1 63 21 No No
3 empty 1.91 64.6 16.8 No No
4 empty 2.45 62.4 14.7 No No
5 empty 2.58 66.9 10.8 No No
6 empty 2.31 64.2 9.2 No No
7 empty 2.31 58.6 10.9 No No
8 empty 2.47 76.6 8.4 No No
9 empty 1.13 66.3 8.8 No No
10 empty 2.3 61.9 6.5 No No
3ELM_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 67.8 36.5 Yes Yes
2 empty 2.45 61.1 35.7 No No
3 empty 2.12 60.9 36.4 No No
4 empty 2.41 56.3 11.4 No No
5 empty 2.6 67.2 8.8 No No
6 empty 2.06 69.5 9.4 No No
7 empty 2.28 60.4 8.1 No No
8 empty 1.97 59 9.3 No No
9 empty 2.38 37 7.2 No No
10 empty 2.23 66.3 4.9 No No
4JPA_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 67.4 46.8 Yes Yes
2 empty 2.36 65.4 15.1 No No
3 empty 2.3 56.4 16.1 No No
4 empty 2.65 66.4 9.4 No No
5 empty 2.55 57.7 11.8 No No
6 empty 2.17 56.8 11 No No
7 empty 2.15 61.9 12.8 No No
8 empty 1.63 49.6 7.2 No No
9 empty 2.13 67.9 6.8 No No
10 empty 2.72 75.2 0 No No
3WV2_B Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 62.9 49.4 Yes No
2 empty 1.84 72.7 12.4 No No
3 empty 2.02 66.8 14.2 No No
4 empty 2.4 67.3 13.9 No No
5 empty 2.3 73.4 10.1 No No
6 empty 2.35 59.4 10 No No
7 empty 2.66 64 8.6 No No
8 empty 2.35 60.1 8.2 No No
9 empty 2.16 63.3 11.4 No No
10 empty 2.73 55.9 9 No No
2PJT_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 71.4 33.5 Yes No
2 empty 2.13 69.7 23.2 No No
3 empty 2.09 67.2 28.4 No No
4 empty 2.44 69.6 13.6 No No
5 empty 2.48 71.4 10.7 No No
6 empty 2.42 67.7 7.5 No No
7 empty 2.32 46.9 8.4 No No
8 empty 2.38 58.6 7 No No
9 empty 2.45 61.6 6.4 No No
10 empty 2.58 66.4 7.4 No No
2OZR_H Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 67.2 44.2 Yes Yes
2 empty 2.47 65 18.6 No No
3 empty 2.13 61.6 19.6 No No
4 empty 2.34 62.3 14.9 No No
5 empty 2.35 45 13.3 No No
6 empty 2.65 65.9 10 No No
7 empty 2.52 66.5 10 No No
8 empty 2.39 65.4 6.7 No No
9 empty 2.12 53.7 13.8 No No
10 empty 2.34 62.1 7.7 No No
2E2D_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 69.1 38.7 Yes Yes
2 empty 1.95 69 31.7 No No
3 empty 2.32 62.8 17.3 No No
4 empty 2.3 56.3 13.2 No No
5 empty 2.54 57.9 13.7 No No
6 empty 2.59 64.9 11.4 No No
7 empty 2.62 61.1 6.4 No No
8 empty 2.34 57.8 8.7 No No
9 empty 1.66 64 7.1 No No
10 empty 2.08 57.2 8.8 No No
4G0D_D Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 59.7 40.5 Yes No
2 bound 2.07 66.6 27.6 No No
3 empty 2.16 64.4 25.6 No No
4 empty 1.7 67.5 26.6 No No
5 empty 2.17 64.1 21.6 No No
6 bound 1.91 80.4 21 No No
7 empty 1.94 69 16 No No
8 bound 1.92 69 21 No No
9 empty 2.16 70 12.5 No No
10 empty 2.06 62.5 16 No No
5UWL_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 69.7 39.3 Yes Yes
2 empty 2.42 61.2 22.5 No No
3 empty 1.74 68.7 19.6 No No
4 empty 2.42 69.6 14.2 No No
5 empty 2.2 58.8 12.5 No No
6 empty 1.95 65.2 15.4 No No
7 empty 2.58 68.5 8.7 No No
8 empty 2.26 60.4 7.5 No No
9 empty 2.11 53.4 9 No No
10 empty 2.44 56.2 6.3 No No
1YOU_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 68.7 32.9 Yes No
2 empty 2.33 61.6 30.4 No No
3 empty 2.35 58.1 25.3 No No
4 empty 2.14 69.4 16.3 No No
5 empty 2.05 72.8 11.9 No No
6 empty 1.69 49 14.1 No No
7 empty 2.51 71 9.9 No No
8 empty 2.49 53.3 12.9 No No
9 empty 2.03 65.8 12.1 No No
10 empty 2.17 52.5 8.3 No No
3O2X_D Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 67.9 41.3 Yes Yes
2 empty 2.03 64.1 34.8 No No
3 empty 2.16 67.9 16.4 No No
4 bound 2.39 67.7 13.5 No No
5 empty 2.58 63.5 9.7 No No
6 empty 2.22 59.2 12.1 No No
7 empty 2.46 57.7 8.6 No No
8 empty 2.09 60.8 11 No No
9 empty 1.7 61.6 7.8 No No
10 empty 2.11 56.7 9.4 No No
830C_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 67.3 33.2 Yes Yes
2 empty 2.12 61.4 39.2 No No
3 empty 2.17 66.7 16 No No
4 empty 2.51 56.5 14.5 No No
5 empty 2.21 74.6 7.3 No No
6 empty 2.07 71.3 9.8 No No
7 empty 2.59 63.7 11.2 No No
8 empty 2.67 58.3 11.7 No No
9 empty 1.51 70.8 8.4 No No
10 empty 2.48 63.2 7.5 No No
5UWK_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 66 39.9 Yes No
2 empty 2.09 66.6 15.1 No No
3 empty 2.17 69.7 16 No No
4 empty 2.26 66.7 17.1 No No
5 empty 2.08 67 18 No No
6 empty 2.2 58.9 10.6 No No
7 empty 2.03 57.1 12.3 No No
8 empty 2.59 66.2 9.3 No No
9 empty 2.26 59.1 9 No No
10 empty 1.98 61.4 9.7 No No
3LJZ_B Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 69.7 39.6 Yes No
2 empty 1.97 65.2 35.8 No No
3 empty 2.15 70.8 24.6 No No
4 bound 2.49 65.9 17.3 No No
5 empty 2.26 64.1 10.8 No No
6 empty 2.42 69.5 9.8 No No
7 empty 2.28 56.1 10.1 No No
8 empty 2.45 59 11.4 No No
9 empty 2.13 58.5 8.9 No No
10 empty 2.22 62.6 6.4 No No
1ZTQ_C Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 69.2 36.6 Yes No
2 empty 2.03 66.3 26.9 No No
3 empty 2.59 66.4 16.4 No No
4 empty 2.5 66.1 10.1 No No
5 empty 2.01 69.8 8.4 No No
6 empty 2.16 62.2 8.3 No No
7 empty 2.02 58.4 9.4 No No
8 empty 2.55 63.5 7.2 No No
9 empty 2.11 63.1 5.5 No No
10 empty 2.82 71.1 6.3 No No
2PJT_C Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 69.5 38.5 Yes No
2 empty 2.27 64.3 23.7 No No
3 empty 2.15 67.7 28.7 No No
4 empty 2.1 71.5 15.2 No No
5 empty 2.55 70 12.3 No No
6 empty 2.43 64.7 10.2 No No
7 empty 2.34 61.4 8.8 No No
8 empty 1.85 49 6.8 No No
9 empty 2.34 68.2 6.9 No No
10 empty 1.96 67.5 5.6 No No
5B5P_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 70.9 37.1 Yes Yes
2 empty 2.07 60.3 39.9 No No
3 empty 2.53 61 25 No No
4 empty 2.35 67.1 13.8 No No
5 empty 1.97 51.7 10.6 No No
6 empty 2.5 66.8 8.8 No No
7 empty 2.21 62.8 9.4 No No
8 empty 2.37 50.3 10.2 No No
9 empty 1.86 51 6.9 No No
10 empty 2.09 60.1 10 No No
5BOT_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 66.8 44.3 Yes Yes
2 empty 2.19 70.7 27.6 No No
3 empty 2.3 64.1 17.4 No No
4 empty 2.08 71.5 12.1 No No
5 empty 2.06 65 12.9 No No
6 empty 1.89 68.6 10.6 No No
7 empty 2.38 56 15.3 No No
8 empty 2.71 61.3 11.7 No No
9 empty 2.27 63.1 12.4 No No
10 empty 2.03 60.4 11.1 No No
4JP4_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 66 40 Yes No
2 empty 1.9 59.6 32.3 No No
3 empty 2.29 61.7 21 No No
4 empty 2.4 67.5 15.3 No No
5 empty 2.67 66.5 9.5 No No
6 empty 1.95 61.1 9.8 No No
7 empty 2.42 52.8 8.2 No No
8 empty 2.41 65.4 6.1 No No
9 empty 2.46 52.9 6.4 No No
10 empty 2.63 59.8 5.7 No No
3WV1_B Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 65.1 45.6 Yes No
2 empty 1.95 66.5 15.3 No No
3 empty 1.89 71.4 14.3 No No
4 empty 2.45 64.1 16.1 No No
5 empty 2.12 66.1 14.2 No No
6 empty 2.25 60 11.6 No No
7 empty 2.48 65.6 9.3 No No
8 empty 2.05 52 12.4 No No
9 empty 2.17 64.1 6.4 No No
10 empty 2.2 67.6 5.7 No No
1XUD_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 66 40.2 Yes No
2 empty 2.1 59.7 28.1 No No
3 empty 1.92 67.1 19.3 No No
4 empty 2.4 66.7 13.9 No No
5 empty 2.54 69 8.4 No No
6 empty 2.43 50.3 9.2 No No
7 empty 2.22 63.4 8.2 No No
8 empty 2.24 64.8 7.7 No No
9 empty 2.07 62 6.4 No No
10 empty 2.79 47.3 7.4 No No
2D1N_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 66.6 40.5 Yes Yes
2 empty 2.36 69.9 26.6 No No
3 empty 2.5 60.3 13.3 No No
4 empty 1.97 69.2 7.7 No No
5 empty 2.57 65.5 5.5 No No
6 empty 2.19 63 8.4 No No
7 empty 2.17 69.3 4.6 No No
8 empty 2.76 64.2 6 No No
9 empty 2.35 45.2 6.1 No No
10 empty 2.63 60.5 4.4 No No
4A7B_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 67.2 46.3 Yes Yes
2 empty 2.24 68.9 21.2 No No
3 empty 2.28 64.9 17.3 No No
4 empty 2.7 64.3 11.6 No No
5 empty 2.52 56.8 14 No No
6 empty 2.11 65 7.4 No No
7 empty 1.91 45 10.3 No No
8 empty 1.93 56.8 8.9 No No
9 empty 2.23 61 6.5 No No
10 empty 1.67 51.9 6.1 No No
1FM1_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 74.2 29.6 Yes No
2 empty 1.94 61.6 22.8 No No
3 empty 2.39 63.2 18.7 No No
4 empty 2.16 59.1 15.2 No No
5 empty 2.13 65.6 20.6 No No
6 empty 1.98 68.8 11.9 No No
7 empty 1.85 64.4 13.3 No No
8 empty 2.24 64.7 13.3 No No
9 empty 2.49 56.4 7.8 No No
10 empty 1.87 48.1 8.6 No No
5UWN_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 66.7 41.3 Yes Yes
2 empty 2.16 70 24.4 No No
3 bound 2.45 64.1 14.7 No No
4 empty 2.38 53.6 13.4 No No
5 empty 2.54 68.1 9.2 No No
6 empty 2.2 56.3 9.7 No No
7 empty 2.07 55.2 10.5 No No
8 empty 2.1 53.1 13.7 No No
9 empty 2.23 59.6 14 No No
10 empty 2.4 67.3 9.1 No No
2OZR_E Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 66 44.2 Yes No
2 empty 1.98 69.3 24.2 No No
3 empty 2.07 60.3 18 No No
4 empty 2.2 60.9 15.5 No No
5 empty 2.39 64.2 14.7 No No
6 empty 2.61 65.1 10.1 No No
7 empty 2.74 52 15.6 No No
8 empty 2.52 62.5 10.7 No No
9 empty 2.21 60.6 9.3 No No
10 empty 2.19 56.7 9.8 No No
6HV2_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 70.6 39.4 Yes Yes
2 empty 2.1 66.1 27.4 No No
3 empty 2.55 61.6 23.9 No No
4 empty 1.94 64 14.1 No No
5 empty 2.36 64.9 10.2 No No
6 empty 2.38 63.9 9.9 No No
7 empty 2.54 61.6 8.9 No No
8 empty 2.07 62.7 9.9 No No
9 empty 2.42 63.1 6.4 No No
10 empty 2.7 69.8 7.8 No No
2OZR_B Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 70.4 40.6 Yes Yes
2 empty 2.13 63 39.8 No No
3 empty 2.26 70.3 13.7 No No
4 empty 2.61 49 14.8 No No
5 empty 2.37 57.1 10.5 No No
6 empty 2.61 65.5 8.4 No No
7 empty 2.17 59.5 13.2 No No
8 empty 2.22 52 11.7 No No
9 empty 2.01 63.2 6.4 No No
10 empty 2.23 60.8 7.9 No No
3WV2_A Collagenase 3 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 69.8 41.4 Yes Yes
2 empty 2.05 61.2 34.2 No No
3 empty 2.43 57.3 34.8 No No
4 empty 2.18 70.9 16.6 No No
5 empty 2.59 65.5 10 No No
6 empty 2.24 59.8 14 No No
7 empty 2.36 60.2 10.1 No No
8 empty 2.64 67.7 7 No No
9 empty 2.56 65.7 5.2 No No
10 empty 1.52 51.9 6.7 No No
4FVL_A Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 62.1 43.5 Yes No
2 bound 2.14 65.9 35.3 No No
3 bound 2.25 70.3 22.4 No No
4 empty 1.84 73.7 13.4 No No
5 bound 1.92 75.4 12.9 No No
6 empty 1.86 68.8 14 No No
7 empty 2.27 56.5 15.8 No No
8 bound 2.19 64.3 15 No No
9 empty 1.87 68.8 17.3 No No
10 empty 2.24 62.5 14.7 No No
2PJT_B Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 69.2 41.1 Yes No
2 empty 2.35 68.9 23.3 No No
3 empty 1.99 68.9 16.3 No No
4 empty 1.97 68.7 15.7 No No
5 empty 2.05 69.7 14.9 No No
6 empty 2.43 68.2 10.1 No No
7 empty 2.19 61.4 8.8 No No
8 empty 2.33 56 12.9 No No
9 empty 2.52 60 9.2 No No
10 empty 2.62 63.6 9.2 No No
5UWN_C Collagenase 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.65 59.2 35.4 Yes No
2 bound 1.87 71.3 20.3 No No
3 empty 1.94 63.7 17 No No
4 empty 2.06 65 13.6 No No
5 empty 2.03 65.9 20.7 No No
6 empty 1.89 66.4 15.9 No No
7 empty 2.11 60.4 14.4 No No
8 bound 2.28 61.5 19.5 No No
9 empty 2.2 68.7 12.9 No No
10 empty 2.33 56.2 12.7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed61
Domains assessed as druggable using the strict criteria45
Domains assessed as druggable using the relaxed criteria60

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1EUB_A (59503) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain Yes No
1FLS_A (59875) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain Yes No
1FM1_A (59876) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain Yes No
1PEX_A (27540) Collagenase 3 4-bladed beta-propeller, Hemopexin-like domain, Hemopexin-like domain 2.7Å No Yes
1XUC_A (122332) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 1.7Å Yes Yes
1XUC_B (122333) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 1.7Å Yes Yes
1XUD_B (122335) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 1.8Å Yes Yes
1XUD_A (122334) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 1.8Å Yes No
1XUR_B (122339) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 1.85Å Yes Yes
1XUR_A (122338) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 1.85Å Yes No
1XUR_B (4058857) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.85Å Yes Yes
1XUR_A (4058857) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.85Å Yes Yes
1XUR_B (4006298) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.85Å Yes Yes
1XUR_A (4006298) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.85Å Yes Yes
1YOU_B (4056506) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 2.06Å Yes Yes
1YOU_A (123783) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.06Å Yes No
1YOU_B (123784) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.06Å Yes No
1YOU_A (4056506) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 2.06Å Yes Yes
1ZTQ_A (125651) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2Å Yes Yes
1ZTQ_B (125652) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2Å Yes Yes
1ZTQ_C (125653) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2Å Yes No
1ZTQ_D (125654) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2Å Yes Yes
2D1N_B (131133) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.37Å Yes Yes
2D1N_A (131132) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.37Å Yes Yes
2E2D_A (131979) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2Å Yes Yes
2OW9_B (4049311) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.74Å Yes Yes
2OW9_A (4049311) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.74Å Yes Yes
2OW9_B (139420) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 1.74Å Yes Yes
2OW9_A (139419) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 1.74Å Yes Yes
2OZR_E (149123) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.1Å Yes No
2OZR_H (149126) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.1Å Yes Yes
2OZR_G (149125) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.1Å Yes Yes
2OZR_F (149124) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.1Å Yes Yes
2OZR_D (149122) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.1Å Yes Yes
2OZR_C (149121) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.1Å Yes Yes
2OZR_A (149119) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.1Å Yes Yes
2OZR_B (149120) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.1Å Yes Yes
2PJT_B (149576) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.7Å Yes No
2PJT_A (149575) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.7Å Yes No
2PJT_D (149578) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.7Å Yes No
2PJT_C (149577) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.7Å Yes No
2YIG_B (4063151) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.7Å Yes Yes
2YIG_A (4063151) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.7Å Yes Yes
2YIG_A (3600733) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 1.7Å Yes Yes
3ELM_A (4106548) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3ELM_B (4145482) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3ELM_A (4145482) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3ELM_B (4106548) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3I7G_A (4019345) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.95Å Yes Yes
3I7G_B (4019345) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.95Å Yes Yes
3I7G_A (4199482) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.95Å Yes Yes
3I7G_B (4199482) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.95Å Yes Yes
3I7I_B (4048001) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 2.208Å Yes Yes
3I7I_A (4048001) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 2.208Å Yes Yes
3I7I_A (4038803) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 2.208Å Yes Yes
3I7I_B (4038803) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 2.208Å Yes Yes
3KEC_A (3620619) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.04Å Yes Yes
3KEJ_A (3620626) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.2Å Yes Yes
3KEK_A (3620627) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 1.97Å Yes Yes
3KRY_B (4041130) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3KRY_D (4041130) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3KRY_A (4041130) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3KRY_C (4041130) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3LJZ_A (3630030) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2Å Yes Yes
3O2X_D (4030716) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3O2X_A (4260905) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3O2X_A (3640629) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 1.9Å Yes Yes
3O2X_B (4030716) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3O2X_C (4260905) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3O2X_D (4260905) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3O2X_B (4260905) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes Yes
3O2X_A (4112810) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes No
3O2X_C (4112810) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.9Å Yes No
3ZXH_B (4262877) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.3Å Yes Yes
3ZXH_A (4262877) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.3Å Yes Yes
3ZXH_B (4176131) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.3Å Yes Yes
3ZXH_A (4176131) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 1.3Å Yes Yes
456C_A (40402) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.4Å Yes No
456C_A (4171974) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 2.4Å Yes No
456C_B (40403) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 2.4Å Yes Yes
456C_B (4171974) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain (Homo Multimer) 2.4Å Yes No
830C_B (40401) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 1.6Å Yes Yes
830C_A (40400) Collagenase 3 Zincin-like, Metalloproteases ( zincins ) catalytic domain, Matrix metalloproteases catalytic domain 1.6Å Yes Yes
Ligand-based Druggability Score: 1.9
Ligand-based Druggability Score Percentile: 97%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


MMP13 is involved in 9 interactions in the network.


Druggability
Overall Druggability Percentile: 80.59
Druggability for Cancer Therapeutics: 59.14
Druggability for Other Therapeutics: 86.14
Cancer-Associated
Cancer-associated percentile : 46.71
Network Articulation Point
Is MMP13 critical for communication in the network?


Detailed Graph Legend:Help