Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MMP13 (P45452) - Overview - Molecular Target Synopsis

Protein


MMP13, Collagenase 3
Enzyme Classification 3.4.24.-
UniProt P45452

Also Known as MMP13_HUMAN, MMP13

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. Monomer. Interacts with TIMP1, TIMP2 and TIMP3. Binds (via the C-terminal region) to collagen.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
489ENSG00000137745ENST00000340273ENSP00000339672
471ENSG00000137745ENST00000260302ENSP00000260302P45452-1

Sub-cellular localization


UniProt: MMP13 is active in the following subcellular-locations: extracellular matrix, extracellular space, secreted.
GO terms: MMP13 is active in the following subcellular-locations: extracellular matrix, extracellular region, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MMP13 has gain in 13 cell-lines, loss in 6 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RXF_393, MCF7, SF_295

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Detroit 562, SCC-15, G118

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For MMP13 there are:
48 structures (121 chains) solved
42 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MMP13 has been screened with 3067 compounds (4033 bioactivities), 2123 compounds have bioactivities that show binding affinity of <= 500nM (2639 bioactivities). (see details)