Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ASPA (P45381) - Overview - Molecular Target Synopsis

Protein


ASPA, Aspartoacylase
Enzyme Classification 3.5.1.15
UniProt P45381

Also Known as ACY2_HUMAN, ASPA, ACY2, ASP

Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids. Homodimer.

4MXU
HUMAN BRAIN ASPARTOACYLASE MUTANT K213E COMPLEX WITH INTERMEDIATE ANALOG (N-PHOSPHONOMETHYL-L-ASPARTATE)
RCSB/PDB
Inspect Structure
See all 3D Structures for ASPA

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ASPA is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: ASPA is active in the following subcellular-locations: cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ASPA has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_N, MDA_MB_435, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, LN-18, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For ASPA there are:
8 structures (16 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis