Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MOB2 (P43563) - Overview - Molecular Target Synopsis

Protein


MOB2, CBK1 kinase activator protein MOB2
UniProt P43563

Also Known as MOB2_YEAST, MOB2

Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. Required for coordinating polarized cell growth during interphase with the onset of mitosis. Required for mother/daughter cell separation after cytokinesis. Also has a role in the prevention of nuclear export of ACE2 from the daughter cell nucleus after mitotic exit. It coordinates ACE2-dependent transcription with mitotic exit network activation. Interacts with protein kinase CBK1 to form the RAM CBK1-MOB2 kinase complex.

5NCL
CRYSTAL STRUCTURE OF THE CBK1-MOB2 KINASE-COACTIVATOR COMPLEX WITH AN SSD1 PEPTIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for MOB2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
287P43563-1

Sub-cellular localization


UniProt: MOB2 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: MOB2 is active in the following subcellular-locations: cellular bud, cellular bud neck, cellular bud tip, cytoplasm, mating projection tip, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MOB2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For MOB2 there are:
5 structures (6 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis