Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TNFRSF4 (P43489) - Overview - Molecular Target Synopsis

Protein


TNFRSF4, Tumor necrosis factor receptor superfamily member 4
UniProt P43489

Also Known as TNR4_HUMAN, TNFRSF4, TXGP1L

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity., (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B. Interacts with TRAF2, TRAF3 and TRAF5.

2HEY
CRYSTAL STRUCTURE OF MURINE OX40L BOUND TO HUMAN OX40
RCSB/PDB
Inspect Structure
See all 3D Structures for TNFRSF4

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
277ENSG00000186827ENST00000379236ENSP00000368538P43489-1

Sub-cellular localization


UniProt: TNFRSF4 is active in the following subcellular-locations: membrane.
GO terms: TNFRSF4 is active in the following subcellular-locations: cell surface, external side of plasma membrane, integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TNFRSF4 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: LOXIMVI, MALME_3M, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DU4475, RC-K8, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For TNFRSF4 there are:
3 structures (9 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis