Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ECE1 (P42892) - Overview - Molecular Target Synopsis

Protein


ECE1, Endothelin-converting enzyme 1
Enzyme Classification 3.4.24.71
UniProt P42892

Also Known as ECE1_HUMAN, ECE1

Converts big endothelin-1 to endothelin-1. Homodimer; disulfide-linked (PubMed:18992253). Interacts with PPP1R16B.

3DWB
STRUCTURE OF HUMAN ECE-1 COMPLEXED WITH PHOSPHORAMIDON
RCSB/PDB
Inspect Structure
See all 3D Structures for ECE1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project ECE1 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, TK_10, HOP_92

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G124, G120, BICR 31

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, NHLF, SK-N-SH

(see details)

3D Structures


For ECE1 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ECE1 has been screened with 524 compounds (693 bioactivities), 220 compounds have bioactivities that show binding affinity of <= 500nM (275 bioactivities). (see details)