Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRCP (P42785) - Overview - Molecular Target Synopsis

Protein


PRCP, Lysosomal Pro-X carboxypeptidase
Enzyme Classification 3.4.16.2
UniProt P42785

Also Known as PCP_HUMAN, PRCP, PCP

Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. Homodimer.

3N2Z
THE STRUCTURE OF HUMAN PROLYLCARBOXYPEPTIDASE AT 2.80 ANGSTROMS RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for PRCP

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PRCP is active in the following subcellular-locations: lysosome.
GO terms: PRCP is active in the following subcellular-locations: azurophil granule membrane, basal part of cell, extracellular exosome, ficolin-1-rich granule membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PRCP has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_ADR_RES, HL_60, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1500, MDA-MB-157, T-47D

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HUVEC, AG445

(see details)

RNA Interference


PRCP was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For PRCP there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PRCP has been screened with 436 compounds (520 bioactivities), 290 compounds have bioactivities that show binding affinity of <= 500nM (338 bioactivities). (see details)