FRK (P42685) - Overview - Molecular Target Synopsis
FRK, Tyrosine-protein kinase FRK
Enzyme Classification 220.127.116.11
Also Known as FRK_HUMAN, FRK, PTK5, RAK
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. Interacts (via the SH3-domain) with PTEN. Interacts with RB1.
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UniProt: FRK is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: FRK is active in the following subcellular-locations: azurophil granule lumen, cytosol, extracellular exosome, extracellular region, extrinsic component of cytoplasmic side of plasma membrane, intracellular, nucleus, specific granule lumen.