Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MATK (P42679) - Overview - Molecular Target Synopsis

Protein


MATK, Megakaryocyte-associated tyrosine-protein kinase
Enzyme Classification 2.7.10.2
UniProt P42679

Also Known as MATK_HUMAN, MATK, CTK, HYL

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. Interacts with KIT.

3US4
CRYSTAL STRUCTURE OF A SH2 DOMAIN OF A MEGAKARYOCYTE-ASSOCIATED TYROSINE KINASE (MATK) FROM HOMO SAPIENS AT 1.50 A RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for MATK

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MATK is active in the following subcellular-locations: cytoplasm, membrane.
GO terms: MATK is active in the following subcellular-locations: cytosol, extrinsic component of cytoplasmic side of plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MATK has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, MCF7, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UKE-1, HGC-27, KG-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, HeLa-S3, CD34-positive mobilized cell

(see details)

RNA Interference


MATK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MIAPACA2, C33A. (see details)

3D Structures


For MATK there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MATK has been screened with 127 compounds (141 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)