Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTR1B (P42025) - Overview - Molecular Target Synopsis

Protein


ACTR1B, Beta-centractin
UniProt P42025

Also Known as ACTY_HUMAN, ACTR1B, CTRN2

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
376ENSG00000115073ENST00000289228ENSP00000289228P42025-1

Sub-cellular localization


UniProt: ACTR1B is active in the following subcellular-locations: centrosome, cytoplasm, cytoskeleton, microtubule organizing center.
GO terms: ACTR1B is active in the following subcellular-locations: centrosome, cytoplasm, cytosol, dynactin complex, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, microtubule cytoskeleton, secretory granule lumen.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTR1B has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, MDA_MB_435, MDA_N

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, DMS 53, NCI-H1581

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HeLa-S3

(see details)

3D Structures


At greater than 90% identity similarity to ACTR1B there are:
7 structures (51 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTR1B has been screened with compounds ( bioactivities). (see details)