Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Mad (P42003) - Overview - Molecular Target Synopsis

Protein


Mad, Protein mothers against dpp
UniProt P42003

Also Known as MAD_DROME, Mad

Required for the function of decapentaplegic. May play an important role in mediating Dpp signaling. Involved in the BMP signaling pathway. Homotrimer (PubMed:19557331). Interacts with MAN1 (PubMed:20036230). Interacts with Sec13 and Nup93-1 (PubMed:20547758).

3GMJ
CRYSTAL STRUCTURE OF MAD MH2 DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for Mad

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
455P42003-1

Sub-cellular localization


UniProt: Mad is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: Mad is active in the following subcellular-locations: cytoplasm, nucleus, transcription factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Mad has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Mad there are:
2 structures (7 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Mad has been screened with compounds ( bioactivities). (see details)